Obesity and outpatient rehabilitation using mobile technologies: the potential mHealth approach

Gianluca Castelnuovo, Gian Mauro Manzoni, Giada Pietrabissa, Stefania Corti, Emanuele Maria Giusti, Enrico Molinari, Susan Simpson, Gianluca Castelnuovo, Gian Mauro Manzoni, Giada Pietrabissa, Stefania Corti, Emanuele Maria Giusti, Enrico Molinari, Susan Simpson

Abstract

Obesity is currently an important public health problem of epidemic proportions (globesity). Inpatient rehabilitation interventions that aim at improving weight-loss, reducing obesity-related complications and changing dysfunctional behaviors, should ideally be carried out in a multidisciplinary context with a clinical team composed of psychologists, dieticians, psychiatrists, endocrinologists, nutritionists, physiotherapists, etc. Long-term outpatient multidisciplinary treatments are likely to constitute an essential aspect of rehabilitation. Internet-based technologies can improve long-term obesity rehabilitation within a collaborative approach by enhancing the steps specified by psychological and medical treatment protocols. These outcomes may be augmented further by the mHealth approach, through creating new treatment delivery methods to increase compliance and engagement. mHealth (m-health, mobile health) can be defined as the practice of medicine and public health, supported by mobile communication devices for health services and information. mHealth applications which can be implemented in weight loss protocols and obesity rehabilitation are discussed, taking into account future research directions in this promising area.

Keywords: clinical psychology; health psychology; mHealth; obesity; psychotherapy; rehabilitation; telecare; telemedicine.

References

    1. American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders 4th Edn (Washington, DC: American Psychiatric Association)
    1. Bacigalupo R., Cudd P., Littlewood C., Bissell P., Hawley M. S, Buckley Woods H. (2013). Interventions employing mobile technology for overweight and obesity: an early systematic review of randomized controlled trials. Obes. Rev. 14 279–291 10.1111/obr.12006
    1. Berkowitz R. I., Fabricatore A. N. (2011). Obesity, psychiatric status, and psychiatric medications. Psychiatr. Clin. North Am. 34 747–764 10.1016/j.psc.2011.08.007
    1. Burke L. E., Styn M. A., Sereika S. M., Conroy M. B., Ye L., Glanz K., et al. (2012). Using mHealth technology to enhance self-monitoring for weight loss: a randomized trial. Am. J. Prev. Med. 43 20–26 10.1016/j.amepre.2012.03.016
    1. Cafazzo J. A., Casselman M., Hamming N., Katzman D. K., Palmert M. R. (2012). Design of an mHealth app for the self-management of adolescent type 1 diabetes: a pilot study. J. Med. Internet Res. 14:e70. 10.2196/jmir.2058
    1. Capodaglio P., Capodaglio E. M., Precilios H., Vismara L., Tacchini E., Finozzi E., et al. (2011). Obesity and work: an emerging problem. G. Ital. Med. Lav. Ergon. 33 47–54
    1. Capodaglio P., Castelnuovo G., Brunani A., Vismara L., Villa V., Capodaglio E. M. (2010). Functional limitations and occupational issues in obesity: a review. Int. J. Occup. Saf. Ergon. 16 507–523
    1. Capodaglio P., Cimolin V., Tacchini E., Precilios H., Brunani A. (2013a). Effectiveness of in-patient rehabilitation in obesity-related orthopedic conditions. J. Endocrinol. Invest. 36 628–631 10.3275/8897
    1. Capodaglio P., Lafortuna C., Petroni M. L., Salvadori A., Gondoni L., Castelnuovo G., et al. (2013b). Rationale for hospital-based rehabilitation in obesity with comorbidities. Eur. J. Phys. Rehabil. Med. 49 399–417
    1. Capodaglio P., Liuzzi A. (2013). Obesity: a disabling disease or a condition favoring disability? dEur. J. Phys. Rehabil. Med. 49 395–398
