Adapting Chinese Qigong Mind-Body Exercise for Healthy Aging in Older Community-Dwelling Low-income Latino Adults: Pilot Feasibility Study

Zenong Yin, Cristina E Martinez, Shiyu Li, Martha Martinez, Kezhi Peng, William M Land, Sarah L Ullevig, Adelita Cantu, Sharon Falk, Arthur E Hernández, Catherine Ortega, Deborah Parra-Medina, Maureen J Simmonds, Zenong Yin, Cristina E Martinez, Shiyu Li, Martha Martinez, Kezhi Peng, William M Land, Sarah L Ullevig, Adelita Cantu, Sharon Falk, Arthur E Hernández, Catherine Ortega, Deborah Parra-Medina, Maureen J Simmonds

Abstract

Background: Research translating the evidence for the benefit of mind-body exercise in older Latinos with limited access to community-based healthy aging programs is sparse.

Objective: This study aimed to evaluate the feasibility of Function Improvement Exercises for Older Sedentary Community-Dwelling Latino Residents (FITxOlder), a Community Health Worker (CHW)-led, mobile technology-facilitated Chinese Qigong mind-body exercise program for healthy aging and to explore its impact on physical and cognitive function and quality of life (QoL) in older community-dwelling low-income Latino adults.

Methods: This study was designed as a Stage 1 feasibility study to develop and pilot-test FITxOlder. In Phase 1 (Stage 1A), a working group of seniors, CHWs, and senior center staff guided the adaptation of Chinese Qigong into a healthy aging program. In Phase 2 (Stage 1B), 49 older Latino adults participated in a 3-arm controlled study to test the feasibility and preliminary effect of CHW-led FITxOlder on physical and cognitive function and QoL measures over 16 weeks.

Results: Although the COVID-19 pandemic disrupted the implementation of the study protocol, we found favorable results regarding participant recruitment, retention, and fidelity of implementation. Notable findings included an 89.3% participant retention, 79.4% of the participants completed at least 70% of the weekly exercise goal, and no report of adverse events. The effects on intervention outcome measures were modest.

Conclusions: FITxOlder is feasible for promoting healthy aging in older Latino adults; future research needs to compare its feasibility with other low-impact exercise programs for healthy aging using a randomized controlled trial.

Trial registration: ClinicalTrials.gov NCT04284137; https://ichgcp.net/clinical-trials-registry/NCT04284137.

Keywords: community-based participatory research; five animal play; mHealth; wuqinxi.

Conflict of interest statement

Conflicts of Interest: None declared.

©Zenong Yin, Cristina E Martinez, Shiyu Li, Martha Martinez, Kezhi Peng, William M Land, Sarah L Ullevig, Adelita Cantu, Sharon Falk, Arthur E Hernández, Catherine Ortega, Deborah Parra-Medina, Maureen J Simmonds. Originally published in JMIR Aging (https://aging.jmir.org), 01.11.2021.

Figures

Figure 1
Figure 1
Subscale scores of the Exercise-induced Feeling Inventory from Group Sessions 1 to 8.

