Health-related preferences of older patients with multimorbidity: an evidence map

Ana Isabel Gonzalez GONZALEZ, Christine Schmucker, Julia Nothacker, Edith Motschall, Truc Sophia Nguyen, Maria-Sophie Brueckle, Jeanet Blom, Marjan van den Akker, Kristian Röttger, Odette Wegwarth, Tammy Hoffmann, Sharon E Straus, Ferdinand M Gerlach, Joerg J Meerpohl, Christiane Muth, Ana Isabel Gonzalez GONZALEZ, Christine Schmucker, Julia Nothacker, Edith Motschall, Truc Sophia Nguyen, Maria-Sophie Brueckle, Jeanet Blom, Marjan van den Akker, Kristian Röttger, Odette Wegwarth, Tammy Hoffmann, Sharon E Straus, Ferdinand M Gerlach, Joerg J Meerpohl, Christiane Muth

Abstract

Objectives: To systematically identify knowledge clusters and research gaps in the health-related preferences of older patients with multimorbidity by mapping current evidence.

Design: Evidence map (systematic review variant).

Data sources: MEDLINE, EMBASE, PsycINFO, PSYNDEX, CINAHL and Science Citation Index/Social Science Citation Index/-Expanded from inception to April 2018.

Study selection: Studies reporting primary research on health-related preferences of older patients (mean age ≥60 years) with multimorbidity (≥2 chronic/acute conditions).

Data extraction: Two independent reviewers assessed studies for eligibility, extracted data and clustered the studies using MAXQDA-18 content analysis software.

Results: The 152 included studies (62% from North America, 28% from Europe) comprised 57 093 patients overall (range 9-9105). All used an observational design except for one interventional study: 63 (41%) were qualitative (59 cross-sectional, 4 longitudinal), 85 (57%) quantitative (63 cross-sectional, 22 longitudinal) and 3 (2%) used mixed methods. The setting was specialised care in 85 (56%) and primary care in 54 (36%) studies. We identified seven clusters of studies on preferences: end-of-life care (n=51, 34%), self-management (n=34, 22%), treatment (n=32, 21%), involvement in shared decision making (n=25, 17%), health outcome prioritisation/goal setting (n=19, 13%), healthcare service (n=12, 8%) and screening/diagnostic testing (n=1, 1%). Terminology (eg, preferences, views and perspectives) and concepts (eg, trade-offs, decision regret, goal setting) used to describe health-related preferences varied substantially between studies.

Conclusion: Our study provides the first evidence map on the preferences of older patients with multimorbidity. Included studies were mostly conducted in developed countries and covered a broad range of issues. Evidence on patient preferences concerning decision-making on screening and diagnostic testing was scarce. Differences in employed terminology, decision-making components and concepts, as well as the sparsity of intervention studies, are challenges for future research into evidence-based decision support seeking to elicit the preferences of older patients with multimorbidity and help them construct preferences.

Trial registration number: Open Science Framework (OSF): DOI 10.17605/OSF.IO/MCRWQ.

Keywords: general medicine (see internal medicine); geriatric medicine; internal medicine.

Conflict of interest statement

Competing interests: None declared.

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Figures

Figure 1
Figure 1
Evidence map Preferred Reporting Items for Systematic Reviews and Meta-Analyses flowchart.
Figure 2
Figure 2
Types of preference by setting and study design. Circle size represents the number of studies; pattern coding represents the study design. *The bubble plot displays more than the total number of included studies (n=174 vs n=152) because 22 studies were assigned to two different types of preference.

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