Mortality Following Hip Fracture Surgery During COVID-19 Pandemic Compared to Pre-COVID-19 Period: A Case Matched Cohort Series

C De, P K Harbham, C Postoyalko, B Bhavanasi, V Paringe, K Theivendran, C De, P K Harbham, C Postoyalko, B Bhavanasi, V Paringe, K Theivendran

Abstract

Introduction: This study aims to report on clinical outcomes and 30-day mortality of patients with neck of femur fracture during COVID-19 pandemic and compare the outcomes in a cohort during the same period prior to the pandemic.

Material and methods: The study included 66 patients with hip fracture over the age of 60 years, presented between 1st March and 15th May 2020 and matched with the patients with hip fractures (75 patients) managed during the corresponding period in 2019 as control. Data was collected on demographics, comorbidities, COVID-19 status, procedures and mortality and complications.

Results: Thirty-day mortality following hip surgery was 13.6% during COVID-19 pandemic with all the mortalities in patients with ASA Grade 3 and 4. Mortality was considerably high for intracapsular fracture (20%) but highest in cemented hemiarthroplasty (20%). One third of the hip fractures operated in COVID-19 designated theatre died within 30 days of surgery. Thirty-day mortality rate for COVID-19 positive hip fracture patients were 55.5%. There has been higher 30-day mortality for hip surgeries during COVID-19 pandemic with positive correlation between patient's COVID-19 test status and 30-day mortality following hip surgeries.

Conclusion: There is strong association between 30-day mortality and the designated theatre (Clean/COVID) where the patients were operated on with higher mortality for intracapsular neck of femur fractures with significant mortality associated with cemented hemiarthroplasty particularly among symptomatic or COVID-19 positive patients. Therefore, adoption of a multidisciplinary approach is recommended to optimally balance the risk-benefit ratio for planning of management of hip fractures while considering patient's peri-operative outcomes.

Keywords: 30-day mortality; COVID-19; hip fracture; pandemic; pre-COVID-19.

© 2021 Malaysian Orthopaedic Association (MOA). All Rights Reserved.

Figures

Fig. 1:
Fig. 1:
Kaplan Meier Survival graph comparing Pre-COVID-19 Cohort (red) and COVID-19 Cohort (blue)

References

    1. World Health Organization (WHO): WHO announces COVID-19 outbreak a pandemic. 2020 (accessed on 19 April 2020)
    1. Horton R. Offline: COVID-19 and the NHS-“a national scandal”. Lancet. 2020;395(10229):1022. doi: 10.1016/S0140-6736.
    1. Besnier E, Tuech JJ, Schwarz L. We asked the experts: Covid-19 outbreak: is there still a place for scheduled surgery? “Reflection from pathophysiological data”. World J Surg. 2020;44(6):1695–8. oi: .
    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506.
    1. Coccolini F, Perrone G, Chiarugi M, Marzo FD, Ansaloni L, Scandroglio I et al. Surgery in COVID-19 patients: operational directives. World J Emerg Surg. 2020;15:25. doi: 10.1186/s13017-020-00307-2.
    1. COVIDSurg Collaborative. Global guidance for surgical care during the COVID-19 pandemic. Br J Surg. 2020;107(9):1097103. doi: 10.1002/bjs.11646.
    1. Tao KX, Zhang BX, Zhang P, Zhu P, Wang GB, Chen XP et al. Recommendations for general surgery clinical practice in novel coronavirus pneumonia situation. Zhonghua Wai Ke Za Zhi. 2020;58(0):E001. doi: 10.3760/cma.j.issn.0529-5815.2020.0001.
    1. Sandwell and West Birmingham Hospitals. 2019:114. Equality And Inclusion Report. United Kingdom: NHS Trust; p. (accessed on 17 May 2020)
    1. Office for National Statistics. Coronavirus (COVID-19). Latest data and analysis on coronavirus (COVID-19) in the UK and its effect on the economy and society. (accessed on 15 May 2020)
    1. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–62. doi: 10.1016/S0140-6736.
    1. Royal College of Physicians. London: RCP; 2019. National Hip Fracture Database annual report 2019. (accessed on 19 April 2020)
    1. Moppett IK, Parker M, Griffiths R, Bowers T, White SM, Moran CG. Nottingham Hip Fracture Score: longitudinal and multi-centre assessment. Br J Anaesth. 2012;109(4):546–50. doi: 10.1093/bja/aes187.
    1. Yeoh CJC, Fazal MA. ASA Grade and Elderly Patients with Femoral Neck Fracture. Geriatr Orthop Surg Rehabil. 2014;5(4):195–9. doi: 10.1177/2151458514560471.
    1. Wei J, Zeng L, Li S, Luo F, Xiang Z, Ding Q. Relationship between comorbidities and treatment decision-making in elderly hip fracture patients. Aging Clin Exp Res. 2019;31(12):1735–41. doi: 10.1007/s40520-019-01134-5.
    1. Faraj AA, Patil V. Correlation Between Pre-Injury Mobility and ASA Score With the Mortality Following Femoral Neck Fracture in Elderly. Eur J Orthop Surg Traumatol. 2006;16(2):130–134. doi: 10.1007/s00590-005-0026-3.
    1. Olsen F, Kotyra M, Houltz E, Ricksten SE. Bone Cement Implantation Syndrome in Cemented Hemiarthroplasty for Femoral Neck Fracture: Incidence, Risk Factors, and Effect on Outcome. Br J Anaesth. 2014;113(5):800–6. doi: 10.1093/bja/aeu226.
    1. COVIDSurg Collaborative. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. Lancet. 2020;396(10243):27–38. doi: 10.1016/S0140-6736.
    1. Lei S, Jiang F, Su W, Chen C, Chen J, Mei W et al. Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection. EClinicalMedicine. 2020;21:100331. doi: 10.1016/j.eclinm.2020.100331.
    1. Sheikh HQ, Hossain FS, Aqil A, Akinbamijo B, Mushtaq V, Kapoor H. A Comprehensive Analysis of the Causes and Predictors of 30-Day Mortality Following Hip Fracture Surgery. Clin Orthop Surg. 2017;9(1):10–8. doi: 10.4055/cios.2017.9.1.10.
    1. Moulton LS, Green NL, Sudahar T, Makwana NK, Whittaker JP. Outcome after conservatively managed intracapsular fractures of the femoral neck. Ann R Coll Surg Engl. 2015;97(4):279–82. doi: 10.1308/003588415X14181254788809.
    1. Archer JE, Kapor S, Piper D, Odeh A. The impact of COVID-19 on 30-day mortality in patients with neck of femur fractures. Bone Jt Open. 2020;1(7):326–9. doi: 10.1302/2046-3758.17.BJO-2020-0066.R1.

Source: PubMed

3
Abonnieren