Evaluation of Dentifrice Containing Nano-hydroxyapatite for Dentinal Hypersensitivity: A Randomized Controlled Trial

Nithin Manchery Gopinath, Joseph John, N Nagappan, S Prabhu, E Senthil Kumar, Nithin Manchery Gopinath, Joseph John, N Nagappan, S Prabhu, E Senthil Kumar

Abstract

Background: This randomized, double-blind, parallel arm study was carried out to evaluate and compare the effectiveness between nano-hydroxyapatite (HAP) and a benchmark dentifrice in reducing dentin hypersensitivity.

Materials and methods: About 36 patients were selected, randomly divided into two groups and was evaluated clinically using three different stimuli, i.e., tactile, air blast, and cold water test. The patient's responses to various stimuli were recorded using a visual analog scale at baseline and after 4 weeks.

Results: Statistical analysis was done using unpaired and paired t-tests. It was seen that patients treated in both groups showed significant reductions scores across all sensitivity measures at the end of 4 weeks.

Conclusion: The HAP containing toothpaste was effective in reducing dentin hypersensitivity with pre-existing benchmark toothpaste tested and hence can be advocated in the management of hypersensitivity.

Keywords: Clinical trials; NovaMin; dentinal hypersensitivity; hypersensitivity; nano-hydroxyapatite.

Conflict of interest statement

Conflicts of Interest: None

Figures

Figure 1
Figure 1
Distribution of subjects based on age and gender.

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