The Efficacy of a Brief, Altruism-Eliciting Video Intervention in Enhancing COVID-19 Vaccination Intentions Among a Population-Based Sample of Younger Adults: Randomized Controlled Trial

Abstract

Background: High COVID-19 vaccine uptake is crucial to containing the pandemic and reducing hospitalizations and deaths. Younger adults (aged 20-39 years) have demonstrated lower levels of vaccine uptake compared to older adults, while being more likely to transmit the virus due to a higher number of social contacts. Consequently, this age group has been identified by public health authorities as a key target for vaccine uptake. Previous research has demonstrated that altruistic messaging and motivation is associated with vaccine acceptance.

Objective: This study had 2 objectives: (1) to evaluate the within-group efficacy of an altruism-eliciting short, animated video intervention in increasing COVID-19 vaccination intentions amongst unvaccinated Canadian younger adults and (2) to examine the video's efficacy compared to a text-based intervention focused exclusively on non-vaccine-related COVID-19 preventive health measures.

Methods: Using a web-based survey in a pre-post randomized control trial (RCT) design, we recruited Canadians aged 20-39 years who were not yet vaccinated against COVID-19 and randomized them in a 1:1 ratio to receive either the video intervention or an active text control. The video intervention was developed by our team in collaboration with a digital media company. The measurement of COVID-19 vaccination intentions before and after completing their assigned intervention was informed by the multistage Precaution Adoption Process Model (PAPM). The McNemar chi-square test was performed to evaluate within-group changes of vaccine intentions. Exact tests of symmetry using pairwise McNemar tests were applied to evaluate changes in multistaged intentions. Between-group vaccine intentions were assessed using the Pearson chi-square test postintervention.

Results: Analyses were performed on 1373 participants (n=686, 50%, in the video arm, n=687, 50%, in the text arm). Within-group results for the video intervention arm showed that there was a significant change in the intention to receive the vaccine (χ21=20.55, P<.001). The between-group difference in postintervention intentions (χ23=1.70, P=.64) was not significant. When administered the video intervention, we found that participants who had not thought about or were undecided about receiving a COVID-19 vaccine were more amenable to change than participants who had already decided not to vaccinate.

Conclusions: Although the video intervention was limited in its effect on those who had firmly decided not to vaccinate, our study demonstrates that prosocial and altruistic messages could increase COVID-19 vaccine uptake, especially when targeted to younger adults who are undecided or unengaged regarding vaccination. This might indicate that altruistic messaging provides a "push" for those who are tentative toward, or removed from, the decision to receive the vaccine. The results of our study could also be applied to more current COVID-19 vaccination recommendations (eg, booster shots) and for other vaccine-preventable diseases.

Trial registration: ClinicalTrials.gov NCT04960228; https://ichgcp.net/clinical-trials-registry/NCT04960228.

Keywords: COVID-19; altruism; digital health; digital intervention; health information; health intervention; health promotion; online health; prosocial motives; public health; randomized controlled trial; vaccination; vaccine hesitancy; video intervention; web survey; younger adults; youth.

Conflict of interest statement

Conflicts of Interest: Within the past 5 years, GZ has served as a consultant to Merck (regarding human papillomavirus [HPV] vaccination), Pfizer (regarding meningococcal vaccination), and Sanofi Pasteur (regarding adolescent vaccination). GZ also has served on advisory boards for Merck (regarding HPV vaccination) and Moderna (regarding COVID-19 vaccination). The other authors declare no conflicts of interest.

©Patricia Zhu, Ovidiu Tatar, Gabrielle Griffin-Mathieu, Samara Perez, Ben Haward, Gregory Zimet, Matthew Tunis, Ève Dubé, Zeev Rosberger. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 30.05.2022.

Figures

Figure 1

CONSORT diagram. CONSORT: Consolidated Standards of Reporting Trials; PAPM: Precaution Adoption Process Model.

Figure 2

PAPM stage transitions from T1 (baseline) to T2 (postintervention) in the video group (N=686). OR: odds ratio; PAPM: Precaution Adoption Process Model. Green arrows show significant transitions toward increased and red arrows toward decreased vaccination intentions. Gray arrows show nonsignificant transitions between stages..

Figure 3

PAPM stage transitions from T1 (baseline) to T2 (postintervention) in the text group (N=687). OR: odds ratio; PAPM: Precaution Adoption Process Model. Green arrows show significant transitions toward increased and red arrows toward decreased vaccination intentions. Gray arrows show nonsignificant transitions between stages.