Multiphasic Prehabilitation Across the Cancer Continuum: A Narrative Review and Conceptual Framework

Daniel Santa Mina, Stefanus J van Rooijen, Enrico M Minnella, Shabbir M H Alibhai, Priya Brahmbhatt, Susanne O Dalton, Chelsia Gillis, Michael P W Grocott, Doris Howell, Ian M Randall, Catherine M Sabiston, Julie K Silver, Gerrit Slooter, Malcolm West, Sandy Jack, Franco Carli, Daniel Santa Mina, Stefanus J van Rooijen, Enrico M Minnella, Shabbir M H Alibhai, Priya Brahmbhatt, Susanne O Dalton, Chelsia Gillis, Michael P W Grocott, Doris Howell, Ian M Randall, Catherine M Sabiston, Julie K Silver, Gerrit Slooter, Malcolm West, Sandy Jack, Franco Carli

Abstract

The field of cancer survivorship has significantly advanced person-centered care throughout the cancer continuum. Within cancer survivorship, the last decade has seen remarkable growth in the investigation of prehabilitation comprising pre-treatment interventions to prevent or attenuate the burden of oncologic therapies. While the majority of evidence remains in the surgical setting, prehabilitation is being adapted to target modifiable risk factors that predict poor treatment outcomes in patients receiving other systemic and localized anti-tumor treatments. Here, we propose a multiphasic approach for prehabilitation across the cancer continuum, as a conceptual framework, to encompass the variability in cancer treatment experiences while adopting the most inclusive definition of the cancer survivor.

Keywords: cancer; conceptual framework; continuum of care; enhanced recovery after surgery; oncology; prehabilitation; rehabilitation; survivorship.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Santa Mina, van Rooijen, Minnella, Alibhai, Brahmbhatt, Dalton, Gillis, Grocott, Howell, Randall, Sabiston, Silver, Slooter, West, Jack and Carli.

Figures

Figure 1
Figure 1
Example of coordinated rehabilitation and prehabilitation between two treatments.
Figure 2
Figure 2
Prehabilitation within the Cancer Continuum (Including Recurrence or New Primary Cancers).
Figure 3
Figure 3
Prehabilitation Across the Cancer Continuum.

References

    1. Hewitt M, Greenfield S, Stovall E. eds. From Cancer Patient to Cancer Survivor - Lost in Transition. Washington, D.C: National Academies Press; (2006). 10.17226/11613
    1. Nekhlyudov L, Ganz PA, Arora NK, Rowland JH. Going Beyond Being Lost in Transition: A Decade of Progress in Cancer Survivorship. J Clin Oncol (2017) 35(18):1978–81. 10.1200/JCO.2016.72.1373
