Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation
C Holmes, C Ballard, D Lehmann, A David Smith, H Beaumont, I N Day, M Nadeem Khan, S Lovestone, M McCulley, C M Morris, D G Munoz, K O'Brien, C Russ, T Del Ser, D Warden, C Holmes, C Ballard, D Lehmann, A David Smith, H Beaumont, I N Day, M Nadeem Khan, S Lovestone, M McCulley, C M Morris, D G Munoz, K O'Brien, C Russ, T Del Ser, D Warden
Abstract
Objective: To determine whether individuals with Alzheimer's disease (AD) and the K variant allele of butyrylcholinesterase have a slower rate of cognitive decline than those without the K variant allele of butyrylcholinesterase.
Method: The cognitive status of 339 community based subjects with AD was assessed with the Mini Mental State Examination at baseline and yearly over a three year follow up period. The rates of cognitive decline of subjects with and without the K variant allele were compared.
Result: Presence of the K allele was associated with a slower average rate of cognitive decline in subjects with severe AD.
Conclusions: This finding is consistent with the suggestion that the K variant of butyrylcholinesterase has an important role in disease progression in AD, and this may have implications for treatment.
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Source: PubMed