Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures

Gregory D M Potter, Debra J Skene, Josephine Arendt, Janet E Cade, Peter J Grant, Laura J Hardie, Gregory D M Potter, Debra J Skene, Josephine Arendt, Janet E Cade, Peter J Grant, Laura J Hardie

Abstract

Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large proportion of the world's population is at increased risk of environmentally driven circadian rhythm and sleep disruption, and a minority of individuals are also genetically predisposed to circadian misalignment and sleep disorders. The consequences of disruption to the circadian system and sleep are profound and include myriad metabolic ramifications, some of which may be compounded by adverse effects on dietary choices. If not addressed, the deleterious effects of such disruption will continue to cause widespread health problems; therefore, implementation of the numerous behavioral and pharmaceutical interventions that can help restore circadian system alignment and enhance sleep will be important.

Figures

Figure 1.
Figure 1.
Temporal control of physiology. Light exposure provides the primary time cue for the central clock in the suprachiasmatic nuclei (SCN) of the hypothalamus and suppresses melatonin synthesis by the pineal gland. Artificial light exposure at night can therefore disrupt the SCN clock and melatonin rhythm. As a diurnal species, melatonin is hypnogenic in humans, although a recent prospective study of pinealectomy demonstrated that endogenous melatonin may not have a strong regulatory role in sleep (42). The sleep/wake cycle has been effectively simulated by a two-process model in which a circadian process (C) influences wakefulness and interacts with a sleep-promoting process (S) that accumulates during wakefulness. Within the hypothalamus—a nodal point of body temperature regulation—the SCN influences the circadian rhythm of body temperature, a key synchronizer of clocks in peripheral tissues. The use of thermostats can obviate daily oscillations in temperature, which could perhaps influence some circadian rhythms. In addition to temperature mechanisms, the SCN influences clocks in peripheral tissues through neural signals communicated via the autonomic nervous system (ANS), as well as the timely secretion of signaling factors such as prokineticin 2. Hypothalamic-pituitary-peripheral organ axes are important to hormonal regulation of the circadian system. For example, corticotropin-releasing hormone (CRH) enters the portal system through the median eminence (ME) of the hypothalamus and stimulates the secretion of adrenocorticotropic hormone (ACTH) by the anterior pituitary gland. ACTH then regulates adrenal cortex production of cortisol, a hormone with a robust circadian oscillation and important synchronizing effects in many peripheral clocks. The timing of metabolic processes in peripheral clocks is also modified by nutritional status, and peripheral clocks relay metabolic information back to the hypothalamus through the ME. Today, around-the-clock access to food can distort the clear feeding/fasting cycles that typified much of our history.
Figure 2.
Figure 2.
Mechanisms linking circadian system and sleep disruption to hyperglycemia, insulin resistance, and obesity. With further research, mechanisms that are currently listed as distinct may prove to be common.

References

    1. Halberg F. Physiologic 24-hour periodicity; general and procedural considerations with reference to the adrenal cycle [in German]. Int Z Vitaminforsch Beih. 1959;10:225–296.
    1. Pittendrigh CS. On temperature independence in the clock system controlling emergence time in Drosophila. Proc Natl Acad Sci USA. 1954;40(10):1018–1029.
    1. Aschoff J, Klotter K, Wever RA. Circadian clocks. In: Aschoff J, ed. Proceedings of the Feldafing Summer School, September 1964 Amsterdam, The Netherlands: North Holland Publishing Co.; 1965.
    1. Czeisler CA, Duffy JF, Shanahan TL, et al. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science. 1999;284(5423):2177–2181.
    1. Middleton B, Arendt J, Stone BM. Human circadian rhythms in constant dim light (8 lux) with knowledge of clock time. J Sleep Res. 1996;5(2):69–76.
    1. Folkard S. Do permanent night workers show circadian adjustment? A review based on the endogenous melatonin rhythm. Chronobiol Int. 2008;25(2):215–224.
    1. Arendt J, Middleton B, Williams P, Francis G, Luke C. Sleep and circadian phase in a ship's crew. J Biol Rhythms. 2006;21(3):214–221.
    1. Axelsson J, Akerstedt T, Kecklund G, Lowden A. Tolerance to shift work-how does it relate to sleep and wakefulness? Int Arch Occup Environ Health. 2004;77(2):121–129.
    1. Arendt J. Shift work: coping with the biological clock. Occup Med (Lond). 2010;60(1):10–20.
    1. Knutsson A, Bøggild H. Gastrointestinal disorders among shift workers. Scand J Work Environ Health. 2010;36(2):85–95.
    1. Wang F, Yeung KL, Chan WC, et al. A meta-analysis on dose-response relationship between night shift work and the risk of breast cancer. Ann Oncol. 2013;24(11):2724–2732.
    1. Wang F, Zhang L, Zhang Y, et al. Meta-analysis on night shift work and risk of metabolic syndrome. Obes Rev. 2014;15(9):709–720.
    1. Schiavo-Cardozo D, Lima MM, Pareja JC, Geloneze B. Appetite-regulating hormones from the upper gut: disrupted control of xenin and ghrelin in night workers. Clin Endocrinol (Oxf). 2013;79(6):807–811.
    1. Parent-Thirion A, Vermeylen G, Lyly-Yrjänäinen Maija, Biletta I, Cabrita J. Fifth European Working Conditions Survey–Overview Report. Dublin, Ireland: European Foundation for the Improvement of Living and Working Conditions; 2012;1–160.
    1. Bureau of Labor Statistics. Workers on flexible and shift schedules in May 2004. Washington, DC: US Department of Labor; 2005.
    1. Hammer GP, Auvinen A, De Stavola BL, et al. Mortality from cancer and other causes in commercial airline crews: a joint analysis of cohorts from 10 countries. Occup Environ Med. 2014;71(5):313–322.
    1. Annual Review 2013. In: Program of the 69th Annual General Meeting of the International Air Transport Association; June 2013; Cape Town, South Africa.
    1. Roenneberg T, Allebrandt KV, Merrow M, Vetter C. Social jetlag and obesity. Curr Biol. 2012;22(10):939–943.
    1. Wittmann M, Dinich J, Merrow M, Roenneberg T. Social jetlag: misalignment of biological and social time. Chronobiol Int. 2006;23(1–2):497–509.
    1. Kim M, Sasai H, Kojima N, Kim H. Objectively measured night-to-night sleep variations are associated with body composition in very elderly women. J Sleep Res. 2015;24(6):639–647.
    1. Wong PM, Hasler BP, Kamarck TW, Muldoon MF, Manuck SB. Social jetlag, chronotype, and cardiometabolic risk. J Clin Endocrinol Metab. 2015;100(12):4612–4620.
    1. Taylor BJ, Matthews KA, Hasler BP, et al. Bedtime variability and metabolic health in midlife women: the SWAN Sleep Study. Sleep. 2016;39(2):457–465.
