Changes in Bone Mass After Discontinuation of Preexposure Prophylaxis With Tenofovir Disoproxil Fumarate/Emtricitabine in Young Men Who Have Sex With Men: Extension Phase Results of Adolescent Trials Network Protocols 110 and 113
Peter L Havens, Suzanne E Perumean-Chaney, Amit Patki, Stacey S Cofield, Craig M Wilson, Nancy Liu, Peter L Anderson, Raphael J Landovitz, Bill G Kapogiannis, Sybil G Hosek, Kathleen Mulligan, Peter L Havens, Suzanne E Perumean-Chaney, Amit Patki, Stacey S Cofield, Craig M Wilson, Nancy Liu, Peter L Anderson, Raphael J Landovitz, Bill G Kapogiannis, Sybil G Hosek, Kathleen Mulligan
Abstract
Human immunodeficiency virus-seronegative men aged 15-22 years who lost bone mineral density (BMD) during tenofovir disoproxil fumarate/emtricitabine preexposure prophylaxis (PrEP) showed BMD recovery 48 weeks following PrEP discontinuation. Lumbar spine and whole body BMD z-scores remained below baseline 48 weeks off PrEP in participants aged 15-19 years. Clinical Trials Registration. NCT01772823 (ATN 110) and NCT01769456 (ATN 113).
Keywords: adolescents; bone mineral density; men who have sex with men; preexposure prophylaxis; tenofovir disoproxil fumarate.
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Source: PubMed