Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants
J L Wynn, L Li, C M Cotten, D L Phelps, S Shankaran, R N Goldberg, W A Carlo, K Van Meurs, A Das, B R Vohr, R D Higgins, B J Stoll, C T D'Angio, J L Wynn, L Li, C M Cotten, D L Phelps, S Shankaran, R N Goldberg, W A Carlo, K Van Meurs, A Das, B R Vohr, R D Higgins, B J Stoll, C T D'Angio
Abstract
Objective: Sepsis in older children and adults modifies immune system function. We compared serotype-specific antibody responses to heptavalent pneumococcal conjugate vaccine (PCV7) in very low birth weight infants (<1500 g,VLBWs) with and without blood stream infection (BSI) during their birth hospitalization.
Study design: Retrospective analysis of prospectively collected data for the Neonatal Research Network study of PCV7 responses among VLBWs. Infants received PCV7 at 2, 4 and 6 months after birth with blood drawn 4 to 6 weeks after third dose. Serotype antibodies were compared between infants with or without a history of BSI. Regression models were constructed with BW groups and other confounding factors identified in the primary study.
Result: In all, 244 infants completed the vaccine series and had serum antibody available; 82 had BSI. After adjustment, BSI was not associated with reduced odds of serum antibody 0.35 μg ml(-1).
Conclusion: BSI was not associated with reduced odds of World Health Organization-defined protective PCV7 responses in VLBWs.
Conflict of interest statement
All authors declare no conflict of interest.
Conflict of interest statement
All authors declare no conflict of interest.
Source: PubMed