    1. Shan Z, Ma H, Xie M, et al. Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2015;38(3):529–537.
    1. Ford ES, Li C, Wheaton AG, Chapman DP, Perry GS, Croft JB. Sleep duration and body mass index and waist circumference among U.S. adults. Obesity (Silver Spring). 2014;22(2):598–607.
    1. Ruan H, Xun P, Cai W, He K, Tang Q. Habitual sleep duration and risk of childhood obesity: systematic review and dose-response meta-analysis of prospective cohort studies. Sci Rep. 2015;5:16160.
    1. Sperry SD, Scully ID, Gramzow RH, Jorgensen RS. Sleep duration and waist circumference in adults: a meta-analysis. Sleep. 2015;38(8):1269–1276.
    1. Bei B, Allen NB, Nicholas CL, Dudgeon P, Murray G, Trinder J. Actigraphy-assessed sleep during school and vacation periods: a naturalistic study of restricted and extended sleep opportunities in adolescents. J Sleep Res. 2014;23(1):107–117.
    1. Krueger PM, Reither EN, Peppard PE, Burger AE, Hale L. Cumulative exposure to short sleep and body mass outcomes: a prospective study. J Sleep Res. 2015;24(6):629–638.
    1. Goel N, Stunkard AJ, Rogers NL, et al. Circadian rhythm profiles in women with night eating syndrome. J Biol Rhythms. 2009;24(1):85–94.
    1. Arendt J. Biological rhythms during residence in polar regions. Chronobiol Int. 2012;29(4):379–394.
    1. Lockley SW, Skene DJ, Arendt J, Tabandeh H, Bird AC, Defrance R. Relationship between melatonin rhythms and visual loss in the blind. J Clin Endocrinol Metab. 1997;82(11):3763–3770.
    1. Van Someren EJ. Circadian and sleep disturbances in the elderly. Exp Gerontol. 2000;35(9–10):1229–1237.
    1. Harper DG, Volicer L, Stopa EG, McKee AC, Nitta M, Satlin A. Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry. 2005;13(5):359–368.
    1. Stephan FK, Zucker I. Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci USA. 1972;69(6):1583–1586.
    1. Moore RY, Eichler VB. Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res. 1972;42(1):201–206.
    1. Nagai K, Nishio T, Nakagawa H, Nakamura S, Fukuda Y. Effect of bilateral lesions of the suprachiasmatic nuclei on the circadian rhythm of food-intake. Brain Res. 1978;142(2):384–389.
    1. Ralph MR, Foster RG, Davis FC, Menaker M. Transplanted suprachiasmatic nucleus determines circadian period. Science. 1990;247(4945):975–978.
    1. Silver R, LeSauter J, Tresco PA, Lehman MN. A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms. Nature. 1996;382(6594):810–813.
    1. Kramer A, Yang FC, Snodgrass P, et al. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science. 2001;294(5551):2511–2515.
    1. Cheng MY, Bullock CM, Li C, et al. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002;417(6887):405–410.
    1. Kraves S, Weitz CJ. A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity. Nat Neurosci. 2006;9(2):212–219.
    1. Slawik H, Stoffel M, Riedl L, et al. Prospective study on salivary evening melatonin and sleep before and after pinealectomy in humans. J Biol Rhythms. 2016;31(1):82–93.
    1. Berson DM, Dunn FA, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science. 2002;295(5557):1070–1073.
    1. Moore RY. Neural control of the pineal gland. Behav Brain Res. 1996;73(1–2):125–130.
    1. Klein DC. Arylalkylamine N-acetyltransferase: “the Timezyme”. J Biol Chem. 2007;282(7):4233–4237.
    1. Johnston JD, Tournier BB, Andersson H, Masson-Pévet M, Lincoln GA, Hazlerigg DG. Multiple effects of melatonin on rhythmic clock gene expression in the mammalian pars tuberalis. Endocrinology. 2006;147(2):959–965.
    1. Sáenz de Miera C, Monecke S, Bartzen-Sprauer J, et al. A circannual clock drives expression of genes central for seasonal reproduction. Curr Biol. 2014;24(13):1500–1506.
    1. Buresová M, Dvoráková M, Zvolský P, Illnerová H. Human circadian rhythm in serum melatonin in short winter days and in simulated artificial long days. Neurosci Lett. 1992;136(2):173–176.
    1. Wehr TA, Giesen HA, Moul DE, Turner EH, Schwartz PJ. Suppression of men's responses to seasonal changes in day length by modern artificial lighting. Am J Physiol. 1995;269(1 Pt 2):R173–R178.
    1. Reppert SM, Weaver DR, Rivkees SA, Stopa EG. Putative melatonin receptors in a human biological clock. Science. 1988;242(4875):78–81.
    1. Weaver DR, Stehle JH, Stopa EG, Reppert SM. Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin. J Clin Endocrinol Metab. 1993;76(2):295–301.
    1. Dijk DJ, Czeisler CA. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci. 1995;15(5 Pt 1):3526–3538.
    1. Borbély AA. A two process model of sleep regulation. Hum Neurobiol. 1982;1(3):195–204.
    1. Borbély AA, Daan S, Wirz-Justice A, Deboer T. The two-process model of sleep regulation: a reappraisal. J Sleep Res. 2016;25(2):131–143.
    1. Kornhauser JM, Mayo KE, Takahashi JS. Light, immediate-early genes, and circadian rhythms. Behav Genet. 1996;26(3):221–240.
    1. Landgraf D, Wang LL, Diemer T, Welsh DK. NPAS2 compensates for loss of CLOCK in peripheral circadian oscillators. PLoS Genet. 2016;12(2):e1005882.
    1. Ribas-Latre A, Eckel-Mahan K. Interdependence of nutrient metabolism and the circadian clock system: importance for metabolic health. Mol Metab. 2016;5(3):133–152.
    1. Balsalobre A, Damiola F, Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell. 1998;93(6):929–937.
    1. Pagani L, Semenova EA, Moriggi E, et al. The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS One. 2010;5(10):e13376.
    1. Lane JM, Vlasac I, Anderson SG, et al. Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun. 2016;7:10889.
    1. Hu Y, Shmygelska A, Tran D, Eriksson N, Tung JY, Hinds DA. GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person. Nat Commun. 2016;7:10448.
    1. Hasan S, Santhi N, Lazar AS, et al. Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin. FASEB J. 2012;26(6):2414–2423.
    1. Pagani L, Schmitt K, Meier F, et al. Serum factors in older individuals change cellular clock properties. Proc Natl Acad Sci USA. 2011;108(17):7218–7223.
    1. Duffy JF, Dijk DJ, Klerman EB, Czeisler CA. Later endogenous circadian temperature nadir relative to an earlier wake time in older people. Am J Physiol. 1998;275(5 Pt 2):R1478–R1487.
