A Single-Arm Exploratory Study of NatureU Histra Disslove on Chronic Urticaria Symptoms (NUHISTRA)

Inclusion Criteria:

1. Participants who signed informed consent before the study and understood the study content, procedures, and possible adverse reactions.
2. Adults diagnosed with chronic urticaria by a dermatologist based on clinical symptoms and medical history.
3. Age 18 to 65 years.
4. Participants with typical wheals with itching and/or angioedema symptoms of chronic urticaria and either a Urticaria Activity Score 7 of at least 7 or a Urticaria Control Test score below 12.
5. Participants willing to maintain normal healthy routines during the study, avoid alcohol, and avoid foods likely to trigger allergic reactions.

Exclusion Criteria:

1. Severe internal organ disease, including heart disease, kidney disease, or other serious disease that could affect product metabolism.
2. Known allergy or intolerance to any ingredient of the study product.
3. Other skin disease or systemic disease that could affect urticaria manifestations.
4. Participation in another clinical trial or use of prohibited drug treatment.
5. Heavy smoking, alcohol abuse, or other lifestyle factors that could affect study results.
6. Severe psychological disorder or cognitive impairment that could affect compliance.
7. Inability to follow study dietary restrictions or requirements because of religious or personal reasons.
8. Abnormal blood routine, liver function, kidney function, or other laboratory test results outside the normal range.
9. Population for whom the product was contraindicated, including minors, participants planning pregnancy, pregnant or lactating participants, participants with liver or kidney disease history, and participants taking long-term medication.
10. Any other factor judged by the investigator to make participation inappropriate.