Characteristics of the delayed respiratory syncytial virus epidemic, 2020/2021, Rhône Loire, France

Jean-Sebastien Casalegno, Dominique Ploin, Aymeric Cantais, Elsa Masson, Emilie Bard, Martine Valette, Remi Fanget, Sandrine Couray Targe, Anne-Florence Myar-Dury, Muriel Doret-Dion, Mona Massoud, Gregory Queromes, Philippe Vanhems, Olivier Claris, Marine Butin, Sylvie Pillet, Florence Ader, Sylvie Bin, Alexandre Gaymard, Bruno Lina, Florence Morfin, VRS study group in Lyon, Etienne Javouhey, Yves Gillet, Antoine Ouziel, Jean-Claude Tardy, Pascal Gaucherand, Luc Panetta, Jerome Massardier, Stephanie Polazzi, Antoine Duclos, Mehdi Benchaib, Regine Cartier, Marine Jourdain, Michelle Ottmann, Rolf Kramer, Sylvie Fiorini, Nathalie Rivat, Yahia Mekki, Julie Fort-Jacquier, Maud-Catherine Barral, Vey Noelie, Julie Haesebaert, Come Horvat, Leo Vidoni, Jean-Marc Reynes, Jean-Francois Eleouet, Laurence Josset, Matthieu Receveur, Jean-Sebastien Casalegno, Dominique Ploin, Aymeric Cantais, Elsa Masson, Emilie Bard, Martine Valette, Remi Fanget, Sandrine Couray Targe, Anne-Florence Myar-Dury, Muriel Doret-Dion, Mona Massoud, Gregory Queromes, Philippe Vanhems, Olivier Claris, Marine Butin, Sylvie Pillet, Florence Ader, Sylvie Bin, Alexandre Gaymard, Bruno Lina, Florence Morfin, VRS study group in Lyon, Etienne Javouhey, Yves Gillet, Antoine Ouziel, Jean-Claude Tardy, Pascal Gaucherand, Luc Panetta, Jerome Massardier, Stephanie Polazzi, Antoine Duclos, Mehdi Benchaib, Regine Cartier, Marine Jourdain, Michelle Ottmann, Rolf Kramer, Sylvie Fiorini, Nathalie Rivat, Yahia Mekki, Julie Fort-Jacquier, Maud-Catherine Barral, Vey Noelie, Julie Haesebaert, Come Horvat, Leo Vidoni, Jean-Marc Reynes, Jean-Francois Eleouet, Laurence Josset, Matthieu Receveur

Abstract

The Rhône-Loire metropolitan areas' 2020/21 respiratory syncytial virus (RSV) epidemic was delayed following the implementation of non-pharmaceutical interventions (NPI), compared with previous seasons. Very severe lower respiratory tract infection incidence among infants ≤ 3 months decreased twofold, the proportion of cases among children aged > 3 months to 5 years increased, and cases among adults > 65 years were markedly reduced. NPI appeared to reduce the RSV burden among at-risk groups, and should be promoted to minimise impact of future RSV outbreaks.

Trial registration: ClinicalTrials.gov NCT04944160.

Keywords: COVID-19; RSV; SARI; SARS-CoV-2; bronchiolitis; disease burden; non-pharmacological interventions; pharmacological interventions.

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Number of laboratory-confirmed respiratory syncytial virus cases by week, university hospitals of Lyon and Saint-Etienne, France, epidemiological seasons 2018/19−2020/21
Figure 2
Figure 2
Age pyramid of respiratory syncytial virus cases by epidemiological season, university hospitals of Lyon and Saint-Etienne, France, epidemiological seasons 2018/19−2020/21a