    1. Castelnuovo G. (2007). Move the healthcare where it really needs: TECNOB project to improve outpatient obesity treatment. (E-letter in response to Wister, Loewen, Kennedy-Symonds, McGowan, McCoy, Singer, “One-year follow-up of a therapeutic lifestyle intervention targeting cardiovascular disease risk.”) CMAJ 177 859–865 10.1503/cmaj.061059
    1. Castelnuovo G. (2010a). Empirically supported treatments in psychotherapy: towards an evidence-based or evidence-biased psychology in clinical settings? Front. Psychol. 1:27. 10.3389/fpsyg.2010.00027
    1. Castelnuovo G. (2010b). No medicine without psychology: the key role of psychological contribution in clinical settings. Front. Psychol. 1:4. 10.3389/fpsyg.2010.00004
    1. Castelnuovo G., Gaggioli A., Mantovani F., Riva G. (2003). From psychotherapy to e-therapy: the integration of traditional techniques and new communication tools in clinical settings. Cyberpsychol. Behav. 6 375–382 10.1089/109493103322278754
    1. Castelnuovo G., Manzoni G. M., Corti S., Cuzziol P., Villa V., Molinari E. (2011a). “Clinical psychology and medicine for the treatment of obesity in out-patient settings: the TECNOB project,” in Telemedicine Techniques and Applications eds Graschew G., Rakowsky S. (Rijeka: InTech; ) 257–268
    1. Castelnuovo G., Manzoni G. M., Cuzziol P., Cesa G. L., Corti S., Tuzzi C., et al. (2011b). TECNOB study: ad interim results of a randomized controlled trial of a multidisciplinary telecare intervention for obese patients with type-2 diabetes. Clin. Pract. Epidemiol. Ment. Health 7 44–50 10.2174/1745017901107010044
    1. Castelnuovo G., Manzoni G. M., Villa V., Cesa G. L., Molinari E. (2011c). Brief strategic therapy vs cognitive behavioral therapy for the inpatient and telephone-based outpatient treatment of binge eating disorder: the STRATOB randomized controlled clinical trial. Clin. Pract. Epidemiol. Ment. Health 7 29–37 10.2174/1745017901107010029
    1. Castelnuovo G., Manzoni G. M., Villa V., Cesa G. L., Pietrabissa G., Molinari E. (2011d). The STRATOB study: design of a randomized controlled clinical trial of Cognitive Behavioral Therapy and Brief Strategic Therapy with telecare in patients with obesity and binge-eating disorder referred to residential nutritional rehabilitation. Trials 12:114. 10.1186/1745-6215-12-114
    1. Castelnuovo G., Manzoni G. M., Cuzziol P., Cesa G. L., Tuzzi C., Villa V., et al. (2010). TECNOB: study design of a randomized controlled trial of a multidisciplinary telecare intervention for obese patients with type-2 diabetes. BMC Public Health 10:204. 10.1186/1471-2458-10-204
    1. Castelnuovo G., Simpson S. (2011). Ebesity – e-health for obesity – new technologies for the treatment of obesity in clinical psychology and medicine. Clin. Pract. Epidemiol. Ment. Health 7 5–8 10.2174/1745017901107010005
    1. Chomutare T., Fernandez-Luque L., Arsand E., Hartvigsen G. (2011). Features of mobile diabetes applications: review of the literature and analysis of current applications compared against evidence-based guidelines. J. Med. Internet Res. 13:e65. 10.2196/jmir.1874
    1. Cipresso P., Serino S., Villani D., Repetto C., Selitti L., Albani G., et al. (2012). Is your phone so smart to affect your states? An exploratory study based on psychophysiological measures. Neurocomputing 84 23–30 10.1016/j.neucom.2011.12.027
    1. Cohen G. M., Irby M. B., Boles K., Jordan C., Skelton J. A. (2012). Telemedicine and Pediatric Obesity Treatment: review of the literature and lessons learned. Clin. Obes. 2 103–111 10.1111/j.1758-8111.2012.00050.x
    1. Davin S. A., Taylor N. M. (2009). Comprehensive review of obesity and psychological considerations for treatment. Psychol. Health Med. 14 716–725 10.1080/13548500903431501
    1. Dombrowski S. U., Avenell A., Sniehott F. F. (2011). Behavioral interventions for obese adults with additional risk factors for morbidity: systematic review of effects on behavior, weight and disease risk factors. Obes. Facts 3 377–396 10.1159/000323076
