Guideline for the management of hip fractures 2020: Guideline by the Association of Anaesthetists

R Griffiths, S Babu, P Dixon, N Freeman, D Hurford, E Kelleher, I Moppett, D Ray, O Sahota, M Shields, S White, R Griffiths, S Babu, P Dixon, N Freeman, D Hurford, E Kelleher, I Moppett, D Ray, O Sahota, M Shields, S White

Abstract

We convened a multidisciplinary Working Party on behalf of the Association of Anaesthetists to update the 2011 guidance on the peri-operative management of people with hip fracture. Importantly, these guidelines describe the core aims and principles of peri-operative management, recommending greater standardisation of anaesthetic practice as a component of multidisciplinary care. Although much of the 2011 guidance remains applicable to contemporary practice, new evidence and consensus inform the additional recommendations made in this document. Specific changes to the 2011 guidance relate to analgesia, medicolegal practice, risk assessment, bone cement implantation syndrome and regional review networks. Areas of controversy remain, and we discuss these in further detail, relating to the mode of anaesthesia, surgical delay, blood management and transfusion thresholds, echocardiography, anticoagulant and antiplatelet management and postoperative discharge destination. Finally, these guidelines provide links to supplemental online material that can be used at readers' institutions, key references and UK national guidance about the peri-operative care of people with hip and periprosthetic fractures during the COVID-19 pandemic.

Keywords: Hip fracture, anaesthesia; Hip fracture, anticoagulation; Hip fracture, complications; Hip fracture, guidelines; Hip fracture, mortality; Hip fracture, peri-operative management.

© 2020 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.

