Feasibility, benefit and risk of systematic intraoperative cholangiogram in patients undergoing emergency cholecystectomy

Pouya Iranmanesh, Olivier Tobler, Sandra De Sousa, Axel Andres, Jean-Louis Frossard, Philippe Morel, Christian Toso, Pouya Iranmanesh, Olivier Tobler, Sandra De Sousa, Axel Andres, Jean-Louis Frossard, Philippe Morel, Christian Toso

Abstract

Background: The role of intraoperative cholangiogram (IOC) during cholecystectomy is debated. The aim of the present study was to evaluate the feasibility, benefit and risk of performing systematic IOC in patients undergoing cholecystectomy for acute gallstone-related disease.

Methods: Between July 2013 and January 2015, all patients admitted for an acute gallstone-related condition and undergoing same-hospital-stay cholecystectomy were prospectively followed. IOC was systematically attempted and predictors of IOC failure were analyzed.

Results: Among the 581 enrolled patients, IOC was deliberately not performed in 3 cases. IOC was successful in 509/578 patients (88.1%). The main predictors of IOC failure were age, body mass index, male gender and associated acute cholecystitis. Thirty-two patients with suspected common bile duct stone on IOC underwent 38 unnecessary negative postoperative common bile duct investigations (32/509, 6.3%). There was one IOC-related adverse outcome (mild pancreatitis, 1/578, 0.2%).

Conclusions: IOC can be successfully and safely performed in the majority of patients undergoing cholecystectomy for acute gallstone-related disease. Although its positive predictive value is suboptimal and results in a number of unnecessary postoperative common bile duct investigations, IOC accurately rules out common bile duct stones in patients with acute gallstone-related conditions.

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1. Flow-chart.
Fig 1. Flow-chart.
IOC = intraoperative cholangiogram.

