Cereal-Based Snack Bar with Added Plant Stanol Ester (Benecol®) Consumed between Meals Lowers Serum Total and LDL Cholesterol Effectively in Mildly to Moderately Hypercholesterolemic Subjects

Essi Sarkkinen, Mari Lyyra, Sakari Nieminen, Päivi Kuusisto, Ingmar Wester, Essi Sarkkinen, Mari Lyyra, Sakari Nieminen, Päivi Kuusisto, Ingmar Wester

Abstract

The cholesterol-lowering effect of foods with added plant sterols or stanols consumed as snacks might be compromised. The purpose of this study was to confirm the cholesterol-lowering efficacy of a specially formulated cereal-based snack bar with added plant stanol ester (1.6 g plant stanols/day) when consumed between meals twice a day. In a double-blind, placebo-controlled, 4-week parallel-design study, 71 mildly to moderately hypercholesterolemic subjects were randomized into one of two groups, stanol or placebo group. Subjects were advised to replace their ordinary snacks with test products in an isocaloric manner and otherwise keep their habitual diet unchanged. The study showed that a snack bar product with added plant stanol ester lowered LDL and non-HDL cholesterol by 8.6% and 9.2% (mean%-change), respectively, as compared to the placebo product. The change in LDL cholesterol was statistically significantly different (P = 0.001) between the groups while the change in HDL cholesterol or triglycerides did not differ between the groups. In conclusion, the cereal-based snack bar with added plant stanol ester ingested without a meal reduced LDL cholesterol significantly without affecting HDL cholesterol or triglyceride concentrations in mildly hypercholesterolemic men and women. The study is registered as NCT03284918.

Figures

Figure 1
Figure 1
Percentage changes in serum total (TC) and lipoprotein lipids (LDL cholesterol, HDL cholesterol, and non-HDL cholesterol) during 4-week intervention in Placebo and Stanol group (mean ± SD). ∗Statistically significant difference between the groups P ≤ 0.001.

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Source: PubMed

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