Diagnostic markers of infection in neonates

P C Ng, P C Ng

Abstract

Diagnostic markers of infection are useful indicators of neonatal sepsis. Serial measurements of infection markers can improve diagnostic sensitivity, and the use of multiple markers can enhance diagnostic accuracy. Current evidence suggests that promising markers may be useful for early termination of antimicrobial treatment, but none of the current diagnostic tests are sensitive and specific enough to influence the clinical decision for withholding antibiotic treatment at the onset of suspected infection.

References

    1. Lancet. 1998 Mar 28;351(9107):950-3
    1. Pediatr Res. 1998 Oct;44(4):469-77
    1. Lancet. 1998 Oct 17;352(9136):1271-7
    1. Acta Paediatr. 1998 Oct;87(10):1066-9
    1. Ann Surg. 1999 Feb;229(2):246-54
    1. J Matern Fetal Med. 1999 May-Jun;8(3):88-94
    1. Pediatr Res. 1999 Jun;45(6):871-6
    1. Crit Care Med. 1999 Jul;27(7):1262-4
    1. Pediatrics. 1999 Sep;104(3 Pt 1):447-53
    1. Acta Paediatr. 1999 Aug;88(8):880-4
    1. Acta Paediatr. 1997 Oct;86(10):1100-4
    1. Arch Dis Child Fetal Neonatal Ed. 1997 Nov;77(3):F221-7
    1. J Pediatr. 1998 Feb;132(2):295-9
    1. Clin Infect Dis. 1998 Mar;26(3):664-72
    1. J Pediatr. 1998 Mar;132(3 Pt 1):445-51
    1. J Leukoc Biol. 1998 May;63(5):521-33
    1. Lancet. 1998 Apr 18;351(9110):1211-2
    1. Clin Exp Immunol. 1998 Jul;113(1):33-8
    1. Pediatr Infect Dis J. 2000 Sep;19(9):879-87
    1. Am J Respir Crit Care Med. 2002 Apr 1;165(7):992-5
    1. Pediatr Res. 2002 May;51(5):653-7
    1. Pediatrics. 2002 Aug;110(2 Pt 1):285-91
    1. N Engl J Med. 2002 Aug 29;347(9):643-52
    1. Lancet. 2003 Jan 25;361(9354):310-1
    1. Arch Dis Child Fetal Neonatal Ed. 2003 May;88(3):F209-13
    1. Pediatr Res. 2003 Sep;54(3):344-52
    1. Acta Paediatr Scand. 1983 Sep;72(5):679-83
    1. Pediatr Infect Dis J. 1987 May;6(5):443-6
    1. Pediatr Infect Dis J. 2000 Jan;19(1):56-65
    1. Clin Lab Haematol. 1999 Oct;21(5):365-8
    1. Eur J Pediatr. 2000 Mar;159(3):205-10
    1. Ann Allergy Asthma Immunol. 2000 Jul;85(1):9-18; quiz 18, 21
    1. J Pediatr. 2000 Sep;137(3):345-50
    1. J Paediatr Child Health. 2000 Oct;36(5):509-10
    1. Biol Neonate. 2001 Jul;80(1):41-7
    1. Thromb Haemost. 2001 Aug;86(2):543-9
    1. Ann Clin Biochem. 2001 Sep;38(Pt 5):483-93
    1. Acta Paediatr. 2001 Sep;90(9):1025-32
    1. Acta Paediatr. 2001 Oct;90(10):1176-81
    1. J Clin Epidemiol. 2001 Dec;54(12):1251-7
    1. Pediatr Res. 2002 Mar;51(3):296-303
    1. Pediatr Res. 2002 Mar;51(3):317-22
    1. Clin Diagn Lab Immunol. 2002 Mar;9(2):440-5
    1. Ann Clin Biochem. 2002 Mar;39(Pt 2):130-5
    1. J Pediatr. 1988 May;112(5):761-7
    1. Ann Clin Biochem. 1989 Sep;26 ( Pt 5):412-5
    1. Eur J Pediatr. 1990 Mar;149(6):424-7
    1. J Paediatr Child Health. 1990 Oct;26(5):267-70
    1. Br J Surg. 1993 Feb;80(2):205-9
    1. J Clin Invest. 1993 Apr;91(4):1351-7
    1. Pediatrics. 1993 Sep;92(3):431-5
    1. Pediatrics. 1994 Jan;93(1):54-8
    1. Lancet. 1994 May 21;343(8908):1259-60
    1. Clin Sci (Lond). 1994 Aug;87(2):165-71
    1. J Clin Endocrinol Metab. 1994 Dec;79(6):1605-8
    1. Am J Pathol. 1995 Jan;146(1):218-27
    1. Eur J Pediatr. 1995 Feb;154(2):138-44
    1. Acta Paediatr. 1995 Jan;84(1):10-3
    1. Shock. 1995 Mar;3(3):196-203
    1. Pediatr Infect Dis J. 1995 May;14(5):362-6
    1. J Lab Clin Med. 1995 Oct;126(4):330-41
    1. Acta Paediatr. 1995 Jul;84(7):806-8
    1. J Pediatr. 1996 Apr;128(4):570-3
    1. J Pediatr. 1996 Jun;128(6):765-9
    1. J Antimicrob Chemother. 1996 May;37(5):901-9
    1. J Pediatr. 1996 Jul;129(1):72-80
    1. Clin Exp Immunol. 1996 Sep;105(3):551-5
    1. J Pediatr. 1996 Oct;129(4):574-80
    1. Biol Neonate. 1996;70(4):206-12
    1. Pediatrics. 1997 Feb;99(2):216-21
    1. Clin Exp Immunol. 1997 Feb;107(2):306-11
    1. Acta Paediatr. 1997 Feb;86(2):209-12
    1. Pediatr Res. 1997 Mar;41(3):334-9
    1. Acta Paediatr. 1997 Mar;86(3):274-80

Source: PubMed

Sponsoren und Mitarbeiter

Krankheiten

Drogeninterventionen

3
Abonnieren