Possible Mpox Protection from Smallpox Vaccine-Generated Antibodies among Older Adults
Iván Sanz-Muñoz, Laura Sánchez-dePrada, Javier Sánchez-Martínez, Silvia Rojo-Rello, Marta Domínguez-Gil, Cristina Hernán-García, Virginia Fernández-Espinilla, Raúl Ortiz de Lejarazu-Leonardo, Javier Castrodeza-Sanz, José María Eiros, Iván Sanz-Muñoz, Laura Sánchez-dePrada, Javier Sánchez-Martínez, Silvia Rojo-Rello, Marta Domínguez-Gil, Cristina Hernán-García, Virginia Fernández-Espinilla, Raúl Ortiz de Lejarazu-Leonardo, Javier Castrodeza-Sanz, José María Eiros
Abstract
Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71-80 years of age. Low antibody levels in 31.5% of this population indicates that addressing their vaccination should be a priority.
Keywords: Spain; antibodies; immunosenescence; monkeypox; mpox; sexually transmitted infections; smallpox; vaccine; vaccinia; viruses; zoonoses.
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References
- Centers for Disease Control and Prevention. Interim clinical considerations for use of JYNNEOS and ACAM2000 vaccines during the 2022. U.S. mpox outbreak [cited 2022 Jun 21].
- Centers for Disease Control and Prevention. Smallpox [cited 2022 Jul 20].
- World Health Organization. Multi-country monkeypox outbreak in non-endemic countries. 2022. [cited 2022 Jul 20].
- European Centre for Disease Prevention and Control. Monkeypox multi-country outbreak—first update [cited 2022 Jul 20].
- Carlos III Health Institute. Analysis of healthcare in Spain throughout the 20th century [in Spanish] [cited 2022 Jul 26].
- Comité Asesor de Vacunas de la Asociación Española de Pediatría. Vaccination against smallpox in Spain in the years prior to its eradication [in Spanish] [cited 2022 Jul 26].
- Rieckmann A, Villumsen M, Hønge BL, Sørup S, Rodrigues A, da Silva ZJ, et al. Phase-out of smallpox vaccination and the female/male HIV-1 prevalence ratio: an ecological study from Guinea-Bissau. BMJ Open. 2019;9:e031415. 10.1136/bmjopen-2019-031415
- Sørup S, Villumsen M, Ravn H, Benn CS, Sørensen TIA, Aaby P, et al. Smallpox vaccination and all-cause infectious disease hospitalization: a Danish register-based cohort study. Int J Epidemiol. 2011;40:955–63. 10.1093/ije/dyr063
- Belongia EA, Naleway AL. Smallpox vaccine: the good, the bad, and the ugly. Clin Med Res. 2003;1:87–92. 10.3121/cmr.1.2.87
- Centers for Disease Control and Prevention. History of smallpox [cited 2022 Jul 26].
- Ministerio de Sanidad. Carlos III Health Institute. Epidemiological situation of monkeypox cases in Spain [in Spanish] [cited 2022 Oct 31].
Source: PubMed