Development of intimal lesions after leukocyte migration into the vascular wall

M F Prescott, C K McBride, M Court, M F Prescott, C K McBride, M Court

Abstract

A model was developed to study the role of leukocytes in the development of vascular lesions. Implantation of an endotoxin-soaked cotton thread in the adventitia on the ventral side of the rat femoral artery resulted in leukocyte migration into the vessel wall exclusively in the ventral half of the vessel. Leukocyte migration occurred from both the luminal and adventitial side and consisted of neutrophils and mononuclear cells. Smooth muscle cell rich intimal lesions localized to the ventral half of the vessel were first observed 1 week after implantation. Lesions remained localized to the ventral half of the vessel wall through the 6th week. When leukocyte migration into the vessel wall was inhibited by treatment with dexamethasone, lesion development did not occur. These results suggest that leukocytes can stimulate smooth muscle cell migration into the intima and result in intimal lesion formation.

References

    1. Thromb Res. 1982 Jul 15;27(2):205-10
    1. Lab Invest. 1981 Apr;44(4):301-8
    1. Arteriosclerosis. 1986 Mar-Apr;6(2):131-8
    1. Proc Soc Exp Biol Med. 1976 Nov;153(2):236-40
    1. Agents Actions. 1986 Jan;17(3-4):255-62
    1. Lab Invest. 1988 Mar;58(3):310-5
    1. Physiol Rev. 1979 Jan;59(1):1-61
    1. Lab Invest. 1972 Sep;27(3):341-50
    1. Atherosclerosis. 1987 Apr;64(2-3):243-54
    1. Am J Cardiol. 1984 Apr 1;53(8):997-9
    1. J Pathol Bacteriol. 1966 Apr;91(2):575-87
    1. Atherosclerosis. 1973 May-Jun;17(3):515-22
    1. Arteriosclerosis. 1984 Jul-Aug;4(4):323-40
    1. Am J Pathol. 1967 Nov;51(5):681-719
    1. Virchows Arch A Pathol Anat Histopathol. 1985;405(2):175-91
    1. Atherosclerosis. 1987 Oct;67(2-3):229-36
    1. J Biol Chem. 1987 Feb 5;262(4):1698-705
    1. Atherosclerosis. 1971 May-Jun;13(3):319-31
    1. Atherosclerosis. 1988 May;71(1):35-43
    1. Primates Med. 1976;9:359-95
    1. Eur J Pharmacol. 1986 Sep 23;129(1-2):65-76
    1. Am J Pathol. 1981 May;103(2):181-90
    1. Arteriosclerosis. 1981 Sep-Oct;1(5):293-311
    1. Am Rev Respir Dis. 1987 Jan;135(1):66-71
    1. FASEB J. 1987 Aug;1(2):89-96
    1. Virchows Arch A Pathol Anat Histol. 1982;396(1):41-59
    1. Atherosclerosis. 1982 Jun;43(2-3):259-75
    1. Nature. 1977 Oct 27;269(5631):804-6
    1. Am J Pathol. 1974 Aug;76(2):245-64
    1. Arteriosclerosis. 1983 May-Jun;3(3):206-14
    1. Am J Pathol. 1976 Jan;82(1):157-70
    1. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2303-6
    1. Lancet. 1954 May 1;266(6818):891-5
    1. Exp Mol Pathol. 1979 Aug;31(1):1-9
    1. Am J Pathol. 1988 Aug;132(2):319-29
    1. Am J Pathol. 1971 Mar;62(3):391-414
    1. Br J Pharmacol. 1982 May;76(1):185-94
    1. Lab Invest. 1985 Jul;53(1):80-90
    1. J Leukoc Biol. 1987 Jun;41(6):465-73
    1. Virchows Arch A Pathol Pathol Anat. 1969;347(3):197-210
    1. Lab Invest. 1981 Nov;45(5):435-41
    1. Curr Top Pathol. 1975;60:1-32
    1. Am J Pathol. 1983 Dec;113(3):341-58
    1. Exp Mol Pathol. 1978 Aug;29(1):12-28
    1. AMA Arch Pathol. 1959 Aug;68(2):143-7
    1. J Immunol. 1982 Nov;129(5):1803-5
    1. Exp Mol Pathol. 1986 Jun;44(3):344-52
    1. J Cell Biol. 1984 Feb;98(2):534-40
    1. Immunol Rev. 1982;65:133-55
    1. Exp Mol Pathol. 1970 Jun;12(3):354-62
    1. Med Sci Sports Exerc. 1987 Jun;19(3):213-7
    1. J Immunol. 1984 Oct;133(4):2169-73
    1. Circulation. 1962 Jul;26:73-8
    1. J Clin Invest. 1986 Dec;78(6):1432-8
    1. J Leukoc Biol. 1988 Apr;43(4):349-56
    1. J Immunol. 1979 Aug;123(2):751-4
    1. Exp Mol Pathol. 1987 Feb;46(1):78-88
    1. Eur J Pharmacol. 1984 May 18;101(1-2):11-6

Source: PubMed

Sponsoren und Mitarbeiter

Krankheiten

Drogeninterventionen

3
Abonnieren