A relative power table for nested matched case-control studies

D Pang, D Pang

Abstract

Objective: To calculate relative powers for nested case-control studies for different values of both relative risk and numbers of controls per case, given a fixed number of cases available for analysis.

Methods: Algebraic and numerical methods.

Results: In nested case-control studies, statistical power is a function of relative risk, rarity of exposure, number of case-control sets, and the number of controls per case.

Conclusion: The dictum that sufficient power will be obtained in a nested case-control study by selecting only four controls per case cannot be sustained. Appropriate numbers need to be calculated for specific studies.

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Source: PubMed

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