    1. Duffy JF, Czeisler CA. Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans. Neurosci Lett. 2002;318(3):117–120.
    1. Korenčič A, Košir R, Bordyugov G, Lehmann R, Rozman D, Herzel H. Timing of circadian genes in mammalian tissues. Sci Rep. 2014;4:5782.
    1. Patel VR, Ceglia N, Zeller M, Eckel-Mahan K, Sassone-Corsi P, Baldi P. The pervasiveness and plasticity of circadian oscillations: the coupled circadian-oscillators framework. Bioinformatics. 2015;31(19):3181–3188.
    1. Storch KF, Lipan O, Leykin I, et al. Extensive and divergent circadian gene expression in liver and heart. Nature. 2002;417(6884):78–83.
    1. Harbour VL, Weigl Y, Robinson B, Amir S. Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day. PLoS One. 2013;8(10):e76391.
    1. Eckel-Mahan K, Sassone-Corsi P. Metabolism and the circadian clock converge. Physiol Rev. 2013;93(1):107–135.
    1. Zheng X, Sehgal A. AKT and TOR signaling set the pace of the circadian pacemaker. Curr Biol. 2010;20(13):1203–1208.
    1. Asher G, Gatfield D, Stratmann M, et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008;134(2):317–328.
    1. Masri S, Rigor P, Cervantes M, et al. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 2014;158(3):659–672.
    1. Wehr TA. Photoperiodism in humans and other primates: evidence and implications. J Biol Rhythms. 2001;16(4):348–364.
    1. Dopico XC, Evangelou M, Ferreira RC, et al. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nat Commun. 2015;6:7000.
    1. Pell JP, Sirel J, Marsden AK, Cobbe SM. Seasonal variations in out of hospital cardiopulmonary arrest. Heart. 1999;82(6):680–683.
    1. Pell JP, Cobbe SM. Seasonal variations in coronary heart disease. QJM. 1999;92(12):689–696.
    1. Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci USA. 2014;111(45):16219–16224.
    1. Reddy AB, Karp NA, Maywood ES, et al. Circadian orchestration of the hepatic proteome. Curr Biol. 2006;16(11):1107–1115.
    1. Eckel-Mahan KL, Patel VR, Mohney RP, Vignola KS, Baldi P, Sassone-Corsi P. Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci USA. 2012;109(14):5541–5546.
    1. Jang C, Lahens NF, Hogenesch JB, Sehgal A. Ribosome profiling reveals an important role for translational control in circadian gene expression. Genome Res. 2015;25(12):1836–1847.
    1. Robles MS, Cox J, Mann M. In-vivo quantitative proteomics reveals a key contribution of post-transcriptional mechanisms to the circadian regulation of liver metabolism. PLoS Genet. 2014;10(1):e1004047.
    1. Staiger D, Köster T. Spotlight on post-transcriptional control in the circadian system. Cell Mol Life Sci. 2011;68(1):71–83.
    1. Hirayama J, Sahar S, Grimaldi B, et al. CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature. 2007;450(7172):1086–1090.
    1. Kaasik K, Kivimäe S, Allen JJ, et al. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013;17(2):291–302.
    1. Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U. Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell. 2010;142(6):943–953.
    1. Vanselow K, Kramer A. Role of phosphorylation in the mammalian circadian clock. Cold Spring Harb Symp Quant Biol. 2007;72:167–176.
    1. Cardone L, Hirayama J, Giordano F, Tamaru T, Palvimo JJ, Sassone-Corsi P. Circadian clock control by SUMOylation of BMAL1. Science. 2005;309(5739):1390–1394.
    1. Mehra A, Baker CL, Loros JJ, Dunlap JC. Post-translational modifications in circadian rhythms. Trends Biochem Sci. 2009;34(10):483–490.
    1. O'Neill JS, Reddy AB. Circadian clocks in human red blood cells. Nature. 2011;469(7331):498–503.
    1. O'Neill JS, van Ooijen G, Dixon LE, et al. Circadian rhythms persist without transcription in a eukaryote. Nature. 2011;469(7331):554–558.
    1. Edgar RS, Green EW, Zhao Y, et al. Peroxiredoxins are conserved markers of circadian rhythms. Nature. 2012;485(7399):459–464.
    1. Nagoshi E, Saini C, Bauer C, Laroche T, Naef F, Schibler U. Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell. 2004;119(5):693–705.
    1. Izumo M, Pejchal M, Schook AC, et al. Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant. eLife. 2014;3:e04617.
    1. Kalsbeek A, Palm IF, La Fleur SE, et al. SCN outputs and the hypothalamic balance of life. J Biol Rhythms. 2006;21(6):458–469.
    1. Buijs RM, van Eden CG, Goncharuk VD, Kalsbeek A. The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system. J Endocrinol. 2003;177(1):17–26.
    1. la Fleur SE, Kalsbeek A, Wortel J, Buijs RM. Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver. Brain Res. 2000;871(1):50–56.
    1. Kalsbeek A, van Heerikhuize JJ, Wortel J, Buijs RM. A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V1 antagonist. J Neurosci. 1996;16(17):5555–5565.
    1. Kalsbeek A, Fliers E, Romijn JA, et al. The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology. 2001;142(6):2677–2685.
    1. Buijs RM, Chun SJ, Niijima A, Romijn HJ, Nagai K. Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake. J Comp Neurol. 2001;431(4):405–423.
    1. Kalsbeek A, Fliers E, Franke AN, Wortel J, Buijs RM. Functional connections between the suprachiasmatic nucleus and the thyroid gland as revealed by lesioning and viral tracing techniques in the rat. Endocrinology. 2000;141(10):3832–3841.
    1. Knigge KM, Scott DE. Structure and function of the median eminence. Am J Anat. 1970;129(2):223–243.
    1. So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc Natl Acad Sci USA. 2009;106(41):17582–17587.
    1. Reddy AB, Maywood ES, Karp NA, et al. Glucocorticoid signaling synchronizes the liver circadian transcriptome. Hepatology. 2007;45(6):1478–1488.
    1. Sujino M, Furukawa K, Koinuma S, et al. Differential entrainment of peripheral clocks in the rat by glucocorticoid and feeding. Endocrinology. 2012;153(5):2277–2286.
    1. Buhr ED, Yoo SH, Takahashi JS. Temperature as a universal resetting cue for mammalian circadian oscillators. Science. 2010;330(6002):379–385.
    1. Gerhart-Hines Z, Feng D, Emmett MJ, et al. The nuclear receptor Rev-erbα controls circadian thermogenic plasticity. Nature. 2013;503(7476):410–413.
    1. Carter SJ, Durrington HJ, Gibbs JE, et al. A matter of time: study of circadian clocks and their role in inflammation. J Leukoc Biol. 2016;99(4):549–560.
