Prevalence and short-term changes of cognitive dysfunction in young ischaemic stroke patients

D Pinter, C Enzinger, T Gattringer, S Eppinger, K Niederkorn, S Horner, S Fandler, M Kneihsl, K Krenn, G Bachmaier, F Fazekas, D Pinter, C Enzinger, T Gattringer, S Eppinger, K Niederkorn, S Horner, S Fandler, M Kneihsl, K Krenn, G Bachmaier, F Fazekas

Abstract

Background and purpose: Information on the prevalence and course of post-stroke cognitive impairment in young stroke patients is limited. The aim was to assess a consecutive sample of acute young ischaemic stroke patients (18-55 years) for the presence and development of neuropsychological deficits.

Methods: Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first 3 weeks after hospital admission (median assessment at day 6) and at a 3 months' follow-up (FU). Cognitive dysfunction was defined in comparison to age-standardized published norms.

Results: At baseline (N = 114), deficits were highly prevalent in processing speed (56.0%), flexibility/executive function (49.5%), attention (46.4%) and general cognitive function (42.1%). These frequencies were comparable for those with FU assessment (N = 87). In most domains, cognitive performance improved within 3 months, except for word fluency. However, in about one-third of patients, cognitive deficits (as defined by 1.5 standard deviations below the standardized mean) were still present 3 months after stroke. At FU, 44.0% were impaired in the domain flexibility/executive function, 35.0% in processing speed and 30.0% in attention.

Conclusions: The high prevalence of cognitive deficits in acute young patients with ischaemic stroke highlights the importance of early post-stroke cognitive assessment to capture a patient's dysfunction in a comprehensive manner and to offer adequate rehabilitation. The role of factors which promote neuropsychological deficits needs further exploration.

Keywords: acute; changes; cognition; processing speed; stroke; young.

Conflict of interest statement

The authors declare no financial or other conflicts of interest.

© 2018 The Authors European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

Figures

Figure 1
Figure 1
Prevalence changes of patients with cognitive impairment (1.5 standard deviations below standardized mean). *P < 0.001. At FU, scores of the cognitive subtests were available for N = 86 (CTMT‐2), N = 85 (CTMT‐5) and N = 80 (RWT, HADS). [Color figure can be viewed at wileyonlinelibrary.com]

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