Glycaemic control for people with type 2 diabetes in Saudi Arabia - an urgent need for a review of management plan

Mohammed J Alramadan, Dianna J Magliano, Turky H Almigbal, Mohammed Ali Batais, Afsana Afroz, Hesham J Alramadhan, Waad Faozi Mahfoud, Adel Mehmas Alragas, Baki Billah, Mohammed J Alramadan, Dianna J Magliano, Turky H Almigbal, Mohammed Ali Batais, Afsana Afroz, Hesham J Alramadhan, Waad Faozi Mahfoud, Adel Mehmas Alragas, Baki Billah

Abstract

Background: The aim of this study was to assess inadequate glycaemic control and its associated factors among people with type 2 diabetes in Saudi Arabia.

Methods: A cross-sectional study design was used. Adults with type 2 diabetes attending diabetes centres in Riyadh, Hofuf and Jeddah cities were interviewed and their anthropometrics were measured. Their medical records were also reviewed to collect information related to recent lab tests, medications, and documented comorbidities. Multivariable logistic regression were used for data analysis.

Results: A total of 1111 participants were recruited in the study. Mean age was 57.6 (±11.1) years, 65.2% of the participants were females, and mean HbA1c was 8.5 ± 1.9%. About three-fourths of participants had inadequate glycaemic control (≥ 7%). Multivariable analysis showed that age ≤ 60 years, longer duration of diabetes, living in a remote location, low household income, low intake of fruits and vegetable, low level of physical activity, lack of knowledge about haemoglobin A1c, high waist-hip ratio, low adherence to medication, and using injectable medications were independent risk factors for inadequate glycaemic control.

Conclusions: Inadequate glycaemic control is prevalent among people with type 2 diabetes in Saudi Arabia. In order to improve glycaemic control diabetes management plan should aim at controlling the modifiable risk factors which include low intake of fruits and vegetable, low level of physical activity, lack of knowledge about haemoglobin A1c, high waist-hip ratio, and low adherence to medications.

Keywords: Diabetes; Glycaemic control; Saudi Arabia.

Conflict of interest statement

Ethics approval and consent to participate

Ethical approval was obtained from the Monash University Human Research Ethics Committee in Australia and the Research Ethics Committee of the Ministry of Health in Saudi Arabia. Written informed consent was obtained from all the study participants.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Adjusted association between risk factors and inadequate (HbA1c ≥ 7%) and very poor (HbA1c ≥ 9%) glycaemic control. Variables introduced in the multivariable analysis were age, gender, education level, location of residence, work status, income, region, intake of fruits and vegetables, physical activity, duration of diabetes, treatment modality, glucometer use frequency, hypoglycaemia, follow-up location, adherence to medication, awareness of HbA1c, BMI, waist-hip ratio, macrovascular complications, microvascular complications and dyslipidaemia
Fig. 2
Fig. 2
Adjusted association between risk factors and inadequate control (HbA1c ≥ 7%) by the modality of treatment. Variables introduced in the multivariable analysis were age, gender, education level, location of residence, work status, income, region, intake of fruits and vegetables, physical activity, duration of diabetes, treatment modality, glucometer use frequency, hypoglycaemia, follow-up location, adherence to medication, awareness of HbA1c, BMI, waist-hip ratio, macrovascular complications, microvascular complications and dyslipidaemia