    1. Zhang X, Dube TJ, Esser KA. Working around the clock: circadian rhythms and skeletal muscle. J Appl Physiol (1985). 2009;107(5):1647–1654.
    1. Degaute JP, van de Borne P, Linkowski P, Van Cauter E. Quantitative analysis of the 24-hour blood pressure and heart rate patterns in young men. Hypertension. 1991;18(2):199–210.
    1. Bray MS, Shaw CA, Moore MW, et al. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol. 2008;294(2):H1036–H1047.
    1. Dyar KA, Ciciliot S, Wright LE, et al. Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock. Mol Metab. 2014;3(1):29–41.
    1. Kumar D, Wingate D, Ruckebusch Y. Circadian variation in the propagation velocity of the migrating motor complex. Gastroenterology. 1986;91(4):926–930.
    1. Goo RH, Moore JG, Greenberg E, Alazraki NP. Circadian variation in gastric emptying of meals in humans. Gastroenterology. 1987;93(3):515–518.
    1. Rao SS, Sadeghi P, Beaty J, Kavlock R, Ackerson K. Ambulatory 24-h colonic manometry in healthy humans. Am J Physiol Gastrointest Liver Physiol. 2001;280(4):G629–G639.
    1. Han S, Han SS, Zhang R, et al. Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nat Commun. 2015;6:7231.
    1. Hussain MM, Pan X. Circadian regulation of macronutrient absorption. J Biol Rhythms. 2015;30(6):459–469.
    1. Arasaradnam MP, Morgan L, Wright J, Gama R. Diurnal variation in lipoprotein lipase activity. Ann Clin Biochem. 2002;39(Pt 2):136–139.
    1. Adamovich Y, Rousso-Noori L, Zwighaft Z, et al. Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab. 2014;19(2):319–330.
    1. Douris N, Kojima S, Pan X, et al. Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes. Curr Biol. 2011;21(16):1347–1355.
    1. Thaiss CA, Zeevi D, Levy M, et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell. 2014;159(3):514–529.
    1. Liang X, Bushman FD, FitzGerald GA. Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Proc Natl Acad Sci USA. 2015;112(33):10479–10484.
    1. Leone V, Gibbons SM, Martinez K, et al. Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe. 2015;17(5):681–689.
    1. Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V. Glucagon-like peptide-1 (7–36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J Endocrinol. 1993;138(1):159–166.
    1. Iraki L, Bogdan A, Hakkou F, Amrani N, Abkari A, Touitou Y. Ramadan diet restrictions modify the circadian time structure in humans. A study on plasma gastrin, insulin, glucose, and calcium and on gastric pH. J Clin Endocrinol Metab. 1997;82(4):1261–1273.
    1. Morgan L, Arendt J, Owens D, et al. Effects of the endogenous clock and sleep time on melatonin, insulin, glucose and lipid metabolism. J Endocrinol. 1998;157(3):443–451.
    1. Van Cauter E, Blackman JD, Roland D, Spire JP, Refetoff S, Polonsky KS. Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J Clin Invest. 1991;88(3):934–942.
    1. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA. 2009;106(11):4453–4458.
    1. Scheer FA, Chan JL, Fargnoli J, et al. Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010;53(11):2401–2405.
    1. Takahashi Y, Kipnis DM, Daughaday WH. Growth hormone secretion during sleep. J Clin Invest. 1968;47(9):2079–2090.
    1. Ho KY, Veldhuis JD, Johnson ML, et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest. 1988;81(4):968–975.
    1. Jaffe CA, Ocampo-Lim B, Guo W, et al. Regulatory mechanisms of growth hormone secretion are sexually dimorphic. J Clin Invest. 1998;102(1):153–164.
    1. Møller N, Jørgensen JO, Schmitz O, et al. Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol. 1990;258(1 Pt 1):E86–E91.
    1. Møller N, Jørgensen JO. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009;30(2):152–177.
    1. Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 1998;19(3):225–268.
    1. Ben-Jonathan N, Hugo ER, Brandebourg TD, LaPensee CR. Focus on prolactin as a metabolic hormone. Trends Endocrinol Metab. 2006;17(3):110–116.
    1. Waldstreicher J, Duffy JF, Brown EN, Rogacz S, Allan JS, Czeisler CA. Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels- a clinical research center study. J Clin Endocrinol Metab. 1996;81(4):1483–1487.
    1. Roky R, Valatx JL, Jouvet M. Effect of prolactin on the sleep-wake cycle in the rat. Neurosci Lett. 1993;156(1–2):117–120.
    1. Linkowski P, Spiegel K, Kerkhofs M, et al. Genetic and environmental influences on prolactin secretion during wake and during sleep. Am J Physiol. 1998;274(5 Pt 1):E909–E919.
    1. Kräuchi K, Cajochen C, Wirz-Justice A. A relationship between heat loss and sleepiness: effects of postural change and melatonin administration. J Appl Physiol (1985). 1997;83(1):134–139.
    1. Tuomi T, Nagorny CL, Singh P, et al. Increased melatonin signaling is a risk factor for type 2 diabetes. Cell Metab. 2016;23(6):1067–1077.
    1. Prokopenko I, Langenberg C, Florez JC, et al. Variants in MTNR1B influence fasting glucose levels. Nat Genet. 2009;41(1):77–81.
    1. Lyssenko V, Nagorny CL, Erdos MR, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009;41(1):82–88.
    1. Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2009;41(1):89–94.
    1. Lane JM, Chang AM, Bjonnes AC, et al. Impact of common diabetes risk variant in MTNR1B on sleep, circadian, and melatonin physiology. Diabetes. 2016;65(6):1741–1751.
    1. Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol. 2003;50(4):1129–1146.
    1. Scheer FA, Morris CJ, Shea SA. The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors. Obesity (Silver Spring). 2013;21(3):421–423.
    1. Mastronardi CA, Walczewska A, Yu WH, Karanth S, Parlow AF, McCann SM. The possible role of prolactin in the circadian rhythm of leptin secretion in male rats. Proc Soc Exp Biol Med. 2000;224(3):152–158.
    1. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999;354(9188):1435–1439.
    1. Thomas M, Sing H, Belenky G, et al. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res. 2000;9(4):335–352.
    1. Cedernaes J, Lampola L, Axelsson EK, et al. A single night of partial sleep loss impairs fasting insulin sensitivity but does not affect cephalic phase insulin release in young men. J Sleep Res. 2016;25(1):5–10.
    1. Rao MN, Neylan TC, Grunfeld C, Mulligan K, Schambelan M, Schwarz JM. Subchronic sleep restriction causes tissue-specific insulin resistance. J Clin Endocrinol Metab. 2015;100(4):1664–1671.
    1. Broussard JL, Ehrmann DA, Van Cauter E, Tasali E, Brady MJ. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. 2012;157(8):549–557.
