The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation
Camille N Kotton, Deepali Kumar, Angela M Caliendo, Shirish Huprikar, Sunwen Chou, Lara Danziger-Isakov, Atul Humar, The Transplantation Society International CMV Consensus Group, Camille N Kotton, Atul Humar, Angela M Caliendo, Randall Hayden, Hans Hirsch, Tiziana Lazzarotto, Jutta Preiksaitis, Deepali Kumar, Davide Abate, Oriol Bestard, Javier Carbone, Hannah Kaminski, Rajiv Khanna, Martina Sester, Atul Humar, Camille N Kotton, Laura Barcan, Emily Blumberg, Jennifer Harrison, Nassim Kamar, Nicolas Mueller, Tomas Reischig, Nina Singh, David Snydman, Helio Tedesco-Silva, David Thomson, Marty Zamora, Shirish Huprikar, Jay Fishman, Shahid Husain, Michele Morris, Claudia Nagel, William Rawlinson, Sunwen Chou, Sophie Alain, Guy Boivin, Klaus Hamprecht, Ajit P Limaye, Lara Danziger-Isakov, Upton Allen, Michael Green, Britta Hoecker, Rebecca Madan, Gustavo Varela-Fascinetto, Camille N Kotton, Deepali Kumar, Angela M Caliendo, Shirish Huprikar, Sunwen Chou, Lara Danziger-Isakov, Atul Humar, The Transplantation Society International CMV Consensus Group, Camille N Kotton, Atul Humar, Angela M Caliendo, Randall Hayden, Hans Hirsch, Tiziana Lazzarotto, Jutta Preiksaitis, Deepali Kumar, Davide Abate, Oriol Bestard, Javier Carbone, Hannah Kaminski, Rajiv Khanna, Martina Sester, Atul Humar, Camille N Kotton, Laura Barcan, Emily Blumberg, Jennifer Harrison, Nassim Kamar, Nicolas Mueller, Tomas Reischig, Nina Singh, David Snydman, Helio Tedesco-Silva, David Thomson, Marty Zamora, Shirish Huprikar, Jay Fishman, Shahid Husain, Michele Morris, Claudia Nagel, William Rawlinson, Sunwen Chou, Sophie Alain, Guy Boivin, Klaus Hamprecht, Ajit P Limaye, Lara Danziger-Isakov, Upton Allen, Michael Green, Britta Hoecker, Rebecca Madan, Gustavo Varela-Fascinetto
Abstract
Despite recent advances, cytomegalovirus (CMV) infections remain one of the most common complications affecting solid organ transplant recipients, conveying higher risks of complications, graft loss, morbidity, and mortality. Research in the field and development of prior consensus guidelines supported by The Transplantation Society has allowed a more standardized approach to CMV management. An international multidisciplinary panel of experts was convened to expand and revise evidence and expert opinion-based consensus guidelines on CMV management including prevention, treatment, diagnostics, immunology, drug resistance, and pediatric issues. Highlights include advances in molecular and immunologic diagnostics, improved understanding of diagnostic thresholds, optimized methods of prevention, advances in the use of novel antiviral therapies and certain immunosuppressive agents, and more savvy approaches to treatment resistant/refractory disease. The following report summarizes the updated recommendations.
Source: PubMed