    1. Cromes G, Fred J. Implementation of Interdisciplinary Cancer Rehabilitation. Rehabil Couns Bull (1978) 21:230–7.
    1. Stout NL, Binkley JM, Schmitz KH, Andrews K, Hayes SC, Campbell KL, et al. A prospective surveillance model for rehabilitation for women with breast cancer. Cancer (2012) 118(S8):2191–200. 10.1002/cncr.27476
    1. Alfano CM, Cheville AL, Mustian K. Developing High-Quality Cancer Rehabilitation Programs: A Timely Need. Am Soc Clin Oncol Educ B (2016) 35(36):241–9. 10.1200/EDBK_156164
    1. Silver JK, Baima J. Cancer Prehabilitation. Am J Phys Med Rehabil (2013) 92(8):715–27. 10.1097/PHM.0b013e31829b4afe
    1. Dronkers JJ, Chorus AMJ, van Meeteren NLU, Hopman-Rock M. The association of pre-operative physical fitness and physical activity with outcome after scheduled major abdominal surgery. Anaesthesia (2013) 68(1):67–73. 10.1111/anae.12066
    1. Heldens AFJM, Bongers BC, Lenssen AF, Stassen LPS, Buhre WF, van Meeteren NLU. The association between performance parameters of physical fitness and postoperative outcomes in patients undergoing colorectal surgery: An evaluation of care data. Eur J Surg Oncol (2017) 43(11):2084–92. 10.1016/j.ejso.2017.08.012
    1. Treanor C, Kyaw T, Donnelly M. An international review and meta-analysis of prehabilitation compared to usual care for cancer patients. J Cancer Surviv (2018) 12(1):64–73. 10.1007/s11764-017-0645-9
    1. Piraux E, Caty G, Reychler G. Effects of preoperative combined aerobic and resistance exercise training in cancer patients undergoing tumour resection surgery: A systematic review of randomised trials. Surg Oncol (2018) 27(3):584–94. 10.1016/j.suronc.2018.07.007
    1. Tsimopoulou I, Pasquali S, Howard R, Desai A, Gourevitch D, Tolosa I, et al. Psychological Prehabilitation Before Cancer Surgery: A Systematic Review. Ann Surg Oncol (2015) 22(13):4117–23. 10.1245/s10434-015-4550-z
    1. Gillis C, Buhler K, Bresee L, Carli F, Gramlich L, Culos-Reed N, et al. Effects of Nutritional Prehabilitation, With and Without Exercise, on Outcomes of Patients Who Undergo Colorectal Surgery: A Systematic Review and Meta-analysis. Gastroenterology (2018) 155(2):391–410.e4. 10.1053/j.gastro.2018.05.012
    1. Gillis C, Fenton TR, Sajobi TT, Minnella EM, Awasthi R, Loiselle SÈ, et al. Trimodal prehabilitation for colorectal surgery attenuates post-surgical losses in lean body mass: A pooled analysis of randomized controlled trials. Clin Nutr (2019) 38(3):1053–60. 10.1016/j.clnu.2018.06.982
    1. Minnella EM, Carli F. Prehabilitation and functional recovery for colorectal cancer patients. Eur J Surg Oncol (2018) 44(7):919–26. 10.1016/J.EJSO.2018.04.016
    1. Tew GA, Ayyash R, Durrand J, Danjoux GR. Clinical guideline and recommendations on pre-operative exercise training in patients awaiting major non-cardiac surgery. Anaesthesia (2018) 73(6):750–68. 10.1111/anae.14177
    1. Twombly R. What’s in a Name: Who Is a Cancer Survivor? J Natl Cancer Inst (2004) 96(19):1414–5. 10.1093/jnci/96.19.1414
    1. Clark MM, Atherton PJ, Lapid MI, Rausch SM, Frost MH, Cheville AL, et al. Caregivers of patients with cancer fatigue: a high level of symptom burden. Am J Hosp Palliat Care (2014) 31(2):121–5. 10.1177/1049909113479153
    1. Mitchell AJ, Ferguson DW, Gill J, Paul J, Symonds P. Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: A systematic review and meta-analysis. Lancet Oncol (2013) 14(8):721–32. 10.1016/S1470-2045(13)70244-4
    1. Bevans M, Sternberg EM. Caregiving Burden, Stress, and Health Effects Among Family Caregivers of Adult Cancer Patients. JAMA (2012) 307(4):398–403. 10.1001/jama.2012.29
    1. Hebert RS, Schulz R, Copeland VC, Arnold RM. Preparing Family Caregivers for Death and Bereavement. Insights from Caregivers of Terminally Ill Patients. J Pain Symptom Manage (2009) 37(1):3–12. 10.1016/J.JPAINSYMMAN.2007.12.010
    1. Loke AY, Li Q, Man LS. Preparing Family Members for the Death of Their Loved One With Cancer. J Hosp Palliat Nurs (2013) 15(2):E1–11. 10.1097/NJH.0b013e3182860650
    1. Lambert S, Girgis A. Unmet supportive care needs among informal caregivers of patients with cancer: Opportunities and challenges in informing the development of interventions. Asia Pac J Oncol Nurs (2017) 4(2):136. 10.4103/2347-5625.204485
    1. Dionne-Odom JN, Demark-Wahnefried W, Taylor RA, Rocque GB, Azuero A, Acemgil A, et al. The self-care practices of family caregivers of persons with poor prognosis cancer: differences by varying levels of caregiver well-being and preparedness. Support Care Cancer (2017) 25(8):2437–44. 10.1007/s00520-017-3650-7
    1. Applebaum AJ, Breitbart W. Care for the cancer caregiver: A systematic review. Palliat Support Care (2013) 11:231–52. NIH Public Access. 10.1017/S1478951512000594
    1. Fu F, Zhao H, Tong F, Chi I. A Systematic Review of Psychosocial Interventions to Cancer Caregivers. Front Psychol (2017) 8(MAY):834. 10.3389/fpsyg.2017.00834
    1. Carli F, Zavorsky GS. Optimizing functional exercise capacity in the elderly surgical population. Curr Opin Clin Nutr Metab Care (2005) 8(1):23–32. 10.1097/00075197-200501000-00005
    1. Minnella EM, Bousquet-Dion G, Awasthi R, Scheede-Bergdahl C, Carli F. Multimodal prehabilitation improves functional capacity before and after colorectal surgery for cancer: a five-year research experience. Acta Oncol (Madr) (2017) 56(2):295–300. 10.1080/0284186X.2016.1268268
    1. Santa Mina D, Brahmbhatt P, Lopez C, Baima J, Gillis C, Trachtenberg L, et al. The Case for Prehabilitation Prior to Breast Cancer Treatment. Phys Med Rehabil (2017) 9(9):S305–16. 10.1016/j.pmrj.2017.08.402
    1. Carli F, Silver JK, Feldman LS, McKee A, Gilman S, Gillis C, et al. Surgical Prehabilitation in Patients with Cancer. Phys Med Rehabil Clin N Am (2017) 28(1):49–64. 10.1016/j.pmr.2016.09.002
    1. Halliday L, Wynter-Blyth V, Osborn H, King A, Moorthy K. Adherence to prehabilitation in oesophago-gastric cancer patients. Clin Nutr ESPEN (2017) 19:90. 10.1016/j.clnesp.2017.04.056
    1. Brahmbhatt P, Sabiston CM, Lopez C, Chang E, Goodman J, Jones J, et al. Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed Methods Study. Front Oncol (2020) 10:1–13. Under Rev. 10.3389/fonc.2020.571091
    1. Ferreira V, Agnihotram RV, Bergdahl A, van Rooijen SJ, Awasthi R, Carli F, et al. Maximizing patient adherence to prehabilitation: what do the patients say? Support Care Cancer (2018) 26(8):2717–23. 10.1007/s00520-018-4109-1
