Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women
Fatima Nayeem, Karl E Anderson, Manubai Nagamani, James J Grady, Lee-Jane W Lu, Fatima Nayeem, Karl E Anderson, Manubai Nagamani, James J Grady, Lee-Jane W Lu
Abstract
C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R(2)=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.
Trial registration: ClinicalTrials.gov NCT00204477.
Conflict of interest statement
Disclosures: All authors have no financial conflict of interest.
Source: PubMed