    1. Cedernaes J, Osler ME, Voisin S, et al. Acute sleep loss induces tissue-specific epigenetic and transcriptional alterations to circadian clock genes in men. J Clin Endocrinol Metab. 2015;100(9):E1255–E1261.
    1. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;1(7285):785–789.
    1. Broussard JL, Chapotot F, Abraham V, et al. Sleep restriction increases free fatty acids in healthy men. Diabetologia. 2015;58(4):791–798.
    1. Irwin M, Thompson J, Miller C, Gillin JC, Ziegler M. Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. J Clin Endocrinol Metab. 1999;84(6):1979–1985.
    1. Mullington JM, Simpson NS, Meier-Ewert HK, Haack M. Sleep loss and inflammation. Best Pract Res Clin Endocrinol Metab. 2010;24(5):775–784.
    1. Lasselin J, Rehman JU, Åkerstedt T, Lekander M, Axelsson J. Effect of long-term sleep restriction and subsequent recovery sleep on the diurnal rhythms of white blood cell subpopulations. Brain Behav Immun. 2015;47:93–99.
    1. Tsujimura T, Matsuo Y, Keyaki T, Sakurada K, Imanishi J. Correlations of sleep disturbance with the immune system in type 2 diabetes mellitus. Diabetes Res Clin Pract. 2009;85(3):286–292.
    1. Schmid SM, Hallschmid M, Jauch-Chara K, Lehnert H, Schultes B. Sleep timing may modulate the effect of sleep loss on testosterone. Clin Endocrinol (Oxf). 2012;77(5):749–754.
    1. Tasali E, Leproult R, Ehrmann DA, Van Cauter E. Slow-wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci USA. 2008;105(3):1044–1049.
    1. Shaw ND, McHill AW, Schiavon M, et al. Effect of slow wave sleep disruption on metabolic parameters in adolescents. Sleep. 2016;39(8):1591–1599.
    1. Eckel RH, Depner CM, Perreault L, et al. Morning circadian misalignment during short sleep duration impacts insulin sensitivity. Curr Biol. 2015;25(22):3004–3010.
    1. Robertson MD, Russell-Jones D, Umpleby AM, Dijk DJ. Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men. Metabolism. 2013;62(2):204–211.
    1. Reutrakul S, Van Cauter E. Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes. Ann NY Acad Sci. 2014;1311:151–173.
    1. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006–1014.
    1. Pamidi S, Wroblewski K, Broussard J, et al. Obstructive sleep apnea in young lean men: impact on insulin sensitivity and secretion. Diabetes Care. 2012;35(11):2384–2389.
    1. Aronsohn RS, Whitmore H, Van Cauter E, Tasali E. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes. Am J Respir Crit Care Med. 2010;181(5):507–513.
    1. Wang X, Bi Y, Zhang Q, Pan F. Obstructive sleep apnoea and the risk of type 2 diabetes: a meta-analysis of prospective cohort studies. Respirology. 2013;18(1):140–146.
    1. Maasilta P, Bachour A, Teramo K, Polo O, Laitinen LA. Sleep-related disordered breathing during pregnancy in obese women. Chest. 2001;120(5):1448–1454.
    1. Reutrakul S, Zaidi N, Wroblewski K, et al. Interactions between pregnancy, obstructive sleep apnea, and gestational diabetes mellitus. J Clin Endocrinol Metab. 2013;98(10):4195–4202.
    1. Martnez-Ceron E, Fernndez-Navarro I, Garcia-Rio F. Effects of continuous positive airway pressure treatment on glucose metabolism in patients with obstructive sleep apnea. Sleep Med Rev. 2016;25:121–130.
    1. Schmid SM, Hallschmid M, Jauch-Chara K, et al. Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men. Am J Clin Nutr. 2009;90(6):1476–1482.
    1. Capers PL, Fobian AD, Kaiser KA, Borah R, Allison DB. A systematic review and meta-analysis of randomized controlled trials of the impact of sleep duration on adiposity and components of energy balance. Obes Rev. 2015;16(9):771–782.
    1. Simon SL, Field J, Miller LE, DiFrancesco M, Beebe DW. Sweet/dessert foods are more appealing to adolescents after sleep restriction. PLoS One. 2015;10(2):e0115434.
    1. Chapman CD, Nilsson EK, Nilsson VC, et al. Acute sleep deprivation increases food purchasing in men. Obesity (Silver Spring). 2013;21(12):E555–E560.
    1. Pejovic S, Vgontzas AN, Basta M, et al. Leptin and hunger levels in young healthy adults after one night of sleep loss. J Sleep Res. 2010;19(4):552–558.
    1. Simpson NS, Banks S, Dinges DF. Sleep restriction is associated with increased morning plasma leptin concentrations, especially in women. Biol Res Nurs. 2010;12(1):47–53.
    1. Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004;141(11):846–850.
    1. Broussard JL, Kilkus JM, Delebecque F, et al. Elevated ghrelin predicts food intake during experimental sleep restriction. Obesity (Silver Spring). 2016;24(1):132–138.
    1. Hanlon EC, Tasali E, Leproult R, et al. Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol. Sleep. 2016;39(3):653–664.
    1. Spaeth AM, Dinges DF, Goel N. Resting metabolic rate varies by race and by sleep duration. Obesity (Silver Spring). 2015;23(12):2349–2356.
    1. Nedeltcheva AV, Kilkus JM, Imperial J, Schoeller DA, Penev PD. Insufficient sleep undermines dietary efforts to reduce adiposity. Ann Intern Med. 2010;153(7):435–441.
    1. Verhoef SP, Camps SG, Gonnissen HK, Westerterp KR, Westerterp-Plantenga MS. Concomitant changes in sleep duration and body weight and body composition during weight loss and 3-mo weight maintenance. Am J Clin Nutr. 2013;98(1):25–31.
    1. Spaeth AM, Dinges DF, Goel N. Phenotypic vulnerability of energy balance responses to sleep loss in healthy adults. Sci Rep. 2015;5:14920.
    1. Landolt HP. Genotype-dependent differences in sleep, vigilance, and response to stimulants. Curr Pharm Des. 2008;14(32):3396–3407.
    1. Pellegrino R, Kavakli IH, Goel N, et al. A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. Sleep. 2014;37(8):1327–1336.
    1. Davies SK, Ang JE, Revell VL, et al. Effect of sleep deprivation on the human metabolome. Proc Natl Acad Sci USA. 2014;111(29):10761–10766.
    1. Dallmann R, Viola AU, Tarokh L, Cajochen C, Brown SA. The human circadian metabolome. Proc Natl Acad Sci USA. 2012;109(7):2625–2629.
    1. Chua EC, Shui G, Lee IT, et al. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proc Natl Acad Sci USA. 2013;110(35):14468–14473.
    1. Weljie AM, Meerlo P, Goel N, et al. Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. Proc Natl Acad Sci USA. 2015;112(8):2569–2574.
