Pertussis in high-risk groups: an overview of the past quarter-century

Victoria A Jenkins, Miloje Savic, Walid Kandeil, Victoria A Jenkins, Miloje Savic, Walid Kandeil

Abstract

Infectious diseases can impact chronic medical conditions. However, it is currently not clear how pertussis correlates with preexisting or underlying disorders. We reviewed literature from the last 25 years to describe the burden and impact of pertussis infection in specific risk groups in individuals aged ≥11 years. Our literature search returned 543 hits, of which 18 were eligible for this review. Adolescents and adults with underlying conditions, such as asthma, chronic obstructive pulmonary disease (COPD), or obesity are potentially at increased risk of pertussis infection. Immunodeficiency and smoking have also been associated with worsened pertussis symptoms and an increased pertussis-related hospitalization rate. In patients with pertussis and preexisting asthma or COPD, symptoms were worsened, and health-care costs were consequently increased. Further efforts are needed to close the knowledge gap and to understand the burden of pertussis in at-risk adolescent and adult populations to help inform vaccination strategies and recommendations.

Keywords: COPD; Pertussis; asthma; high risk; obesity; