Vitamin A and E Nutritional Status in Relation to Leptin, Adiponectin, IGF-I and IGF-II in Early Life - a Birth Cohort Study
Qinwen Du, Zhong-Cheng Luo, Anne Monique Nuyt, Francois Audibert, Pierre Julien, Shu-Qin Wei, Dan-Li Zhang, William Fraser, Emile Levy, Qinwen Du, Zhong-Cheng Luo, Anne Monique Nuyt, Francois Audibert, Pierre Julien, Shu-Qin Wei, Dan-Li Zhang, William Fraser, Emile Levy
Abstract
The metabolic health effects of vitamin A and E nutritional status in early life are largely unknown. We assessed whether vitamin A and vitamin E nutritional status may affect circulating leptin, adiponectin, insulin-like growth factor (IGF)-I and IGF-II levels in early life in humans. In a singleton birth cohort (n = 248), vitamin A and E nutritional status in fetuses/newborns were assessed by cord plasma concentrations of retinol, β-carotene, α- and γ-tocopherols. The primary outcomes were cord plasma leptin, adiponectin, IGF-I and IGF-II concentrations. Cord plasma retinol was significantly positively correlated to IGF-I in girls (r = 0.42, P < 0.0001) but not in boys (r = 0.14, P = 0.11). Adjusting for maternal and newborn's characteristics, one log unit increase in cord plasma retinol was associated with a 28.0% (95% CI: 11.1-47.5%) increase in IGF-I in girls (P < 0.001) but not in boys (P = 0.75). One log unit increment in cord plasma α-tocopherol was associated with a 6.6% (0.4-12.3%) decrease in adiponectin (P = 0.04), while one log unit increment in cord plasma γ-tocopherol was associated with a 21.2% (4.7-34.8%) decrease in leptin (P = 0.01). There may be a sex-specific association between retinol and IGF-I, a negative association between α-tocopherol and adiponectin, and a negative association between γ-tocopherol and leptin in early life in humans.
Conflict of interest statement
The authors declare that they have no competing interests.
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References
- Becker W, et al. Nordic Nutrition Recommendations 2004-integrating nutrition and physical activity. Scand J Nutr. 2004;48:178–187. doi: 10.1080/1102680410003794.
- Otten, J. J., Hellwig, J. P. & Meyers, L. D. Dietary reference intakes: the essential guide to nutrient requirements –part III vitamins and minerals. National Academies Press, pp 167–462, 2006.
- Ford ES, Schleicher RL, Mokdad AH, Ajani UA, Liu S. Distribution of serum concentrations of α-tocopherol and γ-tocopherol in the US population. Am J Clin Nutr. 2006;84:375–383.
- Tanumihardjo SA, et al. Biomarkers of Nutrition for Development (BOND)-Vitamin A Review. J Nutr. 2016;146:1816S–1848S. doi: 10.3945/jn.115.229708.
- Gagne A, Wei SQ, Fraser WD, Julien P. Absorption, transport, and bioavailability of vitamin e and its role in pregnant women. Obstet Gynaecol Can. 2009;31:210–217. doi: 10.1016/S1701-2163(16)34118-4.
- Tanumihardjo SA. Vitamin A: biomarkers of nutrition for development. Am J Clin Nutr. 2011;94:658S–665S. doi: 10.3945/ajcn.110.005777.
- Jiang Q, Christen S, Shigenaga MK, Ames BN. γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001;74:714–722.
- Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet. 2006;367:1145–1154. doi: 10.1016/S0140-6736(06)68433-X.
- Martín-Estal I, de la Garza R, Castilla-Cortázar I. Intrauterine Growth Retardation (IUGR) as a Novel Condition of Insulin-Like Growth Factor-1 (IGF-1) Deficiency. Rev Physiol Biochem Pharmacol. 2016;170:1–35. doi: 10.1007/112_2015_5001.
- Diener, A. & Rohrmann, S. Associations of serum carotenoid concentrations and fruit or vegetable consumption with serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 concentrations in the Third National Health and Nutrition Examination Survey (NHANES III). J Nutr Sci5 (2016).
- García OP, et al. Zinc, iron and vitamins A, C and E are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children. Nutrients. 2013;5:5012–5030. doi: 10.3390/nu5125012.
- Martins Gregório B, et al. C. The potential role of antioxidants in metabolic syndrome. Curr Pharm Des.n. 2016;22:859–869. doi: 10.2174/1381612822666151209152352.
- Alcalá M, et al. Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity. Obesity. 2015;23:1598–1606. doi: 10.1002/oby.21135.
- Sugiura M, Nakamura M, Ogawa K, Ikoma Y, Yano M. High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects: Mikkabi cohort study. BMJ Open Diabetes Res Care. 2015;3:e000147. doi: 10.1136/bmjdrc-2015-000147.
- Luo Z-C, et al. Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes. The Journal of Clinical Endocrinology & Metabolism. 2012;97:1720–1728. doi: 10.1210/jc.2011-3296.
- Tsai PJ, et al. Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity. Clin Endocrinol. 2004;61:88–93. doi: 10.1111/j.1365-2265.2004.02057.x.
- Luo Z-C, et al. Maternal glucose tolerance in pregnancy affects fetal insulin sensitivity. Diabetes care. 2010;33:2055–2061. doi: 10.2337/dc10-0819.
- Levy E, et al. Altered lipid profile, lipoprotein composition, and oxidant and antioxidant status in pediatric Crohn disease. Am J Clin Nutr. 2000;71:807–815.
- Luo ZC, et al. Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity. Obesity. 2013;21:210–216. doi: 10.1002/oby.20250.
- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care32, S62-S67 (2009).
- Kramer MS, et al. A new and improved population-based Canadian reference for birth weight for gestational age. Pediatrics. 2001;108:e35–e35. doi: 10.1542/peds.108.2.e35.
- Austin PC, Steyerberg EW. The number of subjects per variable required in linear regression analyses. J Clin Epidemiol. 2015;68:627–636. doi: 10.1016/j.jclinepi.2014.12.014.
- Catalano PM, Presley L, Minium J, Hauguel-de Mouzon S. Fetuses of obese mothers develop insulin resistance in utero. Diabetes care. 2009;32:1076–1080. doi: 10.2337/dc08-2077.
- Rabe K, Lehrke M, Parhofer KG, Broedl UC. Adipokines and insulin resistance. Molecular medicine (Cambridge, Mass.) 2008;14:741–751.
- Zhang H, Zhang C. Adipose “talks” to distant organs to regulate insulin sensitivity and vascular function. Obesity. 2010;18:2071–2076. doi: 10.1038/oby.2010.91.
- Simpson J, et al. Programming of Adiposity in Childhood and Adolescence: Associations With Birth Weight and Cord Blood Adipokines. J Clin Endocrinol Metab. 2017;102:499–506.
- Chien CY, et al. Maternal vitamin A deficiency during pregnancy affects vascularized islet development. J Nutr Biochem. 2016;36:51–59. doi: 10.1016/j.jnutbio.2016.07.010.
- McMullen MH, Rowling MJ, Ozias MK, Schalinske KL. Activation and induction of glycine N-methyltransferase by retinoids are tissue-and gender-specific. Arch Biochem Biophys. 2002;401:73–80. doi: 10.1016/S0003-9861(02)00030-9.
- Brown-Borg HM, Rakoczy SG, Uthus EO. Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice. Mech Ageing Dev. 2005;126:389–398. doi: 10.1016/j.mad.2004.09.005.
- Didenco S, et al. Increased vitamin E intake is associated with higher alpha-tocopherol concentration in the maternal circulation but higher alpha-carboxyethyl hydroxychroman concentration in the fetal circulation. Am J Clin Nutr. 2011;93:368–373. doi: 10.3945/ajcn.110.008367.
- Gross MD, Prouty CB, Jacobs D. Stability of carotenoids and alpha-tocopherol during blood collection and processing procedures. Clin Chem. 1995;41:943–944.
- Hankinson S, et al. Effect of transport conditions on the stability of biochemical markers in blood. Clin Chem. 1989;35:2313–2316.
- Masters ET, et al. Relation between prenatal lipid-soluble micronutrient status, environmental pollutant exposure, and birth outcomes. Am J Clin Nutr. 2007;86:1139–1145.
- Weber D, et al. Oxidative stress markers and micronutrients in maternal and cord blood in relation to neonatal outcome. Eur J Clin Nutr. 2014;68:215–222. doi: 10.1038/ejcn.2013.263.
- Scholl TO, Chen X, Sims M, Stein TP. Vitamin E: maternal concentrations are associated with fetal growth. Am J Clin Nutr. 2006;84:1442–1448.
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