References

    1. The Adminstration for Community Living. Profile of Older Americans. 2019. [2021-10-13]. .
    1. Brenner AB, Clarke PJ. Understanding Socioenvironmental Contributors to Racial and Ethnic Disparities in Disability Among Older Americans. Res Aging. 2018 Feb 01;40(2):103–130. doi: 10.1177/0164027516681165. 0164027516681165
    1. Christine B, Teague R, Melissa B. Multiple Chronic Conditions in the United States. Multiple Chronic Conditions in the United States: RAND Corporation; 2017.
    1. Ashman JJ, Beresovsky V. Multiple chronic conditions among US adults who visited physician offices: data from the National Ambulatory Medical Care Survey, 2009. Prev Chronic Dis. 2013 Apr 25;10:E64. doi: 10.5888/pcd10.120308. E64
    1. Ward BW, Schiller JS. Prevalence of multiple chronic conditions among US adults: estimates from the National Health Interview Survey, 2010. Prev Chronic Dis. 2013 Apr 25;10:E65. doi: 10.5888/pcd10.120203. E65
    1. The US Dept of Health and Human Service . Physical activity guidelines for Americans, 2nd edition. Washington, DC: US Dept of Health and Human Service; 2018.
    1. Watson KB, Carlson SA, Gunn JP, Galuska DA, O'Connor A, Greenlund KJ, Fulton JE. Physical Inactivity Among Adults Aged 50 Years and Older - United States, 2014. MMWR Morb Mortal Wkly Rep. 2016 Sep 16;65(36):954–8. doi: 10.15585/mmwr.mm6536a3. doi: 10.15585/mmwr.mm6536a3.
    1. Olanrewaju O, Kelly S, Cowan A, Brayne C, Lafortune L. Physical Activity in Community Dwelling Older People: A Systematic Review of Reviews of Interventions and Context. PLoS One. 2016 Dec;11(12):e0168614. doi: 10.1371/journal.pone.0168614. PONE-D-16-34254
    1. Zubala A, MacGillivray S, Frost H, Kroll T, Skelton DA, Gavine A, Gray NM, Toma M, Morris J. Promotion of physical activity interventions for community dwelling older adults: A systematic review of reviews. PLoS One. 2017;12(7):e0180902. doi: 10.1371/journal.pone.0180902. PONE-D-17-02269
    1. Sansano-Nadal O, Gine-Garriga M, Brach JS, Wert DM, Jerez-Roig J, Gueraa-Balic M, Oviedo G, Fortuno J, Gomara-Toldra N, Soto-Bagaria L, Perez LM, Inzitari M, Sola I, Martin-Borras C, Roche M. Exercise-Based Interventions to Enhance Long-Term Sustainability of Physical Activity in Older Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Int J Environ Res Public Health. 2019 Jul 15;16(14):2527. doi: 10.3390/ijerph16142527. ijerph16142527
    1. National Center for Complementary and Alternative Medicine . Exploring the Science of Complementary and Alternative Medicine. Washington, DC: U.S. Department of Health and Human Services, National Institutes of Health; 2011.
    1. Sharp D, Lorenc A, Morris R, Feder G, Little P, Hollinghurst S, Mercer SW, MacPherson H. Complementary medicine use, views, and experiences: a national survey in England. BJGP Open. 2018 Dec;2(4):bjgpopen18X101614. doi: 10.3399/bjgpopen18X101614. 01614
    1. Larkey L, Jahnke R, Etnier J, Gonzalez J. Meditative movement as a category of exercise: implications for research. J Phys Act Health. 2009 Mar;6(2):230–8. doi: 10.1123/jpah.6.2.230.
    1. Chen X, Cui J, Li R, Norton R, Park J, Kong J, Yeung A. Dao Yin (a.k.a. Qigong): Origin, Development, Potential Mechanisms, and Clinical Applications. Evid Based Complement Alternat Med. 2019;2019:3705120. doi: 10.1155/2019/3705120. doi: 10.1155/2019/3705120.
    1. Wang YT, Huang G, Duke G, Yang Y. Tai Chi, Yoga, and Qigong as Mind-Body Exercises. Evidence-Based Complementary and Alternative Medicine. 2017;2017:1–1. doi: 10.1155/2017/8763915.
    1. Horowitz S. Evidence-Based Health Benefits of. Alternative and Complementary Therapies. 2009 Aug;15(4):178–183. doi: 10.1089/act.2009.15401.
    1. Jahnke R, Larkey L, Rogers C, Etnier J, Lin F. A comprehensive review of health benefits of qigong and tai chi. Am J Health Promot. 2010;24(6):e1–e25. doi: 10.4278/ajhp.081013-LIT-248.