    1. Framework for Action on Interprofessional Education and Collaborative Practice. Geneva: (2010).
    1. Barberan-Garcia A, Ubré M, Roca J, Lacy AM, Burgos F, Risco R, et al. Personalised Prehabilitation in High-risk Patients Undergoing Elective Major Abdominal Surgery. Ann Surg (2018) 267(1):50–6. 10.1097/SLA.0000000000002293
    1. Barberan-Garcia A, Ubre M, Pascual-Argente N, Risco R, Faner J, Balust J, et al. Post-discharge impact and cost-consequence analysis of prehabilitation in high-risk patients undergoing major abdominal surgery: secondary results from a randomised controlled trial. Br J Anaesth (2019) 123:1–7. 10.1016/j.bja.2019.05.032
    1. Moran J, Guinan E, McCormick P, Larkin J, Mockler D, Hussey J, et al. The ability of prehabilitation to influence postoperative outcome after intra-abdominal operation: A systematic review and meta-analysis. Surgery (2016) 160(5):1189–201. 10.1016/j.surg.2016.05.014
    1. Gillis C, Carli F. Promoting perioperative metabolic and nutritional care. Anesthesiology (2015) 123:1455–72. 10.1097/ALN.0000000000000795
    1. Gillis C, Wischmeyer PE. Pre-operative nutrition and the elective surgical patient: why, how and what?. Anaesthesia (2019) 74(Suppl 1):27–35. 10.1111/anae.14506
    1. Snowden CP, Prentis J, Jacques B, Anderson H, Manas D, Jones D, et al. Cardiorespiratory fitness predicts mortality and hospital length of stay after major elective surgery in older people. Ann Surg (2013) 257(6):999–1004. 10.1097/sla.0b013e31828dbac2
    1. Smith TB, Stonell C, Purkayastha S, Paraskevas P. Cardiopulmonary exercise testing as a risk assessment method in non cardio-pulmonary surgery: A systematic review. Anaesthesia (2009) 64:883–93. 10.1111/j.1365-2044.2009.05983.x
    1. Carmichael JC, Keller DS, Baldini G, Bordeianou L, Weiss E, Lee L, et al. Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons. Dis Colon Rectum (2017) 60(8):761–84. 10.1097/DCR.0000000000000883
    1. Berkel AEM, Bongers BC, van Kamp M-JS, Kotte H, Weltevreden P, de Jongh FHC, et al. The effects of prehabilitation versus usual care to reduce postoperative complications in high-risk patients with colorectal cancer or dysplasia scheduled for elective colorectal resection: study protocol of a randomized controlled trial. BMC Gastroenterol (2018) 18(1):29. 10.1186/s12876-018-0754-6
    1. McIsaac DI, Saunders C, Hladkowicz E, Bryson GL, Forster AJ, Gagne S, et al. PREHAB study: a protocol for a prospective randomised clinical trial of exercise therapy for people living with frailty having cancer surgery. BMJ Open (2018) 8(6):e022057. 10.1136/bmjopen-2018-022057
    1. van Rooijen S, Carli F, Dalton S, Thomas G, Bojesen R, Le Guen M, et al. Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation. BMC Cancer (2019) 19(1):98. 10.1186/s12885-018-5232-6
    1. Wood WA, Deal AM, Reeve BB, Abernethy AP, Basch E, Mitchell SA, et al. Cardiopulmonary fitness in patients undergoing hematopoietic SCT: a pilot study. Bone Marrow Transplant (2013) 48(10):1342–9. 10.1038/bmt.2013.58
    1. van Haren IEPM, Staal JB, Potting CM, Atsma F, Hoogeboom TJ, Blijlevens NMA, et al. Physical exercise prior to hematopoietic stem cell transplantation: A feasibility study. Physiother Theory Pract (2018) 34(10):747–56. 10.1080/09593985.2018.1423655
    1. Takekiyo T, Dozono K, Mitsuishi T, Murayama Y, Maeda A, Nakano N, et al. Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation. Support Care Cancer (2015) 23(4):985–92. 10.1007/s00520-014-2425-7
    1. Keen C, Skilbeck J, Ross H, Smith L, Collins K, Dixey J, et al. Is it feasible to conduct a randomised controlled trial of pretransplant exercise (prehabilitation) for patients with multiple myeloma awaiting autologous haematopoietic stem cell transplantation? Protocol for the PREeMPT study. BMJ Open (2018) 8(3):e021333. 10.1136/bmjopen-2017-021333