References

    1. El Bcheraoui C, Basulaiman M, Tuffaha M, Daoud F, Robinson M, Jaber S, et al. Status of the diabetes epidemic in the Kingdom of Saudi Arabia, 2013. Int J Pub Health. 2014;59(6):1011–1021. doi: 10.1007/s00038-014-0612-4.
    1. Cho NH, Kirigia J, Mbanya JC, Ogurstova K, Guariguata L, Rathmann W, et al. IDF DIABETES ATLAS eighth edition 2017. Int Diabet Fed. 2017:1–147.
    1. Al-Quwaidhi AJ, Pearce MS, Sobngwi E, Critchley JA, O’Flaherty M. Comparison of type 2 diabetes prevalence estimates in Saudi Arabia from a validated Markov model against the international diabetes federation and other modelling studies. Diabetes Res Clin Pract. 2014;103(3):496–503. doi: 10.1016/j.diabres.2013.12.036.
    1. American Diabetes Association. American Diabetes Association Standards of Medical Care in Diabetes-2017. The Journal of Clinical and Applied Research and Education. 2017;40.
    1. Collaboration ERF Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;2011(364):829–841. doi: 10.1056/NEJMoa1008862.
    1. Klein R, Klein BE, Moss SE. Relation of glycemic control to diabetic microvascular complications in diabetes mellitus. Ann Intern Med. 1996;124(1_Part_2):90–96. doi: 10.7326/0003-4819-124-1_Part_2-199601011-00003.
    1. Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, Cohen RM, et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet. 2010;376(9739):419–430. doi: 10.1016/S0140-6736(10)60576-4.
    1. Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360(2):129–139. doi: 10.1056/NEJMoa0808431.
    1. Al-Nuaim AR, Mirdad S, Al-Rubeaan K, Al-Mazrou Y, Al-Attas O, Al-Daghari N. Pattern and factors associated with glycemic control of Saudi diabetic patients. Ann Saudi Med. 1998;18(2):109–112. doi: 10.5144/0256-4947.1998.109.
    1. Al-Hayek AA, Robert AA, Alzaid AA, Nusair HM, Zbaidi NS, Al-Eithan MH, et al. Association between diabetes self-care, medication adherence, anxiety, depression, and glycemic control in type 2 diabetes. Saudi Med J. 2012;33(6):681–683.
    1. Alsulaiman TA, Al-Ajmi HA, Al-Qahtani SM, Fadlallah IM, Nawar NE, Shukerallah RE, et al. Control of type 2 diabetes in king Abdulaziz Housing City (Iskan) population, Saudi Arabia. J Family Community Med. 2016;23(1):1. doi: 10.4103/2230-8229.172221.
    1. Almutairi MA, Said SM, Zainuddin H. Predictors of poor glycemic control among type two diabetic patients. Am J Med Medical Sci. 2013;3(2):17–21.
    1. Alzaheb RA, Altemani AH. The prevalence and determinants of poor glycemic control among adults with type 2 diabetes mellitus in Saudi Arabia. Diabetes Metab Syndr Obes. 2018;11:15. doi: 10.2147/DMSO.S156214.
    1. Alwakeel J, Sulimani R, Al-Asaad H, Al-Harbi A, Tarif N, Al-Suwaida A, et al. Diabetes complications in 1952 type 2 diabetes mellitus patients managed in a single institution. Ann Saudi Med. 2008;28(4):260. doi: 10.4103/0256-4947.51702.
    1. Al Ghamdi AH, Rabiu M, Hajar S, Yorston D, Kuper H, Polack S. Rapid assessment of avoidable blindness and diabetic retinopathy in Taif, Saudi Arabia. Br J Ophthalmol. 2012;96(9):1168–1172. doi: 10.1136/bjophthalmol-2012-301874.
    1. Halawa MR, Karawagh A, Zeidan A, Mahmoud A-E-DH, Sakr M, Hegazy A. Prevalence of painful diabetic peripheral neuropathy among patients suffering from diabetes mellitus in Saudi Arabia. Curr Med Res Opin. 2010;26(2):337–343. doi: 10.1185/03007990903471940.
