Cognitive and structural cerebral changes in amnestic mild cognitive impairment due to Alzheimer's disease after multicomponent training

Camila Vieira Ligo Teixeira, Thiago Junqueira Ribeiro de Rezende, Marina Weiler, Thamires Naela Cardoso Magalhães, Ana Flávia Mac Knight Carletti-Cassani, Thiago Quinaglia Araújo Costa Silva, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Mariana Pires Franco, Pedro Eduardo Nechio, Paula Teixeira Fernandes, Fernando Cendes, Marcio Luis Balthazar, Camila Vieira Ligo Teixeira, Thiago Junqueira Ribeiro de Rezende, Marina Weiler, Thamires Naela Cardoso Magalhães, Ana Flávia Mac Knight Carletti-Cassani, Thiago Quinaglia Araújo Costa Silva, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Mariana Pires Franco, Pedro Eduardo Nechio, Paula Teixeira Fernandes, Fernando Cendes, Marcio Luis Balthazar

Abstract

Introduction: Information about how physical exercise affects patients with amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD) is still missing. This study evaluated the impact of multicomponent exercise training on cognition and brain structure in aMCI subjects with cerebral spinal fluid positive AD biomarkers.

Methods: Forty aMCI subjects were divided in training (multicomponent exercise thrice a week for 6 months) and nontraining groups. Assessments included cardiorespiratory fitness, neurocognitive tests, and a structural magnetic resonance imaging using 3.0 T scanner. FreeSurfer software analyzed hippocampal volume and cortical thickness.

Results: The training group showed increased volume in both hippocampi and better performance in episodic memory test after 6 months. In contrast, the nontraining group declined in functional activities, recognition, and cardiorespiratory fitness for the same period.

Discussion: Multicomponent exercise seems to improve hippocampal volume and episodic memory, and maintains VO2max in aMCI due to AD.

Keywords: Cognition; Cortical thickness; Hippocampus; Multicomponent exercise; aMCI due to AD.

Figures

Fig. 1
Fig. 1
The flow chart of recruitment and exclusion of participants. Abbreviations: aMCI, amnestic mild cognitive impairment; MRI, magnetic resonance imaging.
Fig. 2
Fig. 2
Differences in VO2max after 6 months in training and nontraining groups. ∗Significant interaction between-groups; †significant interaction within-groups.

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