Possible Mpox Protection from Smallpox Vaccine-Generated Antibodies among Older Adults

Iván Sanz-Muñoz, Laura Sánchez-dePrada, Javier Sánchez-Martínez, Silvia Rojo-Rello, Marta Domínguez-Gil, Cristina Hernán-García, Virginia Fernández-Espinilla, Raúl Ortiz de Lejarazu-Leonardo, Javier Castrodeza-Sanz, José María Eiros, Iván Sanz-Muñoz, Laura Sánchez-dePrada, Javier Sánchez-Martínez, Silvia Rojo-Rello, Marta Domínguez-Gil, Cristina Hernán-García, Virginia Fernández-Espinilla, Raúl Ortiz de Lejarazu-Leonardo, Javier Castrodeza-Sanz, José María Eiros

Abstract

Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71-80 years of age. Low antibody levels in 31.5% of this population indicates that addressing their vaccination should be a priority.

Keywords: Spain; antibodies; immunosenescence; monkeypox; mpox; sexually transmitted infections; smallpox; vaccine; vaccinia; viruses; zoonoses.

Figures

Figure
Figure
Seroprevalence of smallpox vaccine–generated antibodies among older adults, Spain. Detectable vaccinia virus antibody levels in the different age groups analyzed and for the total study population are given.

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Source: PubMed

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