How to decide intervention thresholds based on FRAX in central south Chinese postmenopausal women

Zhimin Zhang, Yangna Ou, Zhifeng Sheng, Eryuan Liao, Zhimin Zhang, Yangna Ou, Zhifeng Sheng, Eryuan Liao

Abstract

The FRAX tool has been used to determine possible thresholds for therapeutic intervention; however, there are no FRAX-based intervention thresholds available for China, we proposed that the 10-year probability of major osteoporotic fracture and hip fracture of about 4.0 and 1.3%, respectively, may be acceptable intervention thresholds for central south Chinese postmenopausal women.

Figures

Fig. 1
Fig. 1
Comparison of 10-year probability of hip fracture in different FRAX models, BMI is set at 24 kg/m2

References

    1. J.A. Kanis, on behalf of the World Health Organization Scientific Group, Assessment of osteoporosis at the primary healthcare level. Technical Report. WHO Collaborating Centre, University of Sheffield, UK, (2008)
    1. Kanis JA, McClosky EV, Johansson H, Strom O, Borgstrom F, Oden A. National Osteoporosis Guideline Group, Case finding for the management of osteoporosis with FRAX®—assessment and intervention thresholds for the UK. Osteoporos. Int. 2008;19:1395–1408. doi: 10.1007/s00198-008-0712-1.
    1. Siminoski K, Leslie WD, Frame H, Hodsman A, Josse RG, Khan A, Lentle BC, Levesque J, Lyons DJ, Tarulli G, Brown JP. Recommendations for bone mineral density reporting in Canada: a shift to absolute fracture risk assessment. J Clin Densitom. 2007;10:120–123. doi: 10.1016/j.jocd.2007.01.001.
    1. Fujiwara S, Nakamura T, Orimo H, Hosoi T, Gorai I, Oden A, Johansson H, Kanis JA. Development and application of a Japanese model of the WHO fracture risk assessment tool (FRAX) Osteoporos. Int. 2008;19:429–448. doi: 10.1007/s00198-007-0544-4.
    1. Kurth AA, Pfeilschifter J. Diagnosis and treatment of postmenopausal osteoporosis and osteoporosis in men. German guidelines update 2006. Orthopade. 2007;36:683–690. doi: 10.1007/s00132-007-1106-3.
    1. Awson-Hughes B, Tosteson AN, 3rd Melton LJ, Baim S, Favus MJ, Khosla S, Lindsay RL. Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA. Osteoporos. Int. 2008;19:449–458. doi: 10.1007/s00198-008-0559-5.
    1. Siris E, Delmas PD. Assessment of 10-year absolute risk: a new paradigm with worldwide application. Osteoporos. Int. 2008;19:383–384. doi: 10.1007/s00198-008-0564-8.
    1. Kanis JA, McClosky EV, Johansson H, Oden A. Approaches to the targeting of treatment for osteoporosis. Nat. Rev. Rheumatol. 2009;5:425–431. doi: 10.1038/nrrheum.2009.139.
    1. Royal College of Physicians . Osteoporosis: Clinical Guidelines for the Prevention and Treatment. London: Royal College of Physicians; 1999.
    1. Royal College of Physicians and Bone and Tooth Society of Great Britain . Update on Pharmacological Interventions and an Algorithm for Management. London: Royal College of Physicians; 2000.
    1. Bone and Tooth Society of Great Britain . National Osteoporosis Society and Royal College of Physicians, Glucocorticoid Induced Osteoporosis: Guidelines on Prevention and Treatment. London: Royal College of Physicians; 2002.
    1. Kanis JA, Adams J, Borgström F, Cooper C, Jönsson B, Preedy D, Selby P, Compston J. The cost-effectiveness of alendronate in the management of osteoporosis. Bone. 2008;42:4–15. doi: 10.1016/j.bone.2007.10.019.
    1. Czerwinski E, Badurski JE, Marcinowska-suchowierska E, Osieleniec J. Current understanding of osteoporosis according to the position of the World Health Organization (WHO) and International Osteoporosis Foundation. Ortop. Traumatol. Rehabil. 2007;9:337–356.
    1. Tsang SW, Kung AW, Kanis JA, Johansson H, Oden A. Ten-year fracture probability in Hong Kong southern Chinese according to age and BMD femoral neck T-scores. Osteoporos. Int. 2009;20:1939–1945. doi: 10.1007/s00198-009-0906-1.
    1. Lippuner K, Johansson H, Kanis JA, Rizzoli R. Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women. Osteoporos. Int. 2009;20:1131–1140. doi: 10.1007/s00198-008-0779-8.
    1. Tosteson AN, 3rd Melton LJ, Dawson-Hughes B, Baim S, Favus MJ, Khosla S, Lindsay RL. National Osteoporosis Foundation Guide Committee, Cost-effective osteoporosis treatment thresholds: the United states perspective. Osteoporos. Int. 2008;19:437–447. doi: 10.1007/s00198-007-0550-6.
    1. National Osteoporosis Foundation (NOF) Physician’s Guide to Prevention and Treatment of Osteoporosis. Washington: National Osteoporosis Foundation; 2003.
    1. Lekamwasam S. Application of FRAX Model to Sri Lankan postmenopausal women. J Clin Densitom. 2010;13:51–55. doi: 10.1016/j.jocd.2009.09.001.
    1. Kung AW, Lee KK, Ho AY, Tang G, Luk KD. Ten-year risk of osteoporotic fractures in postmenopausal Chinese women according to clinical risk factors and BMD T-scores: a prospective study. J. Bone Miner. Res. 2007;22:1080–1087. doi: 10.1359/jbmr.070320.
    1. Kwok AW, Leung JC, Chan AY AY, Au BS, Lau EM, Yurianto H, Yuktanandana P, Yoshimura N, Muraki S, Oka H, Akune T, Leung PC. Prevalence of vertebral fracture in Asian men and women: comparison between Hong Kong, Thailand, Indonesia and Japan. Public Health. 2012;126:523–531. doi: 10.1016/j.puhe.2012.03.002.
    1. Zhang Z, Shen X, Zhang H, Li S, Zhou H, Wu X, Sheng Z, Liao E. The relationship between body composition and fracture risk using the FRAX model in central south Chinese postmenopausal women. Clin. Endocrinol. (Oxf) 2012;77:524–530. doi: 10.1111/j.1365-2265.2012.04399.x.

Source: PubMed

3
Abonnieren