    1. Dombrowski S. U., Sniehotta F. F., Avenell A., Johnston M., MacLennan G., Araújo-Soares V. (2012). Identifying active ingredients in complex behavioral interventions for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: a systematic review. Health Psychol. Rev. 6 7–32 10.1080/17437199.2010.513298
    1. Ekeland A. G., Bowes A., Flottorp S. (2010). Effectiveness of telemedicine: a systematic review of reviews. Int. J. Med. Inform. 79 736–771 10.1016/j.ijmedinf.2010.08.006
    1. Ekeland A. G., Bowes A., Flottorp S. (2011). Methodologies for assessing telemedicine: a systematic review of reviews. Int. J. Med. Inform. 81 1–11 10.1016/j.ijmedinf.2011.10.009
    1. Eysenbach G. (2001). What is e-health? J. Med. Internet Res. 3:e20. 10.2196/jmir.3.2.e20
    1. Eysenbach G. (2011). Can tweets predict citations? Metrics of social impact based on Twitter and correlation with traditional metrics of scientific impact. J. Med. Internet Res. 13:e123. 10.2196/jmir.2012
    1. Faulconbridge L. F., Bechtel C. F. (2014). Depression and Disordered Eating in the Obese Person. Curr. Obes. Rep. 3 127–136 10.1007/s13679-013-0080-9
    1. Fiordelli M., Diviani N., Schulz P. J. (2013). Mapping mHealth research: a decade of evolution. J. Med. Internet Res. 15 e95 10.2196/jmir.2430
    1. Flegal K. M., Graubard B. I., Williamson D. F., Gail M. H. (2005). Excess deaths associated with underweight, overweight, and obesity. JAMA 293 1861–1867 10.1001/jama.293.15.1861
    1. Foster G. D., Makris A. P., Bailer B. A. (2005). Behavioral treatment of obesity. Am. J. Clin. Nutr. 82(Suppl. 1) 230S–235S
    1. Foster G. D., Wadden T. A., Vogt R. A., Brewer G. (1997). What is a reasonable weight loss? Patients’ expectations and evaluations of obesity treatment outcomes. J. Consult. Clin. Psychol. 65 79–85 10.1037/0022-006X.65.1.79
    1. Gearhardt A., Roberts M., Ashe M. (2013). If sugar is addictive...what does it mean for the law? J. Law Med. Ethics 41(Suppl. 1) 46–49. 10.1111/jlme.12038
    1. Gearhardt A. N., Brownell K. D. (2013). Can food and addiction change the game? Biol. Psychiatry 73 802–803 10.1016/j.biopsych.2012.07.024
    1. Gearhardt A. N., Corbin W. R. (2011). The role of food addiction in clinical research. Curr. Pharm. Des. 17 1140–1142 10.2174/138161211795656800
    1. Gearhardt A. N., Corbin W. R., Brownell K. D. (2009). Food addiction: an examination of the diagnostic criteria for dependence. J. Addict. Med. 3 1–7 10.1097/ADM.0b013e318193c993
    1. Gearhardt A. N., Davis C., Kuschner R., Brownell K. D. (2011a). The addiction potential of hyperpalatable foods. Curr. Drug Abuse Rev. 4 140–145 10.2174/1874473711104030140
    1. Gearhardt A. N., Grilo C. M., DiLeone R. J., Brownell K. D., Potenza M. N. (2011b). Can food be addictive? Public health and policy implications. Addiction 106 1208–1212 10.1111/j.1360-0443.2010.03301.x
    1. Gearhardt A. N., White M. A., Potenza M. N. (2011c). Binge eating disorder and food addiction. Curr. Drug Abuse Rev. 4 201–207 10.2174/1874473711104030201
    1. Gearhardt A. N., Yokum S., Orr P. T., Stice E., Corbin W. R., Brownell K. D. (2011d). Neural correlates of food addiction. Arch. Gen. Psychiatry 68 808–816 10.1001/archgenpsychiatry.2011.32
    1. Gearhardt A. N., White M. A., Masheb R. M., Morgan P. T., Crosby R. D., Grilo C. M. (2012). An examination of the food addiction construct in obese patients with binge eating disorder. Int. J. Eat. Disord. 45 657–663 10.1002/eat.20957
    1. Graffigna G., Barello S., Riva G. (2013a). Technologies for patient engagement. Health Aff. (Millwood) 32 1172 10.1377/hlthaff.2013.0279
    1. Graffigna G., Barello S., Wiederhold B. K., Bosio A. C., Riva G. (2013b). Positive technology as a driver for health engagement. Stud. Health Technol. Inform. 191 9–17 10.3233/978-1-61499-282-0-9
