Impact of Radiation Therapy on Outcomes of Artificial Urinary Sphincter: A Systematic Review and Meta-Analysis

Li Zhang, Yanwen Xu, Li Zhang, Yanwen Xu

Abstract

Background: To compare incontinence rates and complications in patients receiving artificial urinary sphincter (AUS) with or without radiotherapy (RT).

Methods: PubMed, Embase, ScienceDirect, CENTRAL, and Google Scholar databases were searched for studies comparing outcomes of AUS between patients with and without RT. Search limits were from 1st January 2002 to 15th September 2021.

Results: Eighteen studies were included. Meta-analysis revealed statistically significant reduced odds of the absence of incontinence in the RT group (OR: 0.35 95% CI: 0.21, 0.59 I 2 = 51% p < 0.0001) as compared to the no-RT group. We also noted statistically significant increased risk of revision surgery in the RT group (OR: 1.74 95% CI: 1.16, 2.60 I 2 = 73% p = 0.07). There was increased risk of infections (OR: 2.51 95% CI: 1.00, 6.29 I 2 = 46% p = 0.05) and erosions (OR: 2.00 95% CI: 1.15, 3.45 I 2 = 21% p = 0.01) in the RT group, but the difference was significant only for erosions. Meta-analysis revealed a statistically significant increased risk of explantation in patients with RT (OR: 3.00 95% CI: 1.16, 7.75 I 2 = 68% p = 0.02) but there was no difference in the risk of urethral atrophy (OR: 1.18 95% CI: 0.47, 2.94 I 2 = 46% p = 0.72) and mechanical failure (OR: 0.90 95% CI: 0.25, 3.27 I 2 = 54% p = 0.87) between the two groups.

Conclusions: Our meta-analysis of recent studies indicates that RT significantly reduces the odds of achieving complete continence after AUS placement. History of RT does not increase the risk urethral atrophy or mechanical failure in patients with AUS. However, the risk of revision surgery, erosions and explantations is significantly increased in patients with RT with a non-significant but increased tendency of infections.

Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: NCT02612389.

Keywords: EBRT; artificial urinary sphincter; incontinence; meta-analysis; prostate cancer; radiotherapy.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2022 Zhang and Xu.

Figures

Figure 1
Figure 1
Study flow chart.
Figure 2
Figure 2
Meta-analysis of no postoperative incontinence between RT and no-RT groups.
Figure 3
Figure 3
Meta-analysis of revision surgery between RT and no-RT groups.
Figure 4
Figure 4
Meta-analysis of infection between RT and no-RT groups.
Figure 5
Figure 5
Meta-analysis of erosion between RT and no-RT groups.
Figure 6
Figure 6
Meta-analysis of explantation between RT and no-RT groups.
Figure 7
Figure 7
Meta-analysis of urethral atrophy between RT and no-RT groups.
Figure 8
Figure 8
Meta-analysis of mechanical failure between RT and no-RT groups.

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