References

    1. Friedman GD. Natural history of asymptomatic and symptomatic gallstones. Am J Surg. 1993;165: 399–404.
    1. Shaheen NJ, Hansen RA, Morgan DR, Gangarosa LM, Ringel Y, Thiny MT, et al. The burden of gastrointestinal and liver diseases. Am J Gastroenterol. 2006; 101: 2128–2138. doi:
    1. Lau H, Lo CY, Patil NG, Yuen WK. Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a meta-analysis. Surg Endosc. 2006; 20: 82–87. doi:
    1. Peng WK, Sheikh Z, Nixon SJ, Paterson-Brown S. Role of laparoscopic cholecystectomy in the early management of acute gallbladder disease. Br J Surg. 2005; 92: 586–591. doi:
    1. da Costa DW, Bouwense SA, Schepers NJ, Bessselink MG, van Santvoort HC, van Brunschot S, et al. Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial. Lancet. 2015; 386: 1261–1268. doi:
    1. Sajid MS, Leaver C, Haider Z, Worthington T, Karanjia N, Singh KK. Routine on-table cholangiography during cholecystectomy: a systematic review. Ann R Coll Surg Engl. 2012; 94: 375–380. doi:
    1. Ausania F, Holmes LR, Ausania F, Iype S, Ricci P, White SA. Intraoperative cholangiography in the laparoscopic cholecystectomy era: why are we still debating? Surg Endosc. 2010; 26: 1193–1200.
    1. Alvarez FA, de Santibañes M, Palavecino M, Sánchez Clariá R, Mazza O, Arbues G, et al. Impact of routine intraoperative cholangiography during laparoscopic cholecystectomy on bile duct injury. Br J Surg. 2014; 101: 677–684. doi:
    1. Flum DR, Dellinger EP, Cheadle A, Chan L, Koepsell T. Intraoperative cholangiography and risk of common bile duct injury during cholecystectomy. JAMA. 2003; 289: 1639–1644. doi:
    1. Ragulin-Coyne E, Witkowski ER, Chau Z, Ng SC, Santry HP, Callery MP, et al. Is routine intraoperative cholangiogram necessary in the twenty-first century? A national view. J Gastrointest Surg. 2013; 17: 434–442. doi:
    1. Ding GQ, Cai W, Qin MF. Is intraoperative cholangiography necessary during laparoscopic cholecystectomy for cholelithiasis? World J Gastroenterol. 2015; 21: 2147–2151. doi:
    1. ASGE Standards of Practice Committee., Maple JT, Ben-Menachem T, Anderson MA, Appalaneni V, Banerjee S, et al. The role of endoscopy in the evaluation of suspected choledocholithiasis. Gastrointest Endosc. 2010; 71: 1–9. doi:
    1. Sarli L, Costi R, Gobbi S, Iusco D, Sgobba G, Roncoroni L. Scoring system to predict asymptomatic choledocholithiasis before laparoscopic cholecystectomy. A matched case-control study. Surg Endosc. 2003;17: 1396–1403. doi:
    1. Sun XD, Cai XY, Li JD, Cai XJ, Mu YP, Wu JM. Prospective study of scoring system in selective intraoperative cholangiography during laparoscopic cholecystectomy. World J Gastroenterol. 2003; 9: 865–867. doi:
    1. Törnqvist B, Strömberg C, Akre O, Enochsson L, Nilsson M. Selective intraoperative cholangiography and risk of bile duct injury during cholecystectomy. Br J Surg. 2015; 102: 952–958. doi:
    1. Halawani HM, Tamim H, Khalifeh F, Mailhac A, Jamali FR. Impact of intraoperative cholangiography on postoperative morbidity and readmission: analysis of the NSQIP database. Surg Endosc. 2016; 30: 5395–5403. doi:
    1. Iranmanesh P, Frossard JL, Mugnier-Konrad B, Morel P, Majno P, Nguyen-Tang T, et al. Initial cholecystectomy vs sequential common duct endoscopic assessment and subsequent cholecystectomy for suspected gallstone migration: a randomized clinical trial. JAMA. 2014; 312: 137–144. doi:
    1. Takada T, Strasberg SM, Solomkin JS, Pitt HA, Gomi H, Yoshida M, et al. TG13: Updated Tokyo Guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013; 20: 1–7. doi:
    1. Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013; 62: 102–111. doi:
    1. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004; 240: 205–213. doi:
    1. Kissebah AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev. 1994; 74: 761–811. doi:
    1. Frossard JL, Hadengue A, Amouyal G, Choury A, Marty O, Giostra E, et al. Choledocholithiasis: a prospective study of spontaneous common bile duct stone migration. Gastrointest Endosc. 2000; 51: 175–179.
    1. Karthikesalingam A, Markar SR, Weerakkody R, Walsh SR, Carroll N, Praseedom RK. Radiation exposure during laparoscopic cholecystectomy with routine intraoperative cholangiography. Surg Endosc. 2009; 23: 1845–1848. doi:
    1. Kumar A, Kumar U, Munghate A, Bawa A. Role of routine intraoperative cholangiography during laparoscopic cholecystectomy. Surg Endosc. 2015; 29: 2837–2840. doi:
    1. Yaghoobi M, Meeralam Y, Al-Shammari K. Diagnostic accuracy of EUS compared with MRCP in detecting choledocholithiasis: a meta-analysis of diagnostic test accuracy of head-to-head studies. Gastrointest Endosc. 2017. June 20 pii: S0016-5107(17)32032-1. doi: [Epub ahead of print].
    1. Verma D, Kapadia A, Eisen GM, Adler DG. EUS vs MRCP for detection of choledocholithiasis. Gastrointest Endosc. 2006; 64: 248–254. doi:
    1. De Castro VL, Moura EG, Chaves DM, Bernardo WM, Matuguma SE, Artifon EL. Endoscopic ultrasound versus magnetic resonance cholangiopancreatography in suspected choledocholithiasis: A systematic review. Endosc Ultrasound. 2016; 5: 118–128. doi:

Source: PubMed

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