Algorithm for rational use of Film Array Pneumonia Panel in bacterial coinfections of critically ill ventilated COVID-19 patients

Emmanuel Novy, Antoine Goury, Carine Thivilier, Thomas Guillard, Corentine Alauzet, Emmanuel Novy, Antoine Goury, Carine Thivilier, Thomas Guillard, Corentine Alauzet

Abstract

The FilmArray Pneumonia Panel has proven to be an effective tool for rapid detection of main respiratory pathogens. However, its rational use needs appropriate knowledge and formation regarding its indication and interpretation. Herein, we provide some advices to help with success of its daily routine use, particularly in critically ill ventilated COVID-19 patients. Clinical Trial registration number: NCT04453540.

Keywords: Antimicrobial stewardship; Bacterial coinfection; Covid-19; Critically ill; Molecular diagnosis; Pneumonia.

Copyright © 2021 Elsevier Inc. All rights reserved.

Figures

Fig. 1
Fig. 1
Clinical algorithm for initiating antibiotics using FAPP in bacterial coinfection of critically ill COVID-19 patients. IMV, invasive mechanical ventilation; BAL, bronchoalveolar lavage; FAPP, FilmArray® Pneumonia Panel; ATB, antibiotics; GNB, Gram-negative bacilli. a Endotracheal aspirate samples could be used but need cautious interpretation regarding the risk of over-diagnosis due to tracheobronchial colonization; b Septic shock (according to SEPSIS-3) or severe ARDS (according to Berlin criteria).

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Source: PubMed

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