References

    1. White SM, Altermatt F, Barry J, et al. International Fragility Fracture Network consensus statement on the principles of anaesthesia for patients with hip fracture. Anaesthesia 2018; 73: 863-74.
    1. Griffiths R, Alper J, Beckingsale A, et al. Management of proximal femoral fractures 2011. Anaesthesia 2011; 67: 85-98.
    1. Griffiths R, Beech F, Brown A, et al. Peri-operative care of the elderly 2014. Anaesthesia 2014; 69(Suppl 1): 81-98.
    1. Griffiths R, White SM, Moppett IK, et al. Safety guideline: reducing the risk from cemented hemiarthroplasty for hip fracture 2015. Anaesthesia 2015; 70: 623-6.
    1. White SM, Griffiths R, Baxter M, et al. Guidelines for the peri-operative care of people with dementia. Anaesthesia 2019; 74: 357-72.
    1. NHS England. Clinical guide for the perioperative care of people with fragility fractures during the Coronavirus pandemic. 2020. (accessed 01/07/2020).
    1. FICM, ICS, AoA, RCoA. Perioperative care of patients with hip and major fragility fractures during the COVID-19 pandemic. A consensus statement. 2020. (accessed 01/07/2020).
    1. National Hip Fracture Database. Annual Report. 2019. (accessed 01/07/2020).
    1. Scottish Hip Fracture Audit. Hip fracture care pathway report 2019. (accessed 01/07/2020).
    1. Irish Hip Fracture Database. National Report 2017. (accessed 01/07/2020).
    1. White SM, Moppett IK, Griffiths R. Standardising anaesthesia for hip fracture surgery. Anaesthesia 2016; 71: 1391-5.
    1. British Orthopaedic Association. Standards for Trauma and Orthopaedics (BOAST). The care of the Older or Frail Orthopaedic Trauma Patient. (accessed 01/07/2020).
    1. National Hip Fracture Database dashboards. (accessed 01/07/2020).
    1. National Institute for Health and Care Excellence. Hip Fracture in Adults. Quality Standard 16 (QS16). May, 2017. (accessed 01/07/2020).
    1. The National Institute of Clinical Excellence. Clinical Guideline 124. The management of hip fracture in adults. 2011. (accessed 01/07/2020).
    1. Neuman MD, Ellenberg SS, Sieber FE, Magaziner JS, Feng R, Carson JL. Regional versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN): protocol for a pragmatic, international multicentre trial. British Medical Journal Open 2016; 6: e013473.
    1. Kowark A, Adam C, Ahrens J, et al. Improve hip fracture outcome in the elderly patient (iHOPE): a study protocol for a pragmatic, multicentre randomised controlled trial to test the efficacy of spinal versus general anaesthesia. British Medical Journal Open 2018; 8: e023609.
    1. Li T, Yeung J, Li J, et al. Comparison of regional with general anaesthesia on postoperative delirium (RAGA-delirium) in the older patients undergoing hip fracture surgery: study protocol for a multicentre randomised controlled trial. British Medical Journal Open 2017; 7: e016937.
    1. Royal College of Physicians and the Association of Anaesthetists. National Hip Fracture Database. Anaesthesia Sprint Audit of Practice. 2014. (accessed 01/07/2020).
    1. White SM, Moppett IK, Griffiths R, et al. Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP 2). Anaesthesia 2016; 71: 506-14.
    1. O'Donnell CM, McLoughlin L, Patterson CC, et al. Perioperative outcomes in the context of mode of anaesthesia for patients undergoing hip fracture surgery: systematic review and meta-analysis. British Journal of Anaesthesia 2018; 120: 37-50.
    1. Wesselink EM, Kappen TH, Torn HM, Slooter AJC, van Klei WA. Intraoperative hypotension and the risk of postoperative adverse outcomes: a systematic review. British Journal of Anaesthesia 2018; 121: 706-21.
    1. O'Donnell CM, Black N, McCourt KC, et al. Development of a Core Outcome Set for studies evaluating the effects of anaesthesia on perioperative morbidity and mortality following hip fracture surgery. British Journal of Anaesthesia 2019; 122: 120-30.
    1. Chuan A, Zhao L, Tilekeratne N, et al. The effect of a multidisciplinary care bundle on the incidence of delirium after hip fracture surgery: a quality improvement study. Anaesthesia 2020; 75: 63-71.
    1. Foss NB, Kristensen BB, Bundgaard M, et al. Fascia iliaca compartment blockade for acute pain control in hip fracture patients: a randomized, placebo-controlled trial. Anesthesiology 2007; 106: 773-8.
    1. Reavley P, Montgomery AA, Smith JE, et al. Randomised trial of the fascia iliaca block versus the '3-in-1' block for femoral neck fractures in the emergency department. Emergency Medical Journal 2015; 32: 685-9.
    1. Guay J, Parker MJ, Griffiths R, Kopp SL. Peripheral nerve blocks for hip fractures: a Cochrane review. Anesthesia and Analgesia 2018; 126: 1695-704.
    1. Harrop-Griffiths W, Cook T, Gill H, et al. Regional anaesthesia and patients with abnormalities of coagulation. Anaesthesia 2013; 68: 966-72.
