Effect of oral sodium bicarbonate on fibroblast growth factor-23 in patients with chronic kidney disease: a pilot study

Wei Chen, Michal L Melamed, Thomas H Hostetter, Carolyn Bauer, Amanda C Raff, Anthony L Almudevar, Amy Lalonde, Susan Messing, Matthew K Abramowitz, Wei Chen, Michal L Melamed, Thomas H Hostetter, Carolyn Bauer, Amanda C Raff, Anthony L Almudevar, Amy Lalonde, Susan Messing, Matthew K Abramowitz

Abstract

Background: The regulation of fibroblast growth factor-23 (FGF23) secretion in patients with chronic kidney disease (CKD) is incompletely understood. An in vitro study showed that metabolic acidosis increased FGF23 in mouse bone. The objective of this study is to evaluate the effect of oral sodium bicarbonate on circulating FGF23 levels in patients with CKD.

Methods: This was a single-blind pilot study. Twenty adults with estimated glomerular filtration rate between 15-45 mL/min/1.73 m(2) and serum bicarbonate between 20-24 mEq/L were treated with placebo for 2 weeks, followed by increasing doses of oral sodium bicarbonate (0.3, 0.6 and 1.0 mEq/kg/day) in 2 week intervals for a total of 6 weeks. C-terminal FGF23 levels were measured at the initial visit, after 2 weeks of placebo and after 6 weeks of bicarbonate therapy. Wilcoxon matched-pairs signed-rank test was used to compare FGF23 before and after sodium bicarbonate.

Results: After 6 weeks of oral sodium bicarbonate, the median FGF23 increased significantly from 150.9 RU/mL (IQR 107.7-267.43) to 191.4 RU/mL (IQR 132.6-316.9) (p = 0.048) and this persisted after excluding participants who received activated vitamin D.

Conclusions: FGF23 increased after short-term oral sodium bicarbonate therapy in patients with CKD and mild metabolic acidosis. It is unclear whether this was due to the alkalinizing effect of sodium bicarbonate or other factors.

Trial registration: The study was registered at ClinicalTrials.gov ( NCT00888290 ) on April 23, 2009.

Keywords: Alkali therapy; Fibroblast growth factor-23; Metabolic acidosis; Mineral metabolism; Sodium bicarbonate; Vitamin D.

Figures

Fig. 1
Fig. 1
Enrollment. Twenty participants were included in the final analysis. Two completed only 6 weeks of the study and received 2 weeks of placebo and 4 weeks of sodium bicarbonate
Fig. 2
Fig. 2
FGF23 before and after sodium bicarbonate therapy (n = 20). FGF23 before sodium bicarbonate therapy was calculated by averaging FGF23 at the initial visit and after 2-week placebo. Participant #16 was the outlier

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