Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men
J T Salonen, K Nyyssönen, T P Tuomainen, P H Mäenpää, H Korpela, G A Kaplan, J Lynch, S P Helmrich, R Salonen, J T Salonen, K Nyyssönen, T P Tuomainen, P H Mäenpää, H Korpela, G A Kaplan, J Lynch, S P Helmrich, R Salonen
Abstract
Objective: To investigate whether low vitamin E status is a risk factor for incident non-insulin dependent diabetes mellitus.
Design: Population based follow up study with diabetes assessed at baseline and at four years.
Setting: Eastern Finland.
Subjects: Random sample of 944 men aged 42-60 who had no diabetes at the baseline examination.
Intervention: Oral glucose tolerance test at four year follow up.
Main outcome measures: A man was defined diabetic if he had either (a) a fasting blood glucose concentration > or = 6.7 mmol/l, or (b) a blood glucose concentration > or = 10.0 mmol/l two hours after a glucose load, or (c) a clinical diagnosis of diabetes with either dietary, oral, or insulin treatment.
Results: 45 men developed diabetes during the follow up period. In a multivariate logistic regression model including the strongest predictors of diabetes, a low lipid standardised plasma vitamin E (below median) concentration was associated with a 3.9-fold (95% confidence interval 1.8-fold to 8.6-fold) risk of incident diabetes. A decrement of 1 mumol/l of uncategorised unstandardised vitamin E concentration was associated with an increment of 22% in the risk of diabetes when allowing for the strongest other risk factors as well as serum low density lipoprotein cholesterol and triglyceride concentrations.
Conclusions: There was a strong independent association between low vitamin E status before follow up and an excess risk of diabetes at four years. This supports the theory that free radical stress has a role in the causation of non-insulin dependent diabetes mellitus.
References
- Diabetologia. 1993 Nov;36(11):1212-3
- Br Med Bull. 1993 Jul;49(3):679-99
- Diabete Metab. 1994 Jan-Feb;20(1):3-14
- Biochem Med. 1979 Feb;21(1):104-7
- J Chromatogr. 1979 Mar 1;162(3):408-13
- Biochem Med. 1981 Jun;25(3):373-8
- Atherosclerosis. 1988 Mar;70(1-2):155-60
- Ann Clin Res. 1988;20(1-2):46-50
- BMJ. 1990 Nov 17;301(6761):1121-3
- Diabetes Res. 1990 Feb;13(2):67-73
- Am J Epidemiol. 1991 May 1;133(9):850-7
- Circulation. 1991 Jul;84(1):129-39
- Int J Epidemiol. 1991 Dec;20(4):1010-7
- J Lab Clin Med. 1992 May;119(5):503-7
- Int J Epidemiol. 1992 Jun;21(3):467-72
- Behav Med. 1992 Fall;18(3):121-6
- Diabetes Res Clin Pract. 1992 Oct;18(1):11-6
- EXS. 1992;62:342-52
- Clin Chim Acta. 1993 Feb 28;214(2):227-34
- Am J Clin Nutr. 1993 May;57(5):650-6
- Br Med Bull. 1993 Jul;49(3):642-52
- Diabetes. 1994 Aug;43(8):1010-4
Source: PubMed