Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study

David N Juurlink, Tara Gomes, Lorraine L Lipscombe, Peter C Austin, Janet E Hux, Muhammad M Mamdani, David N Juurlink, Tara Gomes, Lorraine L Lipscombe, Peter C Austin, Janet E Hux, Muhammad M Mamdani

Abstract

Objective: To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone.

Design: Retrospective cohort study.

Setting: Ontario, Canada.

Participants: Outpatients aged 66 years and older who were started on rosiglitazone or pioglitazone between 1 April 2002 and 31 March 2008.

Main outcome measure: Composite of death or hospital admission for either acute myocardial infarction or heart failure. In a secondary analysis, each outcome was also examined individually.

Results: 39 736 patients who started on either pioglitazone or rosiglitazone were identified. During the six year study period, the composite outcome was reached in 895 (5.3%) of patients taking pioglitazone and 1563 (6.9%) of patients taking rosiglitazone. After extensive adjustment for demographic and clinical factors and drug doses, pioglitazone treated patients had a lower risk of developing the primary outcome than did patients treated with rosiglitazone (adjusted hazard ratio 0.83, 95% confidence interval 0.76 to 0.90). Secondary analyses revealed a lower risk of death (adjusted hazard ratio 0.86, 0.75 to 0.98) and heart failure (0.77, 0.69 to 0.87) with pioglitazone but no significant difference in the risk of acute myocardial infarction (0.95, 0.81 to 1.11). One additional composite outcome would be predicted to occur annually for every 93 patients treated with rosiglitazone rather than pioglitazone.

Conclusions: Among older patients with diabetes, pioglitazone is associated with a significantly lower risk of heart failure and death than is rosiglitazone. Given that rosiglitazone lacks a distinct clinical advantage over pioglitazone, continued use of rosiglitazone may not be justified.

Conflict of interest statement

Competing interests: None declared.

Figures

https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4787351/bin/juud640854.f1_default.jpg
Fig 1 Survival curves for primary outcome (composite of death or hospital admission for acute myocardial infarction or heart failure) from start of treatment with pioglitazone or rosiglitazone, adjusted for factors outlined in web appendix
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4787351/bin/juud640854.f2_default.jpg
Fig 2 Survival curves for hospital admission for heart failure from start of treatment with pioglitazone or rosiglitazone, adjusted for factors outlined in web appendix
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4787351/bin/juud640854.f3_default.jpg
Fig 3 Survival curves for hospital admission for acute myocardial infarction from start of treatment with pioglitazone or rosiglitazone, adjusted for factors outlined in web appendix
https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4787351/bin/juud640854.f4_default.jpg
Fig 4 Survival curves for death from any cause from start of treatment with pioglitazone or rosiglitazone, adjusted for factors outlined in web appendix

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