Whole Body Vibration Training on Muscle Strength and Brain-Derived Neurotrophic Factor Levels in Elderly Woman With Knee Osteoarthritis: A Randomized Clinical Trial Study

Adriano Prado Simão, Vanessa Amaral Mendonça, Núbia Carelli Pereira Avelar, Sueli Ferreira da Fonseca, Jousielle Márcia Santos, Ana Carolina Coelho de Oliveira, Rosalina Tossige-Gomes, Vanessa Gonçalves César Ribeiro, Camila Danielle Cunha Neves, Cláudio Heitor Balthazar, Hércules Ribeiro Leite, Pedro Henrique Scheidt Figueiredo, Mário Bernardo-Filho, Ana Cristina Rodrigues Lacerda, Adriano Prado Simão, Vanessa Amaral Mendonça, Núbia Carelli Pereira Avelar, Sueli Ferreira da Fonseca, Jousielle Márcia Santos, Ana Carolina Coelho de Oliveira, Rosalina Tossige-Gomes, Vanessa Gonçalves César Ribeiro, Camila Danielle Cunha Neves, Cláudio Heitor Balthazar, Hércules Ribeiro Leite, Pedro Henrique Scheidt Figueiredo, Mário Bernardo-Filho, Ana Cristina Rodrigues Lacerda

Abstract

Background: Osteoarthritis of the knee (kOA) is a chronic, progressive, degenerative health condition that contributes to the imbalance between the synthesis and destruction of articular cartilage. Recently, whole body vibration (WBV) training has been recommended as an effective alternative for strength training in elderly people, and various physiological effects are obtained in response to exercise performed on a vibratory platform, such as an increase in muscle activation and improved muscle performance. However, the effects of WBV particularly on the strength of the quadriceps muscle and neuronal plasticity are unknown. Objective: The aim of this study was to evaluate the effects of adding WBV to squat training on the isometric quadriceps muscle strength (IQMS) and the plasma levels of brain-derived neurotrophic factor (BDNF) in elderly woman with kOA. Methods: Fifteen elderly women ≥65 years of age with kOA were randomized into two interventions: (1) the vibration group (VG), in which participants performed squat exercise training in association with WBV or (2) the exercise group (EG), in which participants performed squat exercise training without vibration, for 12 weeks 3×/week. Results: Compared to the EG group, the VG group demonstrated a significantly greater delta (Δ) in IQMS values (IC95% 0.43-7.06; p ≤ 0.05) and in Δ BDNF plasma levels (IC95% -32.51 to 4.217; p ≤ 0.05) after the intervention period. There was an association between increase of Δ BDNF plasma levels and increase of Δ IQMS (β = 0.57; R 2 = 0.32; p = 0.03). Conclusion: The addition of WBV to squat exercise training improves lower limb muscle performance in elderly women with kOA. These findings suggest that the improvement in muscle performance is related to neuromuscular adaptations induced by WBV. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03918291.

Keywords: brain-derived neurotrophic factor; muscle strength; osteoarthritis of knee; squat; whole body vibration.

Figures

Figure 1
Figure 1
The study flow chart. OA, osteoarthritis; VG, vibration group; EG, exercise group; WBV, whole body vibration.
Figure 2
Figure 2
The delta (Δ) in isometric quadriceps muscle strength (IQMS) in the vibration group (VG) and exercise group (EG). The data are presented as the mean and standard error. *VG is significantly different from EG (p ≤ 0.05). Data are presented in delta (Δ), i.e., the variation between the values measured before and after the intervention period (independent t-test).
Figure 3
Figure 3
The delta (Δ) in brain-derived neurotrophic factor (BDNF) in the vibration group (VG) and exercise group (EG). The data are presented as the mean and standard error. *VG is significantly different from EG (p ≤ 0.05). Data are presented in delta (Δ), i.e., the variation between the values measured before and after the intervention period (independent t-test).
Figure 4
Figure 4
Correlation between the delta (Δ) of the isometric quadriceps muscle strength (IQMS) and plasma concentration of brain-derived neurotrophic factor (BDNF) in older women with osteoarthritis (OA) of the knee. β, standardized regression coefficient; R2, R square (Pearson correlation).

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