    1. Hards M, Brewer A, Bessant G, Lahiri S. Efficacy of prehospital analgesia with fascia iliaca compartment block for femoral bone fractures: a systematic review. Prehospital and Disaster Medicine 2018; 33: 299-307.
    1. Social Care Institute for Excellence. Deprivation of Liberty Safeguards. (accessed 01/07/2020).
    1. British Medical Association, Resuscitation Council (UK), Royal College of Nursing. Decisions relating to cardiopulmonary resuscitation. 3rd edn (1st revision), 2016. (accessed 01/07/2020).
    1. Yentis SM, Hartle AJ, Barker IR, et al. AAGBI: Consent for anaesthesia 2017. Anaesthesia 2017; 72: 93-105.
    1. Resuscitation Council (UK). Recommended Summary Plan for Emergency Care and Treatment (ReSPECT). (accessed 01/07/2020).
    1. General Medical Council. Consent: patients and doctors making decisions together. 2008. (accessed 01/07/2020).
    1. Fernandez M, Arnel L, Gould G, et al. Research priorities in fragility fractures of the lower limb and pelvis: a UK Priority Setting Partnership with the James Lind Alliance. British Medical Journal Open 2018; 8: e023301.
    1. Maxwell MJ, Moran CG, Moppett IK. Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. British Journal of Anaesthesia 2008; 101: 511-7.
    1. Moppett IK, Parker M, Griffiths R, Bowers T, White SM, Moran CG. Nottingham Hip Fracture Score: longitudinal and multi-assessment. British Journal of Anaesthesia 2012; 109: 546-50.
    1. Marufu TC, White SM, Griffiths RG, Moonesinghe R, Moppett IK. Comparison of the Nottingham Hip Fracture Score (NHFS) with the Surgical Outcome Risk Tool (SORT) in predicting 30-day mortality after hip fracture surgery. Anaesthesia 2016; 71: 515-21.
    1. Tsang C, Cromwell D. Statistical methods developed for the National Hip Fracture Database annual report, 2014: a technical report. London: The Royal College of Surgeons of England, 2014. (accessed 01/07/2020).
    1. Krishnan M, Beck S, Havelock W, Eeles E, Hubbard RE, Johansen A. Predicting outcome after hip fracture: using a frailty index to integrate comprehensive geriatric assessment results. Age and Ageing 2014; 43: 122-6.
    1. Bellelli G, Morandi A, Davis DH, et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age and Ageing 2014; 43: 496-502.
    1. Porter CJ, Moppett IK, Juurlink I, Nightingale J, Moran CG, Devonald MA. Acute and chronic kidney disease in elderly patients with hip fracture: prevalence, risk factors and outcome with development and validation of a risk prediction model for acute kidney injury. BMC Nephrology 2017; 18: 20.
    1. Shiga T, Wajima Z, Ohe Y. Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Canadian Journal of Anesthesia 2008; 55: 146-54.
    1. Khan SK, Kalra S, Khanna A, Thiruvengada MM, Parker MJ. Timing of surgery for hip fractures: a systematic review of 52 published studies involving 291,413 patients. Injury 2009; 40: 692-7.
    1. HIP Attack investigators. Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial. Lancet 2020; 395: 698-708.
    1. Carson JL, Terrin ML, Noveck H, et al.; FOCUS Investigators. Liberal or restrictive transfusion in high-risk patients after hip surgery. New England Journal of Medicine 2011; 365: 2453-62.
    1. Carson JL, Sieber F, Cook DR, et al. Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial. Lancet 2015; 385: 1183-9.
    1. Carson JL, Carless PA, Hebert PC. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database of Systematic Reviews 2012; 4: CD002042.
    1. Carson JL, Stanworth SJ, Roubinian N, et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database of Systematic Reviews 2016; 10: CD002042.
    1. Hovaguimian F, Myles PS. Restrictive versus liberal transfusion strategy in the perioperative and acute care settings: a context-specific systematic review and meta-analysis of randomized controlled trials. Anesthesiology 2016; 125: 46-61.
    1. Brunskill SJ, Millette SL, Shokoohi A, et al. Red blood cell transfusion for people undergoing hip fracture surgery. Cochrane Database of Systematic Reviews 2015; 4: CD009699.
    1. Foss NB, Kristensen MT, Kehlet H. Anaemia impedes functional mobility after hip fracture surgery. Age and Ageing 2008; 37: 173-8.
    1. Gregersen M. Postoperative red blood cell transfusion strategy in frail anemic elderly with hip fracture. A randomized controlled trial. Danish Medical Journal 2016; 63: pii: B5221.
    1. Canty DJ, Royse CF, Kilpatrick D, Bowyer A, Royse AG. The impact on cardiac diagnosis and mortality of focused transthoracic echocardiography in hip fracture surgery patients with increased risk of cardiac disease: a retrospective cohort study. Anaesthesia 2012; 67: 1202-9.
    1. Loxdale SJ, Sneyd JR, Donovan A, Werrett G, Viira DJ. The role of routine pre-operative bedside echocardiography in detecting aortic stenosis in patients with a hip fracture. Anaesthesia 2012; 67: 51-4.
