Capacity-building and clinical competence in infectious disease in Uganda: a mixed-design study with pre/post and cluster-randomized trial components

Marcia R Weaver, Ian Crozier, Simon Eleku, Gyaviira Makanga, Lydia Mpanga Sebuyira, Janepher Nyakake, MaryLou Thompson, Kelly Willis, Marcia R Weaver, Ian Crozier, Simon Eleku, Gyaviira Makanga, Lydia Mpanga Sebuyira, Janepher Nyakake, MaryLou Thompson, Kelly Willis

Abstract

Trial design: Best practices for training mid-level practitioners (MLPs) to improve global health-services are not well-characterized. Two hypotheses were: 1) Integrated Management of Infectious Disease (IMID) training would improve clinical competence as tested with a single arm, pre-post design, and 2) on-site support (OSS) would yield additional improvements as tested with a cluster-randomized trial.

Methods: Thirty-six Ugandan health facilities (randomized 1∶1 to parallel OSS and control arms) enrolled two MLPs each. All MLPs participated in IMID (3-week core course, two 1-week boost sessions, distance learning). After the 3-week course, OSS-arm trainees participated in monthly OSS. Twelve written case scenarios tested clinical competencies in HIV/AIDS, tuberculosis, malaria, and other infectious diseases. Each participant completed different randomly-assigned blocks of four scenarios before IMID (t0), after 3-week course (t1), and after second boost course (t2, 24 weeks after t1). Scoring guides were harmonized with IMID content and Ugandan national policy. Score analyses used a linear mixed-effects model. The primary outcome measure was longitudinal change in scenario scores.

Results: Scores were available for 856 scenarios. Mean correct scores at t0, t1, and t2 were 39.3%, 49.1%, and 49.6%, respectively. Mean score increases (95% CI, p-value) for t0-t1 (pre-post period) and t1-t2 (parallel-arm period) were 12.1 ((9.6, 14.6), p<0.001) and -0.6 ((-3.1, +1.9), p = 0.647) percent for OSS arm and 7.5 ((5.0, 10.0), p<0.001) and 1.6 ((-1.0, +4.1), p = 0.225) for control arm. The estimated mean difference in t1 to t2 score change, comparing arm A (participated in OSS) vs. arm B was -2.2 ((-5.8, +1.4), p = 0.237). From t0-t2, mean scores increased for all 12 scenarios.

Conclusions: Clinical competence increased significantly after a 3-week core course; improvement persisted for 24 weeks. No additional impact of OSS was observed. Data on clinical practice, facility-level performance and health outcomes will complete assessment of overall impact of IMID and OSS.

Trial registration: ClinicalTrials.gov NCT01190540.

Conflict of interest statement

Competing Interests: Lydia Mpanga Sebuyira states that under her leadership, the IDI Training Department received funds from various commercial enterprises and public agency sources, none of which she believes presented any conflicts of interest. Kelly Willis states that Accordia Global Health Foundation received funds from commercial and non-profit enterprises, which she does not believe were conflicts of interest for her or her staff. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Figures

Figure 1. Inclusion and exclusion criteria for…
Figure 1. Inclusion and exclusion criteria for health facilities and mid-level practitioners.
Figure 2. Flow diagram of mid-level practitioners…
Figure 2. Flow diagram of mid-level practitioners who attended the Integrated Management of Infectious Diseases course.
The figure shows the selection and random allocation of health facilities to two arms. Participants in arm A attended the Integrated Management of Infectious Disease (IMID) training program and On-Site Support. Participants in arm B attended IMID.
Figure 3. Allocation of case scenarios across…
Figure 3. Allocation of case scenarios across testing points.
The 72 IDCAP participants (36 from arm A, 36 from arm B) were randomly assigned to three groups, which contained 12 participants from each arm. The 12 clinical case scenarios were distributed across three, 4-scenario blocks (A, B, and C), and each group was assigned to a different sequence of blocks.

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