[Effectiveness of interventions based on telemedicine on health outcomes in patients with multimorbidity in Primary Care: A systematic review]

Beatriz Pascual-de la Pisa, Marta Palou-Lobato, Cristina Márquez Calzada, María José García-Lozano, Beatriz Pascual-de la Pisa, Marta Palou-Lobato, Cristina Márquez Calzada, María José García-Lozano

Abstract

Objective: To evaluate the effectiveness of telemedicine interventions to improve health outcomes in patients with multiple morbidities in Primary Health Care.

Design: A systematic review.

Data sources: INAHTA, Health Guidelines, NICE, Cochrane Library, Medline/PubMed and EMBASE up to April 2018.

Study selection: Inclusion criteria: patients (adults with 2 or more chronic diseases or a Charlson index greater than three); intervention (telemedicine intervention developed entirely in Primary Health Care); comparator (usual care); health outcomes (mortality, hospital admissions, emergency department visits, health-related quality of life, and satisfaction); study design(clinical practice guideline, systematic review, meta-analysis, randomised controlled clinical trial),and quasi-experimental design). English and Spanish language publication. A total of236 references were located.

Data extraction: Duplicated articles were removed. Titles, abstracts, and full text of references identified were assessed using the selection criteria; methodological quality assessment; data extraction, and qualitative analysis.

Results: Five articles, corresponding to 3 studies, were included, with 2 randomised controlled clinical trials and one quasi-experimental design. No significant results were observed in reducing mortality or improving health-related quality of life. The effectiveness of telemedicine on the number of hospital admissions or emergency visits showed contradictory results. Satisfaction was not measured in the studies included.

Conclusions: The relatively small number of studies, heterogeneity characteristics, and methodological limitations did not confirm the effectiveness of telemedicine intervention on the improvement of mortality, number of hospital admissions, emergency department visits, and health-related quality of life, compared to usual care.

Keywords: Atención primaria de salud; Hospital admission; Hospitalización; Mortalidad; Mortality; Multimorbilidad; Multiple morbidities; Outcome assessment; Primary Care; Resultados en salud; Telemedicina; Telemedicine.

Copyright © 2019 The Authors. Publicado por Elsevier España, S.L.U. All rights reserved.

Figures

https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8054282/bin/fx1.jpg
Esquema general del estudio. Diagrama de flujo PRISMA.. * NOTA: Los artículos podían ser excluidos por más de un motivo