    1. Wiskemann J, Dreger P, Schwerdtfeger R, Bondong A, Huber G, Kleindienst N, et al. Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation. Blood (2011) 117(9):2604–13. 10.1182/blood-2010-09-306308
    1. van Haren IEPM, Timmerman H, Potting CM, Blijlevens NMA, Staal JB, Nijhuis-van der Sanden MWG. Physical Exercise for Patients Undergoing Hematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analyses of Randomized Controlled Trials. Phys Ther (2013) 93(4):514–28. 10.2522/ptj.20120181
    1. Santa Mina D, Dolan LB, Lipton JH, Au D, Camacho Pérez E, Franzese A, et al. Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial. J Clin Med (2020) 9(6):1854. 10.3390/jcm9061854
    1. West MA, Loughney L, Lythgoe D, Barben CCPC, Adams VVL, Bimson WWE, et al. The Effect of Neoadjuvant Chemoradiotherapy on Whole-Body Physical Fitness and Skeletal Muscle Mitochondrial Oxidative Phosphorylation In Vivo in Locally Advanced Rectal Cancer Patients – An Observational Pilot Study. Galgani J, editor. PloS One (2014) 9(12):1–15. 10.1371/journal.pone.0111526
    1. West MA, Loughney L, Barben CP, Sripadam R, Kemp GJ, Grocott MPW, et al. The effects of neoadjuvant chemoradiotherapy on physical fitness and morbidity in rectal cancer surgery patients. Eur J Surg Oncol (2014) 40(11):1421–8. 10.1016/j.ejso.2014.03.021
    1. Jack S, West MAA, Raw D, Marwood S, Ambler G, Cope TMM, et al. The effect of neoadjuvant chemotherapy on physical fitness and survival in patients undergoing oesophagogastric cancer surgery. Eur J Surg Oncol (2014) 40(10):1313–20. 10.1016/j.ejso.2014.03.010
    1. Navidi M, Phillips AW, Griffin SM, Duffield KE, Greystoke A, Sumpter K, et al. Cardiopulmonary fitness before and after neoadjuvant chemotherapy in patients with oesophagogastric cancer. Br J Surg (2018) 105(7):900–6. 10.1002/bjs.10802
    1. West MA, Loughney L, Lythgoe D, Barben CP, Sripadam R, Kemp GJ, et al. Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. Br J Anaesth (2015) 114(2):244–51. 10.1093/bja/aeu318
    1. Tashiro M, Yamada S, Sonohara F, Takami H, Suenaga M, Hayashi M, et al. Clinical Impact of Neoadjuvant Therapy on Nutritional Status in Pancreatic Cancer. Ann Surg Oncol (2018) 25(11):3365–71. 10.1245/s10434-018-6699-8
    1. Thau MR, Lange KC, Ahmed KA, Hoffe SE, Almhanna K, Shridhar R. Significant Weight Loss in the Neoadjuvant Setting Is Predictive of Whether Patients Undergo Surgery Following Chemoradiation for Locally Advanced Esophageal Cancer. Int J Radiat Oncol (2014) 90(1):S349. 10.1016/j.ijrobp.2014.05.1139
    1. Loughney L, West MA, Kemp GJ, Grocott MPW, Jack S. Exercise intervention in people with cancer undergoing neoadjuvant cancer treatment and surgery: A systematic review. Eur J Surg Oncol (2016) 42(1):28–38. 10.1016/j.ejso.2015.09.027
    1. West MA, Loughney L, Lythgoe D, Barben CP, Sripadam R, Kemp GJ, et al. Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. Br J Anaesth (2015) 114(2):244–51. 10.1093/bja/aeu318
    1. Bott R, Zylstra J, Whyte G, Davies A. Exercise Prehabilitation during Neoadjuvant Cancer Treatment in Patients with Gastrointestinal and Thoracic Cancer: A Systematic Review. Gastrointest Cancer Res Ther (2017) 2(1):1014. 10.26420/gastrointestcancerrestherl.2017.1014
    1. Rao R, Cruz V, Peng Y, Harker-Murray A, Haley BB, Zhao H, et al. Bootcamp during Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial. Breast Cancer Basic Clin Res (2012) 6:39–46. 10.4137/BCBCR.S9221
    1. Heldens AFJM, Bongers BC, de Vos-Geelen J, van Meeteren NLU, Lenssen AF. Feasibility and preliminary effectiveness of a physical exercise training program during neoadjuvant chemoradiotherapy in individual patients with rectal cancer prior to major elective surgery. Eur J Surg Oncol (2016) 42(9):1322–30. 10.1016/J.EJSO.2016.03.021