    1. Yonekura H, Ide K, Onishi Y, Nahara I, Takeda C, Kawakami K. Preoperative echocardiography for patients with hip fractures undergoing surgery: a retrospective cohort study using a nationwide database. Anesthesia and Analgesia 2019; 128: 213-20.
    1. Canty DJ, Heiberg J, Yang Y, et al. Pilot multi-centre randomised trial of the impact of pre-operative focused cardiac ultrasound on mortality and morbidity in patients having surgery for femoral neck fractures (ECHONOF-2 pilot). Anaesthesia 2018; 73: 428-37.
    1. Canty DJ, Heiberg J, Yang Y, et al. One-year results of the pilot multicentre randomised trial of preoperative focused cardiac ultrasound in hip fracture surgery. Anaesthesia and Intensive Care 2019; 47: 207-8.
    1. Rostagno C, Ranalli C, Polidori G, Cartei A, Boccaccini A, Peris A. Outcome in elderly patients with aortic stenosis undergoing hip fracture surgery. Results may suggest a different postoperative strategy? Trauma Surgery and Acute Care Open 2019; 4: e000218.
    1. Collinge CA, Kelly KC, Little B, Weaver T, Schuster RD. The effects of clopidogrel (Plavix) and other oral anticoagulants on early hip fracture surgery. Journal of Orthopaedic Trauma 2012; 26: 568-73.
    1. Daugaard C, Pedersen AB, Kristensen NR, Johnsen SP. Preoperative antithrombotic therapy and risk of blood transfusion and mortality following hip fracture surgery: a Danish nationwide cohort study. Osteoporosis International 2019; 30: 583-91.
    1. Hoerlyck C, Ong T, Gregersen M, et al. Do anticoagulants affect outcomes of hip fracture surgery? A cross-sectional analysis. Archives of Orthopaedic and Trauma Surgery 2019; 140: 171-6.
    1. Cook TM, Counsell D, Wildsmith JA; Royal College of Anaesthetists Third National Audit Project. Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists. British Journal of Anaesthesia 2009; 102: 179-90.
    1. Hewson DW, Bedforth NM, Hardman JG. Spinal cord injury arising in anaesthesia practice. Anaesthesia 2018; 73(Suppl 1): 43-50.
    1. Park JH, Han SW, Lee K-Y, et al. Impact of non-vitamin K antagonist oral anticoagulant withdrawal on stroke outcomes. Frontiers in Neurology 2018; 9: 1095.
    1. Ford I. Coming safely to a stop: a review of platelet activity after cessation of antiplatelet drugs. Therapeutic Advances in Drug Safety 2015; 6: 141-50.
    1. Chassot PG, Delabays A, Spahn DR. Perioperative antiplatelet therapy: the case for continuing therapy in patients at risk of myocardial infarction. British Journal of Anaesthesia 2007; 99: 316-28.
    1. Pincus D, Ravi B, Wasserstein D, et al. Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. Journal of the American Medical Association 2017; 318: 1994-2003.
    1. Klestil T, Röder C, Stotter C, et al. Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Scientific Reports 2018; 8: 13933.
    1. Gibson AA, Hay AW, Ray DC. Patients with hip fracture admitted to critical care: epidemiology, interventions and outcome. Injury 2014; 45: 1066-70.
    1. Fliss E, Weinstein O, Sherf M, Dreiher J. Healthcare services utilization following admission for hip fracture in elderly patients. International Journal for Quality in Health Care 2018; 30: 104-9.
    1. Åhman R, Siverhall PF, Snygg J, et al. Determinants of mortality after hip fracture surgery in Sweden: a registry-based retrospective cohort study. Scientific Reports 2018; 8: 15695.
    1. Yeung J.REGARD study - a feasibility randomised controlled trial of Regional versus General anaesthesia on post-operative delirium in patients with hip fractures. (accessed 01/07/2020).
    1. Leavey N, Hammond SP, Shepstone L, et al. Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients. BMC Neurology 2019; 19: 223.
    1. Moppett IK, White S, Griffiths R, Buggy D. Tight intra-operative blood pressure control versus standard care for patients undergoing hip fracture repair - Hip Fracture Intervention Study for Prevention of Hypotension (HIP-HOP) trial: study protocol for a randomised controlled trial. Trials 2017; 18: 350.
    1. Griffin XL, Achten J, Parsons N, Boardman F, Griffiths F, Costa ML. The Warwick Hip Trauma Evaluation - an abridged protocol for the WHiTE Study: a multiple embedded randomised controlled trial cohort study. Bone and Joint Research 2012; 1: 310-4.
    1. Moppett I. Hip fractures: are we asking the right questions? Age and Ageing 2018; 47: 633-4.
    1. Metcalfe D, Costa ML, Parsons NR, et al. Validation of a prospective cohort study of older adults with hip fractures. Bone and Joint Journal 2019; 101-B: 708-14.
    1. Hip Fracture Perioperative Network (HiPPEN). (accessed 01/01/2020).
    1. Fragility Fractures Network. (accessed 01/07/2020).
    1. National Hip Fracture Database. (accessed 01/07/2020).
    1. Irish Hip Fracture Database. (accessed 01/07/2020).
    1. Scottish Hip Fracture Audit. (accessed 01/07/2020).

Source: PubMed

3
Abonnieren