    1. Gutierrez-Fisac J. L., Angel Royo-Bordonada M., Rodriguez-Artalejo F. (2006). Health-risks associated with Western diet and sedentariness: the obesity epidemia. Gac. Sanit. 20(Suppl. 1) 48–54 10.1157/13086026
    1. Hebden L., Balestracci K., McGeechan K., Denney-Wilson E., Harris M., Bauman A., et al. (2013). ‘TXT2BFiT’ a mobile phone-based healthy lifestyle program for preventing unhealthy weight gain in young adults: study protocol for a randomized controlled trial. Trials 14:75. 10.1186/1745-6215-14-75
    1. Henry R. R., Chilton R., Garvey W. T. (2013). New options for the treatment of obesity and type 2 diabetes mellitus (narrative review). J. Diabetes Complications 27 508–518 10.1016/j.jdiacomp.2013.04.011
    1. Hill A. J. (2005). Psychological aspects of obesity. Psychiatry 4 26–30 10.1383/psyt.4.4.26.63443
    1. Hilty D. M., Ferrer D. C., Parish M. B., Johnston B., Callahan E. J., Yellowlees P. M. (2013). The effectiveness of telemental health: a 2013 review. Telemed. J. E Health 19 444–454 10.1089/tmj.2013.0075
    1. Hudson J. I., Hiripi E., Pope H. G., Jr., Kessler R. C. (2007). The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol. Psychiatry 61 348–358 10.1016/j.biopsych.2006.03.040
    1. Jeffery R. W., Wing R. R., Mayer R. R. (1998). Are smaller weight losses or more achievable weight loss goals better in the long term for obese patients? J. Consult Clin. Psychol. 66 641–645 10.1037/0022-006X.66.4.641
    1. Jensen C. D., Aylward B. S., Steele R. G. (2012). Predictors of attendance in a practical clinical trial of two pediatric weight management interventions. Obesity (Silver Spring) 20 2250–2256 10.1038/oby.2012.96
    1. Khaylis A., Yiaslas T., Bergstrom J., Gore-Felton C. (2010). A review of efficacious technology-based weight-loss interventions: five key components. Telemed. J. E Health 16 931–938 10.1089/tmj.2010.0065
    1. Kushner R. F. (2014). Weight loss strategies for treatment of obesity. Prog. Cardiovasc. Dis. 56 465–472 10.1016/j.pcad.2013.09.005
    1. Manzoni G. M., Castelnuovo G., Molinari E. (2008). Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N. Engl. J. Med. 359 229–241 10.1056/NEJMoa0708681
    1. Manzoni G. M., Cribbie R. A., Villa V., Arpin-Cribbie C. A., Gondoni L., Castelnuovo G. (2010). Psychological well-being in obese inpatients with ischemic heart disease at entry and at discharge from a four-week cardiac rehabilitation program. Front. Psychol. 1:38. 10.3389/fpsyg.2010.00038
    1. Manzoni G. M., Pagnini F., Corti S., Molinari E., Castelnuovo G. (2011a). Internet-based behavioral interventions for obesity: an updated systematic review. Clin. Pract. Epidemiol. Ment. Health 7 19–28 10.2174/1745017901107010019
    1. Manzoni G. M., Villa V., Compare A., Castelnuovo G., Nibbio F., Titon A. M., et al. (2011b). Short-term effects of a multi-disciplinary cardiac rehabilitation programme on psychological well-being, exercise capacity and weight in a sample of obese in-patients with coronary heart disease: a practice-level study. Psychol. Health Med. 16 178–189 10.1080/13548506.2010.542167
    1. Marcus M. D., Wildes J. E. (2009). Obesity: is it a mental disorder? Int. J. Eat. Disord. 42 739–753 10.1002/eat.20725
    1. Martinez-Perez B., de la Torre-Diez I., Lopez-Coronado M. (2013). Mobile health applications for the most prevalent conditions by the World Health Organization: review and analysis. J. Med. Internet Res. 15:e120. 10.2196/jmir.2600
    1. Murphy R., Straebler S., Cooper Z., Fairburn C. G. (2010). Cognitive behavioral therapy for eating disorders. Psychiatr. Clin. North Am. 33 611–627 10.1016/j.psc.2010.04.004
    1. Nguyen T., Lau D. C. (2012). The obesity epidemic and its impact on hypertension. Can. J. Cardiol. 28 326–333 10.1016/j.cjca.2012.01.001
    1. Nonas C. A., Foster G. D. (2005). Setting achievable goals for weight loss. J. Am. Diet. Assoc. 105(Suppl. 1) S118–S123 10.1016/j.jada.2005.02.030