    1. Klein PJ, Baumgarden J, Schneider R. Qigong and Tai Chi as Therapeutic Exercise: Survey of Systematic Reviews and Meta-Analyses Addressing Physical Health Conditions. Altern Ther Health Med. 2019 Oct;25(5):48–53.AT5817
    1. Zhang Y, Hu R, Han M, Lai B, Liang S, Chen B, Robinson N, Chen K. Evidence Base of Clinical Studies on Qi Gong: A Bibliometric Analysis. Complementary Therapies in Medicine. 2020:50. doi: 10.1016/j.ctim.2020.102392. doi: 10.1016/j.ctim.2020.102392.
    1. Kelley GA, Kelley KS. Meditative Movement Therapies and Health-Related Quality-of-Life in Adults: A Systematic Review of Meta-Analyses. PLoS One. 2015;10(6):e0129181. doi: 10.1371/journal.pone.0129181. PONE-D-14-49605
    1. Morgan N, Irwin MR, Chung M, Wang C. The effects of mind-body therapies on the immune system: meta-analysis. PLoS One. 2014;9(7):e100903. doi: 10.1371/journal.pone.0100903. PONE-D-14-00315
    1. Oh B, Bae K, Lamoury G, Eade T, Boyle F, Corless B, Clarke S, Yeung A, Rosenthal D, Schapira L, Back M. The Effects of Tai Chi and Qigong on Immune Responses: A Systematic Review and Meta-Analysis. Medicines (Basel) 2020 Jun 30;7(7):Epub. doi: 10.3390/medicines7070039. medicines7070039
    1. Morone NE, Greco CM. Mind–Body Interventions for Chronic Pain in Older Adults: A Structured Review: Table 1. Pain Med. 2007 May 01;8(4):359–375. doi: 10.1111/j.1526-4637.2007.00312.x.
    1. Larkey LK, Roe DJ, Weihs KL, Jahnke R, Lopez AM, Rogers CE, Oh B, Guillen-Rodriguez J. Randomized controlled trial of Qigong/Tai Chi Easy on cancer-related fatigue in breast cancer survivors. Ann Behav Med. 2015 May;49(2):165–76. doi: 10.1007/s12160-014-9645-4.
    1. Jahnke R, Larkey L, Rogers C. Dissemination and benefits of a replicable Tai Chi and Qigong program for older adults. Geriatr Nurs. 2010;31(4):272–80. doi: 10.1016/j.gerinurse.2010.04.012. doi: 10.1016/j.gerinurse.2010.04.012.S0197-4572(10)00214-4
    1. Kemp CA. Qigong as a therapeutic intervention with older adults. J Holist Nurs. 2004 Dec 24;22(4):351–73. doi: 10.1177/0898010104269313.22/4/351
    1. Dong X, Bergren S. Qigong among older adults: a global review. Clin Res Trial. 2016;2(1):120. doi: 10.15761/crt.1000130.
    1. Hansen-Kyle L. A concept analysis of healthy aging. Nurs Forum. 2005 Apr;40(2):45–57. doi: 10.1111/j.1744-6198.2005.00009.x.NUF009
    1. Depp CA, Glatt SJ, Jeste DV. Recent advances in research on successful or healthy aging. Curr Psychiatry Rep. 2007 Feb;9(1):7–13. doi: 10.1007/s11920-007-0003-0.
    1. Jonkman NH, van Schooten KS, Maier AB, Pijnappels M. eHealth interventions to promote objectively measured physical activity in community-dwelling older people. Maturitas. 2018 Jul;113:32–39. doi: 10.1016/j.maturitas.2018.04.010.S0378-5122(18)30215-9
    1. Nápoles AM, Stewart AL. Transcreation: an implementation science framework for community-engaged behavioral interventions to reduce health disparities. BMC Health Serv Res. 2018 Sep 12;18(1):710. doi: 10.1186/s12913-018-3521-z. 10.1186/s12913-018-3521-z
    1. Pasick RJ, D'onofrio CN, Otero-Sabogal R. Similarities and Differences Across Cultures: Questions to Inform a Third Generation for Health Promotion Research. Health Education Quarterly. 2016 Aug 26;23(1_suppl):142–161. doi: 10.1177/109019819602301s11.
    1. Stage model for behavioral intervention development. National Institutes of Health and National Institute on Aging. 2019. [2021-10-13]. .
    1. Onken LS, Carroll KM, Shoham V, Cuthbert BN, Riddle M. Reenvisioning Clinical Science: Unifying the Discipline to Improve the Public Health. Clin Psychol Sci. 2014 Jan 01;2(1):22–34. doi: 10.1177/2167702613497932.