    1. Christensen JF, Simonsen C, Banck-Petersen A, Thorsen-Streit S, Herrstedt A, Djurhuus SS, et al. Safety and feasibility of preoperative exercise training during neoadjuvant treatment before surgery for adenocarcinoma of the gastro-oesophageal junction. BJS Open (2018) 3(1):74–84. 10.1002/bjs5.50110
    1. Hornsby WE, Douglas PS, West MJ, Kenjale AA, Lane AR, Schwitzer ER, et al. Safety and efficacy of aerobic training in operable breast cancer patients receiving neoadjuvant chemotherapy: A phase II randomized trial. Acta Oncol (Madr) (2014) 53(1):65–74. 10.3109/0284186X.2013.781673
    1. Singh F, Galvão DA, Newton RU, Spry NA, Baker MK, Taaffe DR. Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients. Integr Cancer Ther (2018) 17(3):952–9. 10.1177/1534735418781736
    1. Chan A, Woods R, Kennecke H, Gill S. Factors associated with delayed time to adjuvant chemotherapy in stage iii colon cancer. Curr Oncol (2014) 21(4):181–6. 10.3747/co.21.1963
    1. Tabchi S, Kassouf E, Florescu M, Tehfe M, Blais N. Factors influencing treatment selection and survival in advanced lung cancer. Curr Oncol (2017) 24(2):e115–22. 10.3747/co.24.3355
    1. Kim HW, Lee J-C, Lee J, Kim JW, Kim J, Hwang J-H. Early versus delayed initiation of adjuvant treatment for pancreatic cancer. PloS One (2017) 12(3):e0173960. 10.1371/journal.pone.0173960
    1. Pai VB, Nahata MC. Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf (2000) 22(4):263–302. 10.2165/00002018-200022040-00002
    1. Hydock DS, Lien CY, Schneider CM, Hayward R. Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction. Med Sci Sports Exerc (2008) 40(5):808–17. 10.1249/MSS.0b013e318163744a
    1. Wonders KY, Hydock DS, Schneider CM, Hayward R. Acute exercise protects against doxorubicin cardiotoxicity. Integr Cancer Ther (2008) 7(3):147–54. 10.1177/1534735408322848
    1. Chicco AJ, Schneider CM, Hayward R. Exercise Training Attenuates Acute Doxorubicin-Induced Cardiac Dysfunction. J Cardiovasc Pharmacol (2006) 47(2):182–9. 10.1097/01.fjc.0000199682.43448.2d
    1. Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci (2008) 105(24):8215–20. 10.1073/pnas.0708100105
    1. Kawaguchi T, Takemura G, Kanamori H, Takeyama T, Watanabe T, Morishita K, et al. Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes. Cardiovasc Res (2012) 96(3):456–65. 10.1093/cvr/cvs282
    1. Kirkham AA, Shave RE, Bland KA, Bovard JM, Eves ND, Gelmon KA, et al. Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT. Int J Cardiol (2017) 245:263–70. 10.1016/j.ijcard.2017.07.037
    1. Martin L, Birdsell L, MacDonald N, Reiman T, Clandinin MT, McCargar LJ, et al. Cancer cachexia in the age of obesity: Skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol (2013) 31(12):1539–47. 10.1200/JCO.2012.45.2722
    1. Prado CMM, Baracos VE, McCargar LJ, Reiman T, Mourtzakis M, Tonkin K, et al. Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clin Cancer Res (2009) 15(8):2920–6. 10.1158/1078-0432.CCR-08-2242
    1. Jimenez-Fonseca P, Calderón C, Hernández R, Ramón y Cajal T, Mut M, Ramchandani A, et al. Factors associated with anxiety and depression in cancer patients prior to initiating adjuvant therapy. Clin Transl Oncol (2018) 20(11):1408–15. 10.1007/s12094-018-1873-9
    1. Institute of Medicine (US) Committee on Psychosocial Services to Cancer Patients/Families in a Community Setting The Psychosocial Needs of Cancer Patients. In: Adler NE, Page AEK, editors. Cancer Care for the Whole Patient: Meeting Psychosocial Health Needs. Washington, DC: National Academies Press (US; (2008). p. 1. E, (DC) W.