    1. O’Neil P. M., Smith C. F., Foster G. D., Anderson D. A. (2000). The perceived relative worth of reaching and maintaining goal weight. Int. J. Obes. Relat. Metab. Disord. 24 1069–1076 10.1038/sj.ijo.0801242
    1. Park M. J., Kim H. S. (2012). Evaluation of mobile phone and Internet intervention on waist circumference and blood pressure in post-menopausal women with abdominal obesity. Int. J. Med. Inform. 81 388–394 10.1016/j.ijmedinf.2011.12.011
    1. Patham B., Mukherjee D, San Juan Z. T. (2014). Contemporary review of drugs used to treat obesity. Cardiovasc. Hematol. Agents Med. Chem. 11 272–280 10.2174/1871525712666140317162655
    1. Pellegrini C. A., Duncan J. M., Moller A. C., Buscemi J., Sularz A., DeMott A., et al. (2012). A smartphone-supported weight loss program: design of the ENGAGED randomized controlled trial. BMC Public Health 12:1041. 10.1186/1471-2458-12-1041
    1. Petry N. M., Barry D., Pietrzak R. H., Wagner J. A. (2008). Overweight and obesity are associated with psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychosom. Med. 70 288–297 10.1097/PSY.0b013e3181651651
    1. Pickering R. P., Grant B. F., Chou S. P., Compton W. M. (2007). Are overweight, obesity, and extreme obesity associated with psychopathology? Results from the national epidemiologic survey on alcohol and related conditions. J. Clin. Psychiatry 68 998–1009 10.4088/JCP.v68n0704
    1. Pietrabissa G., Manzoni G. M., Corti S., Vegliante N., Molinari E., Castelnuovo G. (2012). Addressing motivation in globesity treatment: a new challenge for clinical psychology. Front. Psychol. 3:317. 10.3389/fpsyg.2012.00317
    1. Rao G., Burke L. E., Spring B. J., Ewing L. J., Turk M., Lichtenstein A. H., et al. (2011). New and emerging weight management strategies for busy ambulatory settings: a scientific statement from the American Heart Association endorsed by the Society of Behavioral Medicine. Circulation 124 1182–1203 10.1161/CIR.0b013e31822b9543
    1. Rees C. S., Stone S. (2005). Therapeutic alliance in face- to-face versus videoconferenced psychotherapy. Prof. Psychol. Res. Pr. 36 649–653 10.1037/0735-7028.36.6.649
    1. Riper H., Andersson G., Christensen H., Cuijpers P., Lange A., Eysenbach G. (2010). Theme issue on e-mental health: a growing field in internet research. J. Med. Internet Res. 12:e74. 10.2196/jmir.1713
    1. Riva G., Castelnuovo G., Mantovani F. (2006). Transformation of flow in rehabilitation: the role of advanced communication technologies. Behav. Res. Methods 38 237–244 10.3758/BF03192775
    1. Rodrigues J. J., Lopes I. M., Silva B. M, Torre Ide L. (2013). A new mobile ubiquitous computing application to control obesity: SapoFit. Inform. Health Soc. Care 38 37–53 10.3109/17538157.2012.674586
    1. Rojas S. V., Gagnon M. P. (2008). A systematic review of the key indicators for assessing telehomecare cost-effectiveness. Telemed. J. E Health 14 896–904 10.1089/tmj.2008.0009
    1. Rueda-Clausen C. F., Padwal R. S., Sharma A. M. (2013). New pharmacological approaches for obesity management. Nat. Rev. Endocrinol. 9 467–478 10.1038/nrendo.2013.113
    1. Sandoval D. (2011). Bariatric surgeries: beyond restriction and malabsorption. Int. J. Obes. (Lond.) 35(Suppl. 3) S45–S49 10.1038/ijo.2011.148
    1. Schag K., Schonleber J., Teufel M., Zipfel S., Giel K. E. (2013). Food-related impulsivity in obesity and binge eating disorder–a systematic review. Obes. Rev. 14 477–495 10.1111/obr.12017
    1. Schiel R., Kaps A., Bieber G. (2012). Electronic health technology for the assessment of physical activity and eating habits in children and adolescents with overweight and obesity IDA. Appetite 58 432–437 10.1016/j.appet.2011.11.021
    1. Schoffman D. E., Turner-McGrievy G., Jones S. J., Wilcox S. (2013). Mobile apps for pediatric obesity prevention and treatment, healthy eating, and physical activity promotion: just fun and games? Trans. Behav. Med. 3 320–325 10.1007/s13142-013-0206-3