    1. Aho V, Ollila HM, Kronholm E, et al. Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Sci Rep. 2016;6:24828.
    1. Möller-Levet CS, Archer SN, Bucca G, et al. Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci USA. 2013;110(12):E1132–E1141.
    1. Archer SN, Laing EE, Möller-Levet CS, et al. Mistimed sleep disrupts circadian regulation of the human transcriptome. Proc Natl Acad Sci USA. 2014;111(6):E682–E691.
    1. Patel VR, Eckel-Mahan K, Sassone-Corsi P, Baldi P. CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics. Nat Methods. 2012;9(8):772–773.
    1. Spaeth AM, Dinges DF, Goel N. Effects of experimental sleep restriction on weight gain, caloric intake, and meal timing in healthy adults. Sleep. 2013;36(7):981–990.
    1. Markwald RR, Melanson EL, Smith MR, et al. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc Natl Acad Sci USA. 2013;110(14):5695–5700.
    1. LeRoux A, Wright L, Perrot T, Rusak B. Impact of menstrual cycle phase on endocrine effects of partial sleep restriction in healthy women. Psychoneuroendocrinology. 2014;49:34–46.
    1. Horne JA. Human REM sleep: influence on feeding behaviour, with clinical implications. Sleep Med. 2015;16(8):910–916.
    1. Wansink B, Sobal J. Mindless eating: the 200 daily food decisions we overlook. Environ Behav. 2007;39:106–123.
    1. St-Onge MP, McReynolds A, Trivedi ZB, Roberts AL, Sy M, Hirsch J. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. Am J Clin Nutr. 2012;95(4):818–824.
    1. Benedict C, Brooks SJ, O'Daly OG, et al. Acute sleep deprivation enhances the brain's response to hedonic food stimuli: an fMRI study. J Clin Endocrinol Metab. 2012;97(3):E443–E447.
    1. Mehta S, Melhorn SJ, Smeraglio A, et al. Regional brain response to visual food cues is a marker of satiety that predicts food choice. Am J Clin Nutr. 2012;96(5):989–999.
    1. St-Onge MP, Wolfe S, Sy M, Shechter A, Hirsch J. Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals. Int J Obes (Lond). 2014;38(3):411–416.
    1. Rozin P, Dow S, Moscovitch M, Rajaram S. What causes humans to begin and end a meal? A role for memory for what has been eaten, as evidenced by a study of multiple meal eating in amnesic patients. Psychol Sci. 1998;9:392–396.
    1. Prince TM, Abel T. The impact of sleep loss on hippocampal function. Learn Mem. 2013;20(10):558–569.
    1. Parent MB, Darling JN, Henderson YO. Remembering to eat: hippocampal regulation of meal onset. Am J Physiol Regul Integr Comp Physiol. 2014;306(10):R701–R713.
    1. Klepeis NE, Nelson WC, Ott WR, et al. The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. J Expo Anal Environ Epidemiol. 2001;11(3):231–252.
    1. Hébert M, Dumont M, Paquet J. Seasonal and diurnal patterns of human illumination under natural conditions. Chronobiol Int. 1998;15(1):59–70.
    1. Diffey BL. An overview analysis of the time people spend outdoors. Br J Dermatol. 2011;164(4):848–854.
    1. Cole RJ, Kripke DF, Wisbey J, et al. Seasonal variation in human illumination exposure at two different latitudes. J Biol Rhythms. 1995;10(4):324–334.
    1. Wright KP, Jr, McHill AW, Birks BR, Griffin BR, Rusterholz T, Chinoy ED. Entrainment of the human circadian clock to the natural light-dark cycle. Curr Biol. 2013;23(16):1554–1558.
    1. Cajochen C. Alerting effects of light. Sleep Med Rev. 2007;11(6):453–464.
    1. Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014;348:g2035.
    1. Gutierrez-Monreal MA, Cuevas-Diaz Duran R, Moreno-Cuevas JE, Scott SP. A role for 1α,25-dihydroxyvitamin d3 in the expression of circadian genes. J Biol Rhythms. 2014;29(5):384–388.
    1. Bertisch SM, Sillau S, de Boer IH, Szklo M, Redline S. 25-Hydroxyvitamin D concentration and sleep duration and continuity: multi-ethnic study of atherosclerosis. Sleep. 2015;38(8):1305–1311.
    1. Kim JH, Chang JH, Kim DY, Kang JW. Association between self-reported sleep duration and serum vitamin D level in elderly Korean adults. J Am Geriatr Soc. 2014;62(12):2327–2332.
    1. Massa J, Stone KL, Wei EK, et al. Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study. Sleep. 2015;38(2):251–257.
    1. Cinzano P, Falchi F, Elvidge CD. The first World Atlas of the artificial night sky brightness. Mon Not R Astron Soc. 2001;328(3):689–707.
    1. de la Iglesia HO, Fernndez-Duque E, Golombek DA, et al. Access to electric light is associated with shorter sleep duration in a traditionally hunter-gatherer community. J Biol Rhythms. 2015;30(4):342–350.
    1. Moreno CR, Vasconcelos S, Marqueze EC, et al. Sleep patterns in Amazon rubber tappers with and without electric light at home. Sci Rep. 2015;5:14074.
    1. Yetish G, Kaplan H, Gurven M, et al. Natural sleep and its seasonal variations in three pre-industrial societies. Curr Biol. 2015;25(21):2862–2868.
    1. de la Iglesia HO, Moreno C, Lowden A, et al. Ancestral sleep. Curr Biol. 2016;26(7):R271–R272.
    1. Glickman G, Levin R, Brainard GC. Ocular input for human melatonin regulation: relevance to breast cancer. Neuro Endocrinol Lett. 2002;23(suppl 2):17–22.
    1. Thapan K, Arendt J, Skene DJ. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol. 2001;535(Pt 1):261–267.
    1. Chang AM, Aeschbach D, Duffy JF, Czeisler CA. Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proc Natl Acad Sci USA. 2015;112(4):1232–1237.
    1. Rybnikova NA, Haim A, Portnov BA. Does artificial light-at-night exposure contribute to the worldwide obesity pandemic? Int J Obes (Lond). 2016;40(5):815–823.
    1. Reid KJ, Santostasi G, Baron KG, Wilson J, Kang J, Zee PC. Timing and intensity of light correlate with body weight in adults. PLoS One. 2014;9(4):e92251.
    1. Romon M, Nuttens MC, Fievet C, et al. Increased triglyceride levels in shift workers. Am J Med. 1992;93(3):259–262.
    1. Lund J, Arendt J, Hampton SM, English J, Morgan LM. Postprandial hormone and metabolic responses amongst shift workers in Antarctica. J Endocrinol. 2001;171(3):557–564.