References

    1. Cowling BJ, Ali ST, Ng TWY, Tsang TK, Li JCM, Fong MW, et al. Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study. Lancet Public Health. 2020;5(5):e279-88. 10.1016/S2468-2667(20)30090-6
    1. Foley DA, Yeoh DK, Minney-Smith CA, Martin AC, Mace AO, Sikazwe CT, et al. The Interseasonal Resurgence of Respiratory Syncytial Virus in Australian Children Following the Reduction of Coronavirus Disease 2019-Related Public Health Measures. Clin Infect Dis. 2021;ciaa1906. / 10.1093/cid/ciaa1906 PMID:33594407
    1. National Institute for Communicable Diseases (NICD). Weekly Respiratory Pathogens Surveillance Report 2021. Johannesburg: NICD; 2021. Available from:
    1. Casalegno JS, Javouhey E, Ploin D, Valette M, Fanget R, Couray-Targe S, et al. Delayed Start of the Respiratory Syncytial Virus Epidemic at the End of the 20/21 Northern Hemisphere Winter Season, Lyon, France. MedRxiv 2021.03.12.21253446. 2021. Available from:
    1. Delestrain C, Danis K, Hau I, Billard MN, Kragten L, Cohen R, et al. Impact of COVID-19 social distancing on viral infection in France: a delayed outbreak of RSV. Authorea. 2021 Available from:
    1. Sciensano. Weekly bulletin respiratory infections, Season 2020-2021. Brussels: Sciensano; 2021. Available from:
    1. Gaymard A, Bouscambert-Duchamp M, Pichon M, Frobert E, Vallee J, Lina B, et al. Genetic characterization of respiratory syncytial virus highlights a new BA genotype and emergence of the ON1 genotype in Lyon, France, between 2010 and 2014. J Clin Virol. 2018;102:12-8. 10.1016/j.jcv.2018.02.004
    1. Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: a systematic review and meta-analysis. J Infect. 2020;81(2):266-75. 10.1016/j.jinf.2020.05.046
    1. Modjarrad K, Giersing B, Kaslow DC, Smith PG, Moorthy VS; WHO RSV Vaccine Consultation Expert Group. WHO consultation on Respiratory Syncytial Virus Vaccine Development Report from a World Health Organization Meeting held on 23-24 March 2015. Vaccine. 2016;34(2):190-7. / 10.1016/j.vaccine.2015.05.093 PMID:26100926
    1. Kramer R, Duclos A, Lina B, Casalegno JS, VRS study group in Lyon . Cost and burden of RSV related hospitalisation from 2012 to 2017 in the first year of life in Lyon, France. Vaccine. 2018;36(45):6591-3. 10.1016/j.vaccine.2018.09.029
    1. Santé publique France. Bulletin épidémiologique bronchiolite, Saison 2020-2021. Saint-Maurice : Santé publique France, 2021. Available from:
    1. Trenholme A, Webb R, Lawrence S, Arrol S, Taylor S, Ameratunga S, et al. COVID-19 and Infant Hospitalizations for Seasonal Respiratory Virus Infections, New Zealand, 2020. Emerg Infect Dis. 2021;27(2):641-3. 10.3201/eid2702.204041
    1. Hall CB, Simőes EA, Anderson LJ. Clinical and epidemiologic features of respiratory syncytial virus. Curr Top Microbiol Immunol. 2013;372:39-57. 10.1007/978-3-642-38919-1_2
    1. Li Y, Johnson EK, Shi T, Campbell H, Chaves SS, Commaille-Chapus C, et al. National burden estimates of hospitalisations for acute lower respiratory infections due to respiratory syncytial virus in young children in 2019 among 58 countries: a modelling study. Lancet Respir Med. 2021;9(2):175-85. 10.1016/S2213-2600(20)30322-2
    1. Baker RE, Mahmud AS, Wagner CE, Yang W, Pitzer VE, Viboud C, et al. Epidemic dynamics of respiratory syncytial virus in current and future climates. Nat Commun. 2019;10(1):5512. 10.1038/s41467-019-13562-y
    1. Baker RE, Park SW, Yang W, Vecchi GA, Metcalf CJE, Grenfell BT. The impact of COVID-19 nonpharmaceutical interventions on the future dynamics of endemic infections. Proc Natl Acad Sci USA. 2020;117(48):30547-53. 10.1073/pnas.2013182117

Source: PubMed

Sponsoren und Mitarbeiter

Krankheiten

Drogeninterventionen

3
Abonnieren