Global Consensus Position Statement on the Use of Testosterone Therapy for Women

Susan R Davis, Rodney Baber, Nicholas Panay, Johannes Bitzer, Sonia Cerdas Perez, Rakibul M Islam, Andrew M Kaunitz, Sheryl A Kingsberg, Irene Lambrinoudaki, James Liu, Sharon J Parish, JoAnn Pinkerton, Janice Rymer, James A Simon, Linda Vignozzi, Margaret E Wierman, Susan R Davis, Rodney Baber, Nicholas Panay, Johannes Bitzer, Sonia Cerdas Perez, Rakibul M Islam, Andrew M Kaunitz, Sheryl A Kingsberg, Irene Lambrinoudaki, James Liu, Sharon J Parish, JoAnn Pinkerton, Janice Rymer, James A Simon, Linda Vignozzi, Margaret E Wierman

Abstract

This Position Statement has been endorsed by the International Menopause Society, The Endocrine Society, The European Menopause and Andropause Society, The International Society for Sexual Medicine, The International Society for the Study of Women's Sexual Health, The North American Menopause Society, The Federacion Latinoamericana de Sociedades de Climaterio y Menopausia, The Royal College of Obstetricians and Gynecologists, The International Society of Endocrinology, The Endocrine Society of Australia, and The Royal Australian and New Zealand College of Obstetricians and Gynecologists.

Conflict of interest statement

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

Copyright © 2019 The Author(s), Published by the Endocrine Society.

References

    1. Islam MR, Bell RJ, Green S, Page M, Davis SR. Efficacy and safety of testosterone therapy for women: a systematic review and meta-analysis of randomized controlled trails. Lancet Diabetes Endocrinol. In press.
    1. Shekelle PG, Woolf SH, Eccles M, Grimshaw J. Developing clinical guidelines. West J Med. 1999;170(6):348–351.
    1. Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab. 2005;90(7):3847–3853.
    1. Haring R, Hannemann A, John U, Radke D, Nauck M, Wallaschofski H, Owen L, Adaway J, Keevil BG, Brabant G. Age-specific reference ranges for serum testosterone and androstenedione concentrations in women measured by liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab. 2012;97(2):408–415.
    1. Cappola AR, Ratcliffe SJ, Bhasin S, Blackman MR, Cauley J, Robbins J, Zmuda JM, Harris T, Fried LP. Determinants of serum total and free testosterone levels in women over the age of 65 years. J Clin Endocrinol Metab. 2007;92(2):509–516.
    1. Wang C, Catlin DH, Demers LM, Starcevic B, Swerdloff RS. Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab. 2004;89(2):534–543.
    1. Groenestege WM, Bui HN, ten Kate J, Menheere PP, Oosterhuis WP, Vader HL, Heijboer AC, Janssen MJ. Accuracy of first and second generation testosterone assays and improvement through sample extraction. Clin Chem. 2012;58(7):1154–1156.
    1. Rosner W, Vesper H;. Endocrine Society; American Association for Clinical Chemistry; American Association of Clinical Endocrinologists; Androgen Excess/PCOS Society; American Society for Bone and Mineral Research; American Society for Reproductive Medicine; American Urological Association; Association of Public Health Laboratories; Endocrine Society; Laboratory Corporation of America; North American Menopause Society; Pediatric Endocrine Society. Toward excellence in testosterone testing: a consensus statement. J Clin Endocrinol Metab. 2010;95(10):4542–4548.
    1. Goldman AL, Bhasin S, Wu FCW, Krishna M, Matsumoto AM, Jasuja R. A reappraisal of testosterone’s binding in circulation: physiological and clinical implications. Endocr Rev. 2017;38(4):302–324.
    1. Clayton AH, Goldstein I, Kim NN, Althof SE, Faubion SS, Faught BM, Parish SJ, Simon JA, Vignozzi L, Christiansen K, Davis SR, Freedman MA, Kingsberg SA, Kirana PS, Larkin L, McCabe M, Sadovsky R. The International Society for the Study of Women’s Sexual Health Process of Care for Management of Hypoactive Sexual Desire Disorder in Women. Mayo Clin Proc. 2018;93(4):467–487.
    1. Simon JA, Davis SR, Althof SE, Chedraui P, Clayton AH, Kingsberg SA, Nappi RE, Parish SJ, Wolfman W. Sexual well-being after menopause: an International Menopause Society White Paper. Climacteric. 2018;21(5):415–427.
    1. Parish SJ, Meston CM, Althof SE, Clayton AH, Goldstein I, Goldstein SW, Heiman JR, McCabe MP, Segraves RT, Simon JA. Toward a more evidence-based nosology and nomenclature for female sexual dysfunctions-part III. J Sex Med. 2019;16(3):452–462.
    1. Parish SJ, Goldstein AT, Goldstein SW, Goldstein I, Pfaus J, Clayton AH, Giraldi A, Simon JA, Althof SE, Bachmann G, Komisaruk B, Levin R, Spadt SK, Kingsberg SA, Perelman MA, Waldinger MD, Whipple B. Toward a more evidence-based nosology and nomenclature for female sexual dysfunctions-part II. J Sex Med. 2016;13(12):1888–1906.
    1. Sexual dysfunctions, in 17 conditions related to sexual health. ICD-11 for Mortality and Morbidity Statistics. Available at: . Accessed 22 July 2019.
    1. Davis SR, Davison SL, Donath S, Bell RJ. Circulating androgen levels and self-reported sexual function in women. JAMA. 2005;294(1):91–96.
    1. Achilli C, Pundir J, Ramanathan P, Sabatini L, Hamoda H, Panay N. Efficacy and safety of transdermal testosterone in postmenopausal women with hypoactive sexual desire disorder: a systematic review and meta-analysis. Fertil Steril. 2017;107:475–482.
    1. Kingsberg SA, Althof S, Simon JA, Bradford A, Bitzer J, Carvalho J, Flynn KE, Nappi RE, Reese JB, Rezaee RL, Schover L, Shifrin JL. Female sexual dysfunction-medical and psychological treatments, committee 14 (published correction appears in J Sex Med. 2018;15(2):270). J Sex Med. 2017;14(12):1463–1491.
    1. Elraiyah T, Sonbol MB, Wang Z, Khairalseed T, Asi N, Undavalli C, Nabhan M, Altayar O, Prokop L, Montori VM, Murad MH. Clinical review: the benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2014;99(10):3536–3542.

Source: PubMed

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