Prevalence of adult eczema, hay fever, and asthma, and associated risk factors: a population-based study in the northern Grassland of China

Xiaoyan Wang, Yan Zhuang, Yanlei Chen, Hongtian Wang, Xueyan Wang, Xiaoyan Wang, Yan Zhuang, Yanlei Chen, Hongtian Wang, Xueyan Wang

Abstract

Background: There has been research about the prevalence and risk factors of eczema, hay fever, and asthma in children, but little is known about these conditions in adults in China.

Objectives: To explore the prevalence of adult eczema/atopic dermatitis (AD) and its risk factors in northern China.

Methods: A cluster sampling randomized population-based survey was conducted using a face-to-face questionnaire combined with skin prick tests of ten common aeroallergens including nine pollen allergens and Dermatophagoides pteronyssinu (Dp) allergen. The questionnaire was designed by specialists and included questions on the prevalence of eczema, hay fever, and asthma, socioeconomic risk factors, family history of atopy and environmental exposures. The prevalence of eczema with asthma and/or hay fever (EAH) was applied as a proxy of AD in this study.

Results: Overall, 2096 subjects were enrolled and completed the study. The prevalence of eczema was 15.7% (95% CI 14.3-17.4), while the prevalence of hay fever and asthma were 20.6% (95% CI 18.9-22.4) and 6.5% (95% CI 5.5-7.6), respectively. In particular, the prevalence of EAH was 5.1% (95% CI 4.4-7.0). The prevalence of eczema and EAH was significantly associated with younger age, atopy family history, high education level, urbanization, and antibiotic overuse (P < 0.05, logistic regression). The sensitization rate was higher in EAH compared with eczema (48.2% vs 41.0%, P = 0.018), with weed pollen sensitization being the most common. Subjects with two or more concomitant allergic diseases had increased risk of eczema and EAH (P < 0.001). Allergen sensitization increased the risk of eczema and EAH (P < 0.001, both).

Conclusions: Adult eczema and EAH are prevalent in northern China under high pollen exposure. Socioeconomic and environmental factors affected the prevalence of adult AD in China. Dp had a particular impact on the prevalence of eczema/AD in the grassland region.

Keywords: Allergen sensitization; Atopic dermatitis; Eczema; Risk factors; Socioeconomic status.

Conflict of interest statement

The authors declare that no conflicts of interest exist.

Figures

Fig. 1
Fig. 1
The flow chart of the survey
Fig. 2
Fig. 2
Geographic locations of the study sites, including the Erenhot, Xilinhot, Duolun, Tongliao, Jarud, and Kailu areas of northern China
Fig. 3
Fig. 3
Distribution of eczema, hay fever, and asthma among the study cohort
Fig. 4
Fig. 4
Variation in eczema and EAH prevalence across different age groups and geographic regions
Fig. 5
Fig. 5
The sensitizati›on rate from SPT in eczema and EAH groups. a Demonstrates the sensitization rate in the eczema group, while b demonstrates the sensitization rate of the EAH group

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