Proteome-wide anti-hepatitis C virus (HCV) and anti-HIV antibody profiling for predicting and monitoring the response to HCV therapy in HIV-coinfected patients
Peter D Burbelo, Joseph A Kovacs, Kathryn H Ching, Alexandra T Issa, Michael J Iadarola, Alison A Murphy, Joerg F Schlaak, Henry Masur, Michael A Polis, Shyam Kottilil, Peter D Burbelo, Joseph A Kovacs, Kathryn H Ching, Alexandra T Issa, Michael J Iadarola, Alison A Murphy, Joerg F Schlaak, Henry Masur, Michael A Polis, Shyam Kottilil
Abstract
We quantified antibody responses to the hepatitis C virus (HCV) proteome that are associated with sustained virologic response (SVR) in human immunodeficiency virus (HIV)/HCV-coinfected patients treated with pegylated interferon and ribavirin. Analysis of pre- and posttreatment samples revealed significant decreases in the combined anti-core, anti-E1, and anti-NS4 HCV antibody titers in those with SVRs but not in those who experienced relapse or who did not respond. Furthermore, anti-HIV p24 antibody titers inversely correlated with treatment response. These results suggest that profiling anti-HCV antibody is useful for monitoring HCV therapy, especially in discriminating between those who experience relapse and those who have SVRs at 48 weeks.
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Source: PubMed