Blunted Muscle Mitochondrial Responses to Exercise Training in Older Adults With HIV
Catherine M Jankowski, Melissa P Wilson, Samantha MaWhinney, Jane Reusch, Leslie Knaub, Sara Hull, Kristine M Erlandson, Catherine M Jankowski, Melissa P Wilson, Samantha MaWhinney, Jane Reusch, Leslie Knaub, Sara Hull, Kristine M Erlandson
Abstract
Background: Muscle mitochondrial dysfunction associated with HIV and antiretroviral therapy (ART) may improve with exercise.
Methods: Muscle specimens obtained before and after 24 weeks of exercise in older people with HIV (PWH; n = 18; ART >2 years) and uninfected controls (n = 21) were analyzed for citrate synthase (CS) activity and complexes (C) I-V, manganese superoxide dismutase (MnSOD), peroxisome proliferator-activated receptor-γ coactivator-1 (PGC1α), and voltage-dependent anion channel 1 (VDAC1) content.
Results: Only controls had increased CS, MnSOD, PGC1α, and CIV (P ≤ .01; P < .01 vs PWH) after training.
Conclusions: The blunted mitochondrial adaptations to training in PWH suggests the need for different types of exercise-induced stimulation.
Clinical trials registration: NCT02404792.
Keywords: HIV; aging; exercise; exercise training; mitochondrial function; skeletal muscle.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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Source: PubMed