    1. Binhemd TA. Diabetes mellitus: knowledge, attitude, practice and their relation to diabetes control in female diabetics. Ann Saudi Med. 1992;12(3):247–251. doi: 10.5144/0256-4947.1992.247.
    1. Sanal T, Nair N, Adhikari P. Factors associated with poor control of type 2 diabetes mellitus: a systematic review and meta-analysis. J Diabetol. 2011;3(1):1–10.
    1. Alramadan MJ, Afroz A, Batais MA, Almigbal TH, Alhamrani HA, Albaloshi A, et al. A study protocol to assess the determinants of Glycaemic control, complications and health related quality of life for people with type 2 diabetes in Saudi Arabia. J Health Edu Res Develop. 2017;5(2):1–6. doi: 10.4172/2380-5439.1000219.
    1. Al-Turki YA. Blood sugar control, ophthalmology referral and creatinine level among adult diabetic patients in primary health care, Riyadh, Saudi Arabia. Saudi Med J. 2002;23(11):1332–1334.
    1. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–381. doi: 10.1016/j.jbi.2008.08.010.
    1. Armstrong T, Bull F. Development of the world health organization global physical activity questionnaire (GPAQ) J Public Health. 2006;14(2):66–70. doi: 10.1007/s10389-006-0024-x.
    1. England CY, Thompson JL, Jago R, Cooper AR, Andrews RC. Development of a brief, reliable and valid diet assessment tool for impaired glucose tolerance and diabetes: the UK diabetes and diet questionnaire. Public Health Nutr. 2017;20(2):191–199. doi: 10.1017/S1368980016002275.
    1. Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24(1):67–74. doi: 10.1097/00005650-198601000-00007.
    1. Moghtaderi A, Bakhshipour A, Rashidi H. Validation of Michigan neuropathy screening instrument for diabetic peripheral neuropathy. Clin Neurol Neurosurg. 2006;108(5):477–481. doi: 10.1016/j.clineuro.2005.08.003.
    1. Skapinakis P. The 2-item Generalized Anxiety Disorder scale had high sensitivity and specificity for detecting GAD in primary care. Evid Based Med. 2007;12(5):149. doi: 10.1136/ebm.12.5.149.
    1. Kroenke K, Spitzer RL, Williams JB. The patient health Questionnaire-2: validity of a two-item depression screener. Med Care. 2003;41(11):1284–1292. doi: 10.1097/01.MLR.0000093487.78664.3C.
    1. Storey JE, Rowland JT, Conforti DA, Dickson HG. The Rowland universal dementia assessment scale (RUDAS): a multicultural cognitive assessment scale. Int Psychogeriatr. 2004;16(01):13–31. doi: 10.1017/S1041610204000043.
    1. Oglesby AK, Secnik K, Barron J, Al-Zakwani I, Lage MJ. The association between diabetes related medical costs and glycemic control: a retrospective analysis. Cost Eff Resour Alloc. 2006;4(1):1. doi: 10.1186/1478-7547-4-1.
    1. Al-Lawati JA, Barakat NM, Al-Lawati AM, Mohammed AJ. Optimal cut-points for body mass index, waist circumference and waist-to-hip ratio using the Framingham coronary heart disease risk score in an Arab population of the Middle East. Diab Vasc Dis Res. 2008;5(4):304–309. doi: 10.3132/dvdr.2008.044.
    1. Deed G, Ackermann E, Newman R, Audehm R, Arthur I, Barlow J, et al. General Practice Management of Type 2 Diabetes: 2014–15: Royal Australian College of General Practitioners (RACGP); 2014.
    1. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–612. doi: 10.7326/0003-4819-150-9-200905050-00006.
    1. Grams ME, Rebholz CM, McMahon B, Whelton S, Ballew SH, Selvin E, et al. Identification of incident CKD stage 3 in research studies. Am J Kidney Dis. 2014;64(2):214–221. doi: 10.1053/j.ajkd.2014.02.021.