    1. Yin Z, Li S, Land WM, Ullevig SL, Juarez F, Hernández AE, Ortega C, Patel NK, Simmonds MJ. Higher levels of physical activity buffered the negative effect of pain severity on physical frailty in older Latinx adults. Geriatr Nurs. 2021;42(2):460–466. doi: 10.1016/j.gerinurse.2021.02.004.S0197-4572(21)00062-8
    1. Sofolahan-Oladeinde Y, Mullins CD, Baquet CR. Using community-based participatory research in patient-centered outcomes research to address health disparities in under-represented communities. J Comp Eff Res. 2015 Sep;4(5):515–23. doi: 10.2217/cer.15.31.
    1. Center for Community Health Development . Chapter 19 Choosing and Adapting Community Interventions. Lawrence Ks: The University of Kansas; 1994. p. 19.
    1. Chinese Health Qigong Association . Chinese Health Qigong: Wu Qin Xi. Beijing, China: Foreign Language Press; 2007.
    1. Chinese Health Qigong Association . Chinese Health Qigong: Ba Duan Jin. Beijing, China: Foreign Language Press; 2010.
    1. Balaneskovic S. Hua Tuo's Wu Qin Xi (Five Animal Frolics) movements and the logic behind it. Chin Med Cult. 2018;1(3):127. doi: 10.4103/cmac.cmac_32_18.
    1. Romero M, Hondagneu-Sotelo P, Ortiz V, editors. Challenging fronteras: Structuring Latina and Latino lives in the U.S. An anthology of readings. New York: Routledge; 1997.
    1. Lee L, Arthur A, Avis M. Using self-efficacy theory to develop interventions that help older people overcome psychological barriers to physical activity: a discussion paper. Int J Nurs Stud. 2008 Nov;45(11):1690–9. doi: 10.1016/j.ijnurstu.2008.02.012.S0020-7489(08)00059-X
    1. Dorcas A, Yung P. Qigong: Harmonising the breath, the body and the mind. Complementary Therapies in Nursing and Midwifery. 2003 Nov;9(4):198–202. doi: 10.1016/S1353-6117(03)00053-2. doi: 10.1016/s1353-6117(03)00053-2.
    1. Larkey L, Jahnke R, Etnier J, Gonzalez J. Meditative movement as a category of exercise: implications for research. J Phys Act Health. 2009 Mar;6(2):230–8. doi: 10.1123/jpah.6.2.230.
    1. National Council on Aging Aging Mastery Program® Research and Evidence-Base. [2020-12-15]. .
    1. Lise G, Rejeski W. The Exercise-Induced Feeling Inventory: Development and Initial Validation. Journal of Sport and Exercise Psychology. 1993;15(4):403–23. doi: 10.1123/jsep.15.4.403.
    1. Attkisson CC, Greenfield TK. The use of psychological testing for treatment planning outcome assessment. Hillsdale, NJ, US: Lawrence Erlbaum Associates, Inc; 1994. Client Satisfaction Questionnaire-8Service Satisfaction Scale-30; pp. 402–20.
    1. Calder PC, Carding SR, Christopher G, Kuh D, Langley-Evans SC, McNulty H. A holistic approach to healthy ageing: how can people live longer, healthier lives? J Hum Nutr Diet. 2018 Aug;31(4):439–450. doi: 10.1111/jhn.12566.
    1. Jette AM, Davies AR, Cleary PD, Calkins DR, Rubenstein LV, Fink A, Kosecoff J, Young RT, Brook RH, Delbanco TL. The Functional Status Questionnaire: reliability and validity when used in primary care. J Gen Intern Med. 1986;1(3):143–9. doi: 10.1007/BF02602324.
    1. Smith A. Symbol digit modalities test: Manual. Los Angeles, CA: Western Psychological Services; 1982.
    1. Simmonds MJ, Olson SL, Jones S, Hussein T, Lee CE, Novy D, Radwan H. Psychometric characteristics and clinical usefulness of physical performance tests in patients with low back pain. Spine (Phila Pa 1976) 1998 Nov 15;23(22):2412–21. doi: 10.1097/00007632-199811150-00011.
    1. Ware JJ, Kosinski M, Turner-Bowker D, Sundaram M, Gandek BM. User's manual for the SF-12v2 Health Survey 2nd ed. Lincoln, RI: QualityMetric Incorporated; 2009.
    1. Poquet N, Lin C. The Brief Pain Inventory (BPI) J Physiother. 2016 Jan;62(1):52. doi: 10.1016/j.jphys.2015.07.001. S1836-9553(15)00075-2