    1. Scott K. M., Bruffaerts R., Simon G. E., Alonso J., Angermeyer M., de Girolamo G., et al. (2008). Obesity and mental disorders in the general population: results from the world mental health surveys. Int. J. Obes. (Lond.) 32 192–200 10.1038/sj.ijo.0803701
    1. Sharifi M., Dryden E. M., Horan C. M., Price S., Marshall R., Hacker K., et al. (2013). Leveraging text messaging and mobile technology to support pediatric obesity-related behavior change: a qualitative study using parent focus groups and interviews. J. Med. Internet Res. 15:e272. 10.2196/jmir.2780
    1. Shaw K., O’Rourke P., Del Mar C., Kenardy J. (2005). Psychological interventions for overweight or obesity. Cochrane Database Syst. Rev. 18 CD003818
    1. Shaw R. J., Bosworth H. B., Silva S. S., Lipkus I. M., Davis L. L., Sha R. S., et al. (2013). Mobile health messages help sustain recent weight loss. Am. J. Med. 126 1002–1009 10.1016/j.amjmed.2013.07.001
    1. Simpson S. A., Shaw C., McNamara R. (2011). What is the most effective way to maintain weight loss in adults? BMJ 343 d8042 10.1136/bmj.d8042
    1. Simpson S. G., Slowey L. (2011). Video therapy for atypical eating disorder and obesity: a case study. Clin. Pract. Epidemiol. Ment. Health 7 38–43 10.2174/1745017901107010038
    1. Swencionis C., Rendell S. L. (2012). The psychology of obesity. Abdom. Imaging 37 733–737 10.1007/s00261-012-9863-9
    1. Tufano J. T., Karras B. T. (2005). Mobile eHealth interventions for obesity: a timely opportunity to leverage convergence trends. J. Med. Internet Res. 7:e58. 10.2196/jmir.7.5.e58
    1. Turner-McGrievy G. M., Beets M. W., Moore J. B., Kaczynski A. T., Barr-Anderson D. J., Tate D. F. (2013). Comparison of traditional versus mobile app self-monitoring of physical activity and dietary intake among overweight adults participating in an mHealth weight loss program. J. Am. Med. Inform. Assoc. 20 513–518 10.1136/amiajnl-2012-001510
    1. Villa V., Manzoni G. M., Pagnini F., Castelnuovo G., Cesa G. L., Molinari E. (2009). Do coping strategies discriminate eating disordered individuals better than eating disorder features? An explorative study on female inpatients with anorexia and bulimia nervosa. J. Clin. Psychol. Med. Settings 16 297–303 10.1007/s10880-009-9172-9
    1. Wadden T. A., Anderson D. A., Foster G. D., Bennett A., Steinberg C., Sarwer D. B. (2000). Obese women’s perceptions of their physicians’ weight management attitudes and practices. Arch. Fam. Med. 9 854–860 10.1001/archfami.9.9.854
    1. Wang G. J., Volkow N. D., Fowler J. S. (2002). The role of dopamine in motivation for food in humans: implications for obesity. Expert Opin. Ther. Targets 6 601–609 10.1517/14728222.6.5.601
    1. Wang G. J., Volkow N. D., Logan J., Pappas N. R., Wong C. T., Zhu W., et al. (2001). Brain dopamine and obesity. Lancet 357 354–357 10.1016/S0140-6736(00)03643-6
    1. Wang G. J., Volkow N. D., Thanos P. K., Fowler J. S. (2004). Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review. J. Addict. Dis. 23 39–53 10.1300/J069v23n03_04
    1. Wang G. J., Volkow N. D., Thanos P. K., Fowler J. S. (2009). Imaging of brain dopamine pathways: implications for understanding obesity. J. Addict. Med, 3 8–18 10.1097/ADM.0b013e31819a86f7
    1. Whitlock G., Lewington S., Sherliker P., Clarke R., Emberson J., Halsey J., et al. (2009). Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 373 1083–1096 10.1016/S0140-6736(09)60318-4
    1. Whittaker R. (2012). Issues in mHealth: findings from key informant interviews. J. Med. Internet Res. 14:e129. 10.2196/jmir.1989
    1. Wilson G. T. (2011). Treatment of binge eating disorder. Psychiatr. Clin. North Am. 34 773–783 10.1016/j.psc.2011.08.011
    1. Wing R. R. (2002). “Behavioral weight control,” in Handbook of Obesity Treatment eds Wadden T. A., Stunkard A. J. (New York: Guilford Press; ) 301–316

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