    1. Dawson D, Reid K. Fatigue, alcohol and performance impairment. Nature. 1997;388(6639):235.
    1. Barnes RG, Deacon SJ, Forbes MJ, Arendt J. Adaptation of the 6-sulphatoxymelatonin rhythm in shiftworkers on offshore oil installations during a 2-week 12-h night shift. Neurosci Lett. 1998;241(1):9–12.
    1. Midwinter MJ, Arendt J. Adaptation of the melatonin rhythm in human subjects following night-shift work in Antarctica. Neurosci Lett. 1991;122(2):195–198.
    1. Ross JK, Arendt J, Horne J, Haston W. Night-shift work in Antarctica: sleep characteristics and bright light treatment. Physiol Behav. 1995;57(6):1169–1174.
    1. Gibbs M, Hampton S, Morgan L, Arendt J. Predicting circadian response to abrupt phase shift: 6-sulphatoxymelatonin rhythms in rotating shift workers offshore. J Biol Rhythms. 2007;22(4):368–370.
    1. Weibel L, Brandenberger G. Disturbances in hormonal profiles of night workers during their usual sleep and work times. J Biol Rhythms. 1998;13(3):202–208.
    1. Leproult R, Holmbäck U, Van Cauter E. Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss. Diabetes. 2014;63(6):1860–1869.
    1. McHill AW, Melanson EL, Higgins J, et al. Impact of circadian misalignment on energy metabolism during simulated nightshift work. Proc Natl Acad Sci USA. 2014;111(48):17302–17307.
    1. Gonnissen HK, Rutters F, Mazuy C, Martens EA, Adam TC, Westerterp-Plantenga MS. Effect of a phase advance and phase delay of the 24-h cycle on energy metabolism, appetite, and related hormones. Am J Clin Nutr. 2012;96(4):689–697.
    1. Morris CJ, Purvis TE, Hu K, Scheer FA. Circadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci USA. 2016;113(10):E1402–E1411.
    1. Morris CJ, Yang JN, Garcia JI, et al. Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proc Natl Acad Sci USA. 2015;112(17):E2225–E2234.
    1. Wright KP, Jr, Drake AL, Frey DJ, et al. Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance. Brain Behav Immun. 2015;47:24–34.
    1. Buxton OM, Cain SW, O'Connor SP, et al. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med. 2012;4(129):129ra43.
    1. Morris CJ, Purvis TE, Mistretta J, Scheer FA. Effects of the internal circadian system and circadian misalignment on glucose tolerance in chronic shift workers. J Clin Endocrinol Metab. 2016;101(3):1066–1074.
    1. Bambra CL, Whitehead MM, Sowden AJ, Akers J, Petticrew MP. Shifting schedules: the health effects of reorganizing shift work. Am J Prev Med. 2008;34(5):427–434.
    1. Thorne H, Hampton S, Morgan L, Skene DJ, Arendt J. Differences in sleep, light, and circadian phase in offshore 18:00–06:00 h and 19:00–07:00 h shift workers. Chronobiol Int. 2008;25(2):225–235.
    1. Saksvik IB, Bjorvatn B, Hetland H, Sandal GM, Pallesen S. Individual differences in tolerance to shift work–a systematic review. Sleep Med Rev. 2011;15(4):221–235.
    1. Kantermann T, Wehrens SM, Ulha MA, Moreno C, Skene DJ. Noisy and individual, but doable: shift-work research in humans. Prog Brain Res. 2012;199:399–411.
    1. Vetter C, Devore EE, Ramin CA, Speizer FE, Willett WC, Schernhammer ES. Mismatch of sleep and work timing and risk of type 2 diabetes. Diabetes Care. 2015;38(9):1707–1713.
    1. Vetter C, Fischer D, Matera JL, Roenneberg T. Aligning work and circadian time in shift workers improves sleep and reduces circadian disruption. Curr Biol. 2015;25(7):907–911.
    1. Turek FW, Joshu C, Kohsaka A, et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science. 2005;308(5724):1043–1045.
    1. Paschos GK, Ibrahim S, Song WL, et al. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med. 2012;18(12):1768–1777.
    1. Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP. Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev. 2006;20(14):1868–1873.
    1. Williams SR, Zies D, Mullegama SV, Grotewiel MS, Elsea SH. Smith-Magenis syndrome results in disruption of CLOCK gene transcription and reveals an integral role for RAI1 in the maintenance of circadian rhythmicity. Am J Hum Genet. 2012;90(6):941–949.
    1. Below JE, Gamazon ER, Morrison JV, et al. Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. Diabetologia. 2011;54(8):2047–2055.
    1. Dupuis J, Langenberg C, Prokopenko I, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42(2):105–116.
    1. Woon PY, Kaisaki PJ, Bragança J, et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci USA. 2007;104(36):14412–14417.
    1. Kovanen L, Saarikoski ST, Haukka J, et al. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Alcohol Alcohol. 2010;45(4):303–311.
    1. Sookoian S, Castaño G, Gemma C, Gianotti TF, Pirola CJ. Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease. World J Gastroenterol. 2007;13(31):4242–4248.
    1. Scott EM, Carter AM, Grant PJ. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond). 2008;32(4):658–662.
    1. Tsuzaki K, Kotani K, Sano Y, Fujiwara S, Takahashi K, Sakane N. The association of the Clock 3111 T/C SNP with lipids and lipoproteins including small dense low-density lipoprotein: results from the Mima study. BMC Med Genet. 2010;11:150.
    1. Sookoian S, Gemma C, Gianotti TF, Burgueño A, Castaño G, Pirola CJ. Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr. 2008;87(6):1606–1615.
    1. Uemura H, Katsuura-Kamano S, Yamaguchi M, et al. Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population. J Diabetes. 2016;8(5):667–676.
    1. Valladares M, Obregón AM, Chaput JP. Association between genetic variants of the clock gene and obesity and sleep duration. J Physiol Biochem. 2015;71(4):855–860.
    1. Dashti HS, Follis JL, Smith CE, et al. Gene-environment interactions of circadian-related genes for cardiometabolic traits. Diabetes Care. 2015;38(8):1456–1466.
    1. Danilenko KV, Cajochen C, Wirz-Justice A. Is sleep per se a zeitgeber in humans? J Biol Rhythms. 2003;18(2):170–178.
    1. Leproult R, Deliens G, Gilson M, Peigneux P. Beneficial impact of sleep extension on fasting insulin sensitivity in adults with habitual sleep restriction. Sleep. 2015;38(5):707–715.
    1. Killick R, Hoyos CM, Melehan KL, Dungan GC, 2nd, Poh J, Liu PY. Metabolic and hormonal effects of ‘catch-up’ sleep in men with chronic, repetitive, lifestyle-driven sleep restriction. Clin Endocrinol (Oxf). 2015;83(4):498–507.
    1. Mantua J, Spencer RM. The interactive effects of nocturnal sleep and daytime naps in relation to serum C-reactive protein. Sleep Med. 2015;16(10):1213–1216.