    1. Bohlmeijer E, ten Klooster PM, Fledderus M, Veehof M, Baer R. Psychometric properties of the five facet mindfulness questionnaire in depressed adults and development of a short form. Assessment. 2011 Sep;18(3):308–20. doi: 10.1177/1073191111408231.1073191111408231
    1. Myers JS, Mitchell M, Krigel S, Steinhoff A, Boyce-White A, Van Goethem K, Valla M, Dai J, He J, Liu W, Sereika SM, Bender CM. Qigong intervention for breast cancer survivors with complaints of decreased cognitive function. Support Care Cancer. 2019 Apr;27(4):1395–1403. doi: 10.1007/s00520-018-4430-8. 10.1007/s00520-018-4430-8
    1. Oh B, Butow P, Mullan B, Clarke S, Beale P, Pavlakis N, Kothe E, Lam L, Rosenthal D. Impact of medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial. Ann Oncol. 2010 Mar;21(3):608–614. doi: 10.1093/annonc/mdp479. S0923-7534(19)38318-8
    1. Sarmento CVM, Moon S, Pfeifer T, Smirnova IV, Colgrove Y, Lai SM, Liu W. The therapeutic efficacy of Qigong exercise on the main symptoms of fibromyalgia: A pilot randomized clinical trial. Integr Med Res. 2020 Dec;9(4):100416. doi: 10.1016/j.imr.2020.100416. S2213-4220(20)30048-2
    1. Logghe I, Verhagen A, Rademaker A, Zeeuwe P, Bierma-Zeinstra S, Van Rossum E, Faber M, Van Haastregt JCM, Koes B. Explaining the ineffectiveness of a Tai Chi fall prevention training for community-living older people: a process evaluation alongside a randomized clinical trial (RCT) Arch Gerontol Geriatr. 2011;52(3):357–62. doi: 10.1016/j.archger.2010.05.013. doi: 10.1016/j.archger.2010.05.013.S0167-4943(10)00138-X
    1. Katrancha ED, Hoffman LA, Zullo TG, Tuite PK, Garand L. Effects of a video guided T'ai Chi group intervention on center of balance and falls efficacy: a pilot study. Geriatr Nurs. 2015;36(1):9–14. doi: 10.1016/j.gerinurse.2014.08.015. S0197-4572(14)00417-0
    1. Fong SSM, Ng SSM, Lee HW, Pang MYC, Luk WS, Chung JWY, Wong JYH, Masters RSW. The effects of a 6-month Tai Chi Qigong training program on temporomandibular, cervical, and shoulder joint mobility and sleep problems in nasopharyngeal cancer survivors. Integr Cancer Ther. 2015 Jan 18;14(1):16–25. doi: 10.1177/1534735414556508. 1534735414556508
    1. Day L, Hill K, Stathakis V, Flicker L, Segal L, Cicuttini F, Jolley D. Impact of tai-chi on falls among preclinically disabled older people. A randomized controlled trial. J Am Med Dir Assoc. 2015 May 01;16(5):420–6. doi: 10.1016/j.jamda.2015.01.089. doi: 10.1016/j.jamda.2015.01.089.S1525-8610(15)00096-1
    1. Ortiz BI, Shields KM, Clauson KA, Clay PG. Complementary and alternative medicine use among Hispanics in the United States. Ann Pharmacother. 2007 Jun;41(6):994–1004. doi: 10.1345/aph.1H600.aph.1H600
    1. Cherniack EP, Ceron-Fuentes J, Florez H, Sandals L, Rodriguez O, Palacios JC. Influence of race and ethnicity on alternative medicine as a self-treatment preference for common medical conditions in a population of multi-ethnic urban elderly. Complement Ther Clin Pract. 2008 May;14(2):116–23. doi: 10.1016/j.ctcp.2007.11.002.S1744-3881(07)00076-X
    1. Rhodes RE, Kates A. Can the Affective Response to Exercise Predict Future Motives and Physical Activity Behavior? A Systematic Review of Published Evidence. Ann Behav Med. 2015 Oct;49(5):715–31. doi: 10.1007/s12160-015-9704-5.
    1. Barnett F. The effect of exercise on affective and self-efficacy responses in older and younger women. J Phys Act Health. 2013 Jan;10(1):97–105. doi: 10.1123/jpah.10.1.97.2010-0230
    1. Schutzer K, Graves B. Barriers and motivations to exercise in older adults. Prev Med. 2004 Nov;39(5):1056–61. doi: 10.1016/j.ypmed.2004.04.003. doi: 10.1016/j.ypmed.2004.04.003.S0091743504002026
    1. Schulte SJ, Meier PS, Stirling J. Dual diagnosis clients' treatment satisfaction - a systematic review. BMC Psychiatry. 2011 Apr 18;11(1):64. doi: 10.1186/1471-244x-11-64.