    1. Billah B, Huq MM, Smith JA, Sufi F, Tran L, Shardey GC, et al. AusSCORE II in predicting 30-day mortality after isolated coronary artery bypass grafting in Australia and New Zealand. J Thorac Cardiovasc Surg. 2014;148(5):1850–1855. doi: 10.1016/j.jtcvs.2014.02.027.
    1. Al Baghli N, Al Turki K, Al Ghamdi A, El Zubaier A, Al Ameer M, Al BF. Control of diabetes mellitus in the eastern province of Saudi Arabia: results of screening campaign. 2010.
    1. Al-Rasheedi AAS. The role of educational level in glycemic control among patients with type II diabetes mellitus. Int J Health Sci. 2014;8(2):177. doi: 10.12816/0006084.
    1. Al Balushi KA, Al-Haddabi M, Al-Zakwani I, Al Z'a M. Glycemic control among patients with type 2 diabetes at a primary health care center in Oman. Prim Care Diabetes. 2014;8(3):239–243. doi: 10.1016/j.pcd.2014.01.003.
    1. Al-Ibrahim AAH. Factors associated with compliance to diabetes self-care behaviors and glycemic control among Kuwaiti people with type 2 diabetes. 2012.
    1. Al-Kaabi J, Al-Maskari F, Saadi H, Afandi B, Parkar H, Nagelkerke N. Assessment of dietary practice among diabetic patients in the United Arab Emirates. Rev Diabet Stud. 2008;5(2):110–115. doi: 10.1900/RDS.2008.5.110.
    1. Al-Hamdan N, Kutbi A, Choudhry A, Nooh R, Shoukri M, Mujib S. WHO stepwise approach to NCD surveillance country-specific standard report Saudi Arabia. In: Organization WH, editor. WHO Stepwise Approach. Geneva: WHO; 2005.
    1. Al-Nozha MM, Al-Hazzaa HM, Arafah MR, Al-Khadra A, Al-Mazrou YY, Al-Maatouq MA, et al. Prevalence of physical activity and inactivity among Saudis aged 30-70 years. A population-based cross-sectional study. Saudi Med J. 2007;28(4):559–568.
    1. Al Othaimeen A, Al Nozha M, Osman A. Obesity: an emerging problem in Saudi Arabia. Analysis of data from the National Nutrition Survey. East Mediterr Health J. 2007;13(2):441–448.
    1. Al-Nozha MM, Al-Maatouq MA, Al-Mazrou YY, Al-Harthi SS, Arafah MR, Khalil MZ, et al. Diabetes mellitus in Saudi Arabia. Saudi Med J. 2004;25(11):1603–1610.
    1. Alqurashi K, Aljabri K, Bokhari S. Prevalence of diabetes mellitus in a Saudi community. Ann Saudi Med. 2011;31(1):19. doi: 10.5144/0256-4947.2011.19.
    1. Shamsi N, Shehab Z, AlNahash Z, AlMuhanadi S, Al-Nasir F. Factors influencing dietary practice among type 2 diabetics. Bahrain Med Bull. 2013;35:3. doi: 10.12816/0000752.
    1. Tang YH, Pang S, Chan MF, Yeung GS, Yeung VT. Health literacy, complication awareness, and diabetic control in patients with type 2 diabetes mellitus. J Adv Nurs. 2008;62(1):74–83. doi: 10.1111/j.1365-2648.2007.04526.x.
    1. Cagliero E, Levina EV, Nathan DM. Immediate feedback of HbA1c levels improves glycemic control in type 1 and insulin-treated type 2 diabetic patients. Diabetes Care. 1999;22(11):1785–1789. doi: 10.2337/diacare.22.11.1785.
    1. Levetan CS, Dawn KR, Robbins DC, Ratner RE. Impact of computer-generated personalized goals on HbA1c. Diabetes Care. 2002;25(1):2–8. doi: 10.2337/diacare.25.1.2.
    1. Al-Lawati JA, Barakat MN, Al-Maskari M, Elsayed MK, Al-Lawati AM, Mohammed AJ. HbA1c levels among primary healthcare patients with type 2 diabetes mellitus in Oman. Oman Med J. 2012;27(6):465–470. doi: 10.5001/omj.2012.111.
    1. D’Souza MS, Karkada SN, Hanrahan NP, Venkatesaperumal R, Amirtharaj A. Do perceptions of empowerment affect glycemic control and self-care among adults with type 2 diabetes? Glob J Health Sci. 2015;7(5):80–90.