    1. Faraut B, Nakib S, Drogou C, et al. Napping reverses the salivary interleukin-6 and urinary norepinephrine changes induced by sleep restriction. J Clin Endocrinol Metab. 2015;100(3):E416–E426.
    1. Chaput JP, Desprs JP, Bouchard C, Tremblay A. Longer sleep duration associates with lower adiposity gain in adult short sleepers. Int J Obes (Lond). 2012;36(5):752–756.
    1. Tasali E, Chapotot F, Wroblewski K, Schoeller D. The effects of extended bedtimes on sleep duration and food desire in overweight young adults: a home-based intervention. Appetite. 2014;80:220–224.
    1. Beebe DW, Zhou A, Rausch J, Noe O, Simon SL. The impact of early bedtimes on adolescent caloric intake varies by chronotype. J Adolesc Health. 2015;57(1):120–122.
    1. Minges KE, Redeker NS. Delayed school start times and adolescent sleep: a systematic review of the experimental evidence. Sleep Med Rev. 2016;28:86–95.
    1. Meng QJ, Maywood ES, Bechtold DA, et al. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc Natl Acad Sci USA. 2010;107(34):15240–15245.
    1. Pilorz V, Cunningham PS, Jackson A, et al. A novel mechanism controlling resetting speed of the circadian clock to environmental stimuli. Curr Biol. 2014;24(7):766–773.
    1. An S, Harang R, Meeker K, et al. A neuropeptide speeds circadian entrainment by reducing intercellular synchrony. Proc Natl Acad Sci USA. 2013;110(46):E4355–E4361.
    1. He B, Chen Z. Molecular targets for small-molecule modulators of circadian clocks. Curr Drug Metab. 2016;17(5):503–512.
    1. Chen AH, Lubkowicz D, Yeong V, Chang RL, Silver PA. Transplantability of a circadian clock to a noncircadian organism. Sci Adv. 2015;1(5):pii:e1500358.
    1. Solt LA, Wang Y, Banerjee S, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012;485(7396):62–68.
    1. Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep Med Rev. 2005;9(1):25–39.
    1. Amstrup AK, Sikjaer T, Pedersen SB, Heickendorff L, Mosekilde L, Rejnmark L. Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: a randomized placebo-controlled trial. Clin Endocrinol (Oxf). 2016;84(3):342–347.
    1. Garfinkel D, Zorin M, Wainstein J, Matas Z, Laudon M, Zisapel N. Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study. Diabetes Metab Syndr Obes. 2011;4:307–313.
    1. Burke TM, Markwald RR, McHill AW, et al. Effects of caffeine on the human circadian clock in vivo and in vitro. Sci Transl Med. 2015;7(305):305ra146.
    1. Pirard C, Beaumont M, Enslen M, et al. Resynchronization of hormonal rhythms after an eastbound flight in humans: effects of slow-release caffeine and melatonin. Eur J Appl Physiol. 2001;85(1–2):144–150.
    1. van der Lely S, Frey S, Garbazza C, et al. Blue blocker glasses as a countermeasure for alerting effects of evening light-emitting diode screen exposure in male teenagers. J Adolesc Health. 2015;56(1):113–119.
    1. Gringras P, Middleton B, Skene DJ, Revell VL. Bigger, brighter, bluer-better? Current light-emitting devices - adverse sleep properties and preventative strategies. Front Public Health. 2015;3:233.
    1. Revell VL, Barrett DC, Schlangen LJ, Skene DJ. Predicting human nocturnal nonvisual responses to monochromatic and polychromatic light with a melanopsin photosensitivity function. Chronobiol Int. 2010;27(9–10):1762–1777.
    1. Chang AM, Santhi N, St Hilaire M, et al. Human responses to bright light of different durations. J Physiol. 2012;590(13):3103–3112.
    1. Czeisler CA, Kronauer RE, Allan JS, et al. Bright light induction of strong (type 0) resetting of the human circadian pacemaker. Science. 1989;244(4910):1328–1333.
    1. Potter GD, Cade JE, Grant PJ, Hardie LJ. Nutrition and the circadian system. Br J Nutr. 2016;116(3):434–442.
    1. Stephan FK, Swann JM, Sisk CL. Entrainment of circadian rhythms by feeding schedules in rats with suprachiasmatic lesions. Behav Neural Biol. 1979;25(4):545–554.
    1. Damiola F, Le Minh N, Preitner N, Kornmann B, Fleury-Olela F, Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 2000;14(23):2950–2961.
    1. Mendoza J, Graff C, Dardente H, Pevet P, Challet E. Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle. J Neurosci. 2005;25(6):1514–1522.
    1. Zarrinpar A, Chaix A, Panda S. Daily eating patterns and their impact on health and disease. Trends Endocrinol Metab. 2016;27(2):69–83.
    1. Gill S, Panda S. A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits. Cell Metab. 2015;22(5):789–798.
    1. Jakubowicz D, Barnea M, Wainstein J, Froy O. High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women. Obesity (Silver Spring). 2013;21(12):2504–2512.
    1. Garaulet M, Gmez-Abelln P, Alburquerque-Bjar JJ, Lee YC, Ordovs JM, Scheer FA. Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond). 2013;37(4):604–611.
    1. Hsieh WH, Escobar C, Yugay T, et al. Simulated shift work in rats perturbs multiscale regulation of locomotor activity. J R Soc Interface. 2014;11(96):pii:20140318.
    1. Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: involvement of the circadian pacemaker. Proc Natl Acad Sci USA. 2009;106(8):2490–2494.
    1. Barger LK, Wright KP, Jr, Hughes RJ, Czeisler CA. Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light. Am J Physiol Regul Integr Comp Physiol. 2004;286(6):R1077–R1084.
    1. Wolff G, Esser KA. Scheduled exercise phase shifts the circadian clock in skeletal muscle. Med Sci Sports Exerc. 2012;44(9):1663–1670.
    1. Scheer FA, Hu K, Evoniuk H, et al. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci USA. 2010;107(47):20541–20546.
    1. Fonken LK, Meléndez-Fernández OH, Weil ZM, Nelson RJ. Exercise attenuates the metabolic effects of dim light at night. Physiol Behav. 2014;124:33–36.
    1. Mônico-Neto M, Antunes HK, Lee KS, et al. Resistance training minimizes catabolic effects induced by sleep deprivation in rats. Appl Physiol Nutr Metab. 2015;40(11):1143–1150.
    1. Bailey M, Silver R. Sex differences in circadian timing systems: implications for disease. Front Neuroendocrinol. 2014;35(1):111–139.
    1. Bei B, Wiley JF, Trinder J, Manber R. Beyond the mean: A systematic review on the correlates of daily intraindividual variability of sleep/wake patterns. Sleep Med Rev. 2016;28:108–124.
    1. Seok J, Warren HS, Cuenca AG, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA. 2013;110(9):3507–3512.

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