18F-6-Fluoro-l-Dopa PET/CT Imaging of Congenital Hyperinsulinism
Lisa J States, J Christopher Davis, Steven M Hamel, Susan A Becker, Hongming Zhuang, Lisa J States, J Christopher Davis, Steven M Hamel, Susan A Becker, Hongming Zhuang
Abstract
Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyperinsulinemic hypoglycemia. The clinical course varies from mild to severe, with a significant risk for brain damage. Imaging plays a valuable role in the care of infants and children with severe hypoglycemia unresponsive to medical therapy. 18F-6-fluoro-l-dopa PET/CT is the method of choice for the detection and localization of a focal lesion of hyperinsulinism. Surgical resection of a focal lesion can lead to a cure with limited pancreatectomy. This article reviews the role of 18F-6-fluoro-l-dopa PET/CT in the management of this vulnerable population.
Trial registration: ClinicalTrials.gov NCT01916148.
Keywords: 18F-FDOPA; congenital hyperinsulinism; hyperinsulinism.
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.
Source: PubMed