    1. McBrien K, Manns B, Hemmelgarn B, Weaver R, Edwards A, Ivers N, et al. The association between sociodemographic and clinical characteristics and poor glycaemic control: a longitudinal cohort study. Diabet Med. 2016;33(11):1499–1507. doi: 10.1111/dme.13023.
    1. Alramadan MJ, Afroz A, Hussain SM, Batais MA, Almigbal TH, Al-Humrani HA, et al. Patient-related determinants of Glycaemic control in people with type 2 diabetes in the Gulf cooperation council countries: a systematic review. J Diabet Res. 2018;2018:9389265. doi: 10.1155/2018/9389265.
    1. Drewelow E, Wollny A, Pentzek M, Immecke J, Lambrecht S, Wilm S, et al. Improvement of primary health care of patients with poorly regulated diabetes mellitus type 2 using shared decision-making–the DEBATE trial. BMC Fam Pract. 2012;13(1):88. doi: 10.1186/1471-2296-13-88.
    1. Chuang L-M, Soegondo S, Soewondo P, Young-Seol K, Mohamed M, Dalisay E, et al. Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia. Diabetes Res Clin Pract. 2006;71(2):146–155. doi: 10.1016/j.diabres.2005.05.007.
    1. Hsieh S, Yoshinaga H. Abdominal fat distribution and coronary heart disease risk factors in men-waist/height ratio as a simple and useful predictor. Int J Obes Relat Metab Disord. 1995;19(8):585–589.
    1. Eberhardt MS, Lackland DT, Wheeler FC, German RR, Teutsch SM. Is race related to glycemic control? An assessment of glycosylated hemoglobin in two South Carolina communities. J Clin Epidemiol. 1994;47(10):1181–1189. doi: 10.1016/0895-4356(94)90105-8.
    1. Czernichow S, Kengne A-P, Huxley RR, Batty GD, De Galan B, Grobbee D, et al. Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. Eur J Cardiovasc Prev Rehabil. 2011;18(2):312–319. doi: 10.1097/HJR.0b013e32833c1aa3.
    1. Astrup A, Finer N. Redefining type 2 diabetes:‘diabesity’or ‘obesity dependent diabetes mellitus’? Obes Rev. 2000;1(2):57–59. doi: 10.1046/j.1467-789x.2000.00013.x.
    1. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of diabetes. Diabetes Care. 2009;32(1):193–203. doi: 10.2337/dc08-9025.
    1. Peyrot M, Barnett A, Meneghini L, Schumm-Draeger PM. Insulin adherence behaviours and barriers in the multinational global attitudes of patients and physicians in insulin therapy study. Diabet Med. 2012;29(5):682–689. doi: 10.1111/j.1464-5491.2012.03605.x.
    1. Davies M. The reality of glycaemic control in insulin treated diabetes: defining the clinical challenges. Int J Obes. 2004;28:S14–S22. doi: 10.1038/sj.ijo.0802745.
    1. Brown AF, Ettner SL, Piette J, Weinberger M, Gregg E, Shapiro MF, et al. Socioeconomic position and health among persons with diabetes mellitus: a conceptual framework and review of the literature. Epidemiol Rev. 2004;26(1):63–77. doi: 10.1093/epirev/mxh002.
    1. Davis RE, Morrissey M, Peters JR, Wittrup-Jensen K, Kennedy-Martin T, Currie CJ. Impact of hypoglycaemia on quality of life and productivity in type 1 and type 2 diabetes. Curr Med Res Opin. 2005;21(9):1477–1483. doi: 10.1185/030079905X61929.
    1. Bonds DE, Miller ME, Bergenstal RM, Buse JB, Byington RP, Cutler JA, et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ. 2010;340:b4909. doi: 10.1136/bmj.b4909.
    1. Seaquist ER, Anderson J, Childs B, Cryer P, Dagogo-Jack S, Fish L, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. J Clin Endocrinol Metabol. 2013;98(5):1845–1859. doi: 10.1210/jc.2012-4127.

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