    1. Delgado-Guay M, Ferrer J, Rieber AG, Rhondali W, Tayjasanant S, Ochoa J, et al. Financial Distress and Its Associations With Physical and Emotional Symptoms and Quality of Life Among Advanced Cancer Patients. Oncologist (2015) 20(9):1092–8. 10.1634/theoncologist.2015-0026
    1. Zahid JA, Grummedal O, Madsen MT, Gögenur I. Prevention of depression in patients with cancer: A systematic review and meta-analysis of randomized controlled trials. J Psychiatr Res (2020) 120:113–23. Elsevier Ltd. 10.1016/j.jpsychires.2019.10.009
    1. Silver J, Baima J, Mayer R. Impairment-Driven Cancer Rehabilitation. A Cancer J Clin (2013) 63(5):295–317. 10.3322/caac.21186
    1. Moore GF, Audrey S, Barker M, Bond L, Bonell C, Hardeman W, et al. Process evaluation of complex interventions: Medical Research Council guidance. BMJ (2015) 350:h1258. 10.1136/bmj.h1258
    1. Huang GH, Ismail H, Murnane A, Kim P, Riedel B. Structured exercise program prior to major cancer surgery improves cardiopulmonary fitness: a retrospective cohort study. Support Care Cancer (2016) 24(5):2277–85. 10.1007/s00520-015-3028-7
    1. Patient@Home [Internet]. (2012). Available from: .
    1. Akiyama Y, Sasaki A, Fujii Y, Fujisawa R, Sasaki N, Nikai H, et al. Efficacy of enhanced prehabilitation for patients with esophageal cancer undergoing esophagectomy. Esophagus (2020) 1–9. 10.1007/s10388-020-00757-2
    1. Souwer ETD, Bastiaannet E, de Bruijn S, Breugom AJ, van den Bos F, Portielje JEA, et al. Comprehensive multidisciplinary care program for elderly colorectal cancer patients: “From prehabilitation to independence.” Eur J Surg Oncol (2018) 44(12):1894–900. 10.1016/j.ejso.2018.08.028
    1. Baltaxe E, Cano I, Herranz C, Barberan-Garcia A, Hernandez C, Alonso A, et al. Evaluation of integrated care services in Catalonia: Population-based and service-based real-life deployment protocols. BMC Health Serv Res (2019) 19(1):1–11. 10.1186/s12913-019-4174-2
    1. Moore J, Merchant Z, Rowlinson K, McEwan K, Evison M, Faulkner G, et al. Implementing a system-wide cancer prehabilitation programme: The journey of Greater Manchester’s ‘Prehab4cancer.’. Eur J Surg Oncol (2020) 0(0):1–9. 10.1016/j.ejso.2020.04.042
    1. Dewberry LC, Wingrove LJ, Marsh MD, Glode AE, Schefter TE, Leong S, et al. Pilot Prehabilitation Program for Patients With Esophageal Cancer During Neoadjuvant Therapy and Surgery. J Surg Res (2019) 235:66–72. 10.1016/j.jss.2018.09.060
    1. Englesbe MJ, Grenda DR, Sullivan JA, Derstine BA, Kenney BN, Sheetz KH, et al. The Michigan Surgical Home and Optimization Program is a scalable model to improve care and reduce costs. Surgery (United States) (2017) 161(6):1659–66. 10.1016/j.surg.2016.12.021

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