References

    1. Instituto Nacional de Estadística. Proyecciones de población. 2018 [Internet] [citado 23 Jun 2019]. Disponible en:
    1. WHO. Multimorbidity: Technical series on safer primary Care. Geneva: World Health Organization; 2016.
    1. Poitras M.E., Maltais M.E., Bestard-Denommé L., Stewart M., Fortin M. What are the effective elements in patient-centered and multimorbidity care? A scoping review. BMC Health Serv Res. 2018;18:446. doi: 10.1186/s12913-018-3213-8.
    1. Massoudi B., Holvast F., Bockting C.L.H., Burger H., Blanker M.H. The effectiveness and cost-effectiveness of e-health interventions for depression and anxiety in primary care: A systematic review and meta-analysis. J Affect Disord. 2019;245:728–743. doi: 10.1016/j.jad.2018.11.050.
    1. Hanlon P., Daines L., Campbell C., McKinstry B., Weller D., Pinnock H. Telehealth interventions to support self-management of long-term conditions: A systematic metareview of diabetes, heart failure, asthma chronic obstructive pulmonary disease, and cancer. J Med Internet Res. 2017;19:e172. doi: 10.2196/jmir.6688.
    1. Martín-Lesende I., Orruño E., Mateos M., Recalde E., Asua J., Reviriego E. Telemonitoring in-home complex chronic patients from primary care in routine clinical practice: Impact on healthcare resources use. Eur J Gen Pract. 2017;23:135–142. doi: 10.1080/13814788.2017.1306516.
    1. Segrelles Calvo G., Gómez-Suárez C., Soriano J.B., Zamora E., Gónzalez-Gamarra A., González-Béjar M. A home telehealth program for patients with severe COPD: The PROMETE study. Respir Med. 2014;108:453–462. doi: 10.1016/j.rmed.2013.12.003.
    1. Yun J.E., Park J.E., Park H.Y., Lee H.Y., Park D.A. Comparative effectiveness of telemonitoring versus usual care for heart failure: A systematic review and meta-analysis. J Card Fail. 2018;24:19–28. doi: 10.1016/j.cardfail.2017.09.006.
    1. Hutton B., Catalá-López F., Moher D. The PRISMA statement extension for systematic reviews incorporating network meta-analysis: PRISMA-NMA. Med Clin (Barc). 2016;147:231–280. doi: 10.1016/j.medcli.2016.02.025.
    1. World Health Organization. The Challenges of a changing world. En: The World Health Report 2008 - Primary Health Care (Now More Than Ever). 2008. p. 21.
    1. Charlson M.E., Pompei P., Ales K.L., MacKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis. 1987;40:373–383.
    1. CASPe. Lectura Crítica - Caspe [Internet]. 2019 [citado 23 Jun 2019]. Disponible en:
    1. Jadad A.R., Moore R.A., Carroll D., Jenkinson C., Reynolds D.J., Gavaghan D.J. Assessing the quality of reports of randomised clinical trials: Is blinding necessary? Control Clin Trials. 1996;17:1–12.
    1. Takahashi P.Y., Pecina J.L., Upatising B., Chaudhry R., Shah N.D., Van Houten H. A randomized controlled trial of telemonitoring in older adults with multiple health issues to prevent hospitalizations and emergency department visits. Arch Intern Med. 2012;172:773–779. doi: 10.1001/archinternmed.2012.256.
    1. Pecina J.L., Hanson G.J., van Houten H., Takahashi P.Y. Impact of telemonitoring on older adults health-related quality of life: The Tele-ERA study. Qual Life Res. 2013;22:2315–2321. doi: 10.1007/s11136-013-0361-5.
    1. Upatising B., Hanson, Kim, Cha, Yih Y., Takahashi P. Effects of home telemonitoring on transitions between frailty states and death for older adults: A randomized controlled trial. Int J Gen Med. 2013;6:145–151. doi: 10.2147/IJGM.S40576.
    1. González-Ortega M., Gené-Badia J., Kostov B., García-Valdecasas V., Pérez-Martín C. Randomized trial to reduce emergency visits or hospital admissions using telephone coaching to complex patients. Fam Pract. 2017;34:219–226. doi: 10.1093/fampra/cmw119.
    1. Orozco-Beltrán D., Sánchez-Molla M., Sánchez J.J., Mira J.J. Telemedicine in primary care for patients with chronic conditions: The ValCrònic quasi-experimental study. J Med Internet Res. 2017;19:1–12. doi: 10.2196/jmir.7677.
    1. Gandek B., Ware J.E., Aaronson N.K., Apolone G., Bjorner J.B., Brazier J.E. Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: Results from the IQOLA Project International Quality of Life Assessment. J Clin Epidemiol. 1998;51:1171–1178.
    1. Dennis S.M., Harris M., Lloyd J., Powell Davies G., Faruqi N., Zwar N. Do people with existing chronic conditions benefit from telephone coaching? A rapid review. Aust Health Rev. 2013;37:381–388.
    1. Granja C., Janssen W., Johansen M.A. Factors determining the success and failure of ehealth interventions: Systematic review of the literature. J Med Internet Res. 2018;20:e10235. doi: 10.2196/10235.
    1. Flodgren G., Rachas A., Farmer A.J., Inzitari M., Shepperd S. Interactive telemedicine: Effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2015:CD002098.
    1. Melchiorre M.G., Lamura G., Barbabella F., ICARE4EU Consortium eHealth for people with multimorbidity: Results from the ICARE4EU project and insights from the “10 e's” by Gunther Eysenbach. PLoS One. 2018;14:e0207292. doi: 10.1371/journal.pone.0207292.
    1. Riaño D., Ortega W. Computer technologies to integrate medical treatments to manage multimorbidity. J Biomed Inform. 2017;75:1–13. doi: 10.1016/j.jbi.2017.09.009.
    1. Prados Castillejo J.A. Telemedicina, una herramienta también para el médico de familia. Aten Primaria. 2013;45:129–132. doi: 10.1016/j.aprim.2012.07.006.
    1. Bertoncello C., Colucci M., Baldovin T., Buja A., Baldo V. How does it work? Factors involved in telemedicine home-interventions effectiveness: A review of reviews. PLoS One. 2018;13:e0207332. doi: 10.1371/journal.pone.0207332.
    1. Mangin D., Parascandalo J., Khudoyarova O., Agarwal G., Bismah V., Orr S. Multimorbidity, eHealth and implications for equity: A cross-sectional survey of patient perspectives on eHealth. BMJ Open. 2019;9:e023731. doi: 10.1136/bmjopen-2018-023731.
    1. Abellán García A, Fernández-Mayoralas G, Pérez Díaz J, Puga González D, Rodríguez Laso A, Rodríguez Rodríguez V, et al. Informe sobre telemedicina y asistencia a pacientes crónicos. Consejo Superior de Investigaciones Científicas;2012 [citado 23 Jun 2019]. Disponible en:

Source: PubMed

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