Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

Haozhe Yu, Yifei Yuan, Wenyu Wu, Weizhen Zeng, Louis Tong, Yu Zhang, Yun Feng, Haozhe Yu, Yifei Yuan, Wenyu Wu, Weizhen Zeng, Louis Tong, Yu Zhang, Yun Feng

Abstract

Purpose: Previous studies suggest that overnight orthokeratology (OOK) may be detrimental to tear function. We aimed to investigate the effect of OOK on lipid layer thickness (LLT), blink pattern, and meibomian gland and elucidate the relationship of these variables.

Methods: Thirty-seven participants who wore OOK lenses every night for at least 2 years and twenty-four healthy non-contact lens wearers (controls) were enrolled in this retrospective study. LipiView interferometry, blink pattern analysis, the ocular surface status, and morphology and function of the meibomian gland were determined.

Results: The OOK group and healthy controls had similar LLT, blink patterns, ocular surface status, and the function of the meibomian gland. OOK participants demonstrated higher meiboscore in the lower eyelids (p < 0.05) but not in the upper eyelids. Within the OOK group, LLT was significantly impacted by the partial blink rate (p < 0.05) and the total score of the upper meibomian gland (p = 0.10).

Conclusions: Wearing OOK for 2 or more years increased lower eyelid meibomian gland dropout but did not have a reduction of LLT.

Keywords: LipiView; dry eye; lipid layer thickness; meibomian gland; orthokeratology.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2022 Yu, Yuan, Wu, Zeng, Tong, Zhang and Feng.

Figures

Figure 1
Figure 1
Comparison of (A) ocular surface disease index (OSDI) score, (B) cornea staining score, (C) tear break-up time (TBUT), (D) tear secretion, (E) LLT, (F) partial blinks, (G) partial blinks and their rate (PBR), and (H) total blinks between orthokeratology (OOK) group and control group.
Figure 2
Figure 2
Meiboscore, meibum properties, and meibomian gland expressibility of the upper and lower eyelid in the OOK group and control group.

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