    1. Attkisson C, Greenfield T. The UCSF Client Satisfaction Scales: I. The Client Satisfaction Questionnaire-8. In: Maruish ME, editor. The use of psychological testing for treatment planning outcomes assessment: Instruments for adults, Volume 3, 3rd ed. Mahwah, NJ: Lawrence Erlbaum Associates Publishers; 2004. pp. 799–811.
    1. Lindquist R, Wyman JF, Talley KMC, Findorff MJ, Gross CR. Design of control-group conditions in clinical trials of behavioral interventions. J Nurs Scholarsh. 2007;39(3):214–21. doi: 10.1111/j.1547-5069.2007.00171.x.JNU171
    1. Rogers CE, Larkey LK, Keller C. A review of clinical trials of tai chi and qigong in older adults. West J Nurs Res. 2009 Mar;31(2):245–79. doi: 10.1177/0193945908327529. 31/2/245
    1. Larkey LK, Roe DJ, Smith L, Millstine D. Exploratory outcome assessment of Qigong/Tai Chi Easy on breast cancer survivors. Complement Ther Med. 2016 Dec;29:196–203. doi: 10.1016/j.ctim.2016.10.006. S0965-2299(16)30237-0
    1. Cudjoe TKM, Kotwal AA. "Social Distancing" Amid a Crisis in Social Isolation and Loneliness. J Am Geriatr Soc. 2020 Jun;68(6):E27–E29. doi: 10.1111/jgs.16527.
    1. Karayannis N, Baumann I, Sturgeon J, Melloh M, Mackey S. The Impact of Social Isolation on Pain Interference: A Longitudinal Study. Ann Behav Med. 2019 Jan 01;53(1):65–74. doi: 10.1093/abm/kay017. 4969712
    1. Guo Y, Xu M, Wei Z, Hu Q, Chen Y, Yan J, Wei Y. Beneficial Effects of in the Improvement of Health Condition, Prevention, and Treatment of Chronic Diseases: Evidence from a Systematic Review. Evid Based Complement Alternat Med. 2018;2018:3235950. doi: 10.1155/2018/3235950. doi: 10.1155/2018/3235950.
    1. Li F. Transforming traditional Tai Ji Quan techniques into integrative movement therapy- J Sport Health Sci. 2014 Mar 01;3(1):9–15. doi: 10.1016/j.jshs.2013.11.002.
    1. Fink D, Houston K. Implementing an evidence-based Tai Ji Quan program in a multicultural setting: A pilot dissemination project. Journal of Sport and Health Science. 2014 Mar;3(1):27–31. doi: 10.1016/j.jshs.2013.10.003. doi: 10.1016/j.jshs.2013.10.003.
    1. Leung J. Implementing Tai Ji Quan: Moving for Better Balance in real-world settings: Success and challenges. Journal of Sport and Health Science. 2014 Mar;3(1):34–35. doi: 10.1016/j.jshs.2013.12.001. doi: 10.1016/j.jshs.2013.12.001.
    1. Harmer P. So much research, so little application: Barriers to dissemination and practical implementation of Tai Ji Quan. J Sport Health Sci. 2014 Mar 01;3(1):16–20. doi: 10.1016/j.jshs.2013.10.005.
    1. Cherrington A, Ayala GX, Elder JP, Arredondo EM, Fouad M, Scarinci I. Recognizing the diverse roles of community health workers in the elimination of health disparities: from paid staff to volunteers. Ethn Dis. 2010;20(2):189–94.
    1. Mays AM, Kim S, Rosales K, Au T, Rosen S. The Leveraging Exercise to Age in Place (LEAP) Study: Engaging Older Adults in Community-Based Exercise Classes to Impact Loneliness and Social Isolation. Am J Geriatr Psychiatry. 2021 Aug 16;29(8):777–788. doi: 10.1016/j.jagp.2020.10.006. S1064-7481(20)30514-5
    1. Gonçalves Mário, Matos LC, Duarte L, Machado J, Greten HJ, Franconi G. Problems of scientific methodology related to placebo control in Qigong studies: A systematic review. J Bodyw Mov Ther. 2020 Oct;24(4):261–270. doi: 10.1016/j.jbmt.2020.06.035.S1360-8592(20)30114-5
    1. Park CM. Diversity, the individual, and proof of efficacy: complementary and alternative medicine in medical education. Am J Public Health. 2002 Oct;92(10):1568–72. doi: 10.2105/ajph.92.10.1568.
    1. Larkey L, Huberty J, Pedersen M, Weihs K. Qigong/Tai Chi Easy for fatigue in breast cancer survivors: Rationale and design of a randomized clinical trial. Contemp Clin Trials. 2016 Sep;50:222–8. doi: 10.1016/j.cct.2016.08.002. doi: 10.1016/j.cct.2016.08.002.S1551-7144(16)30200-2

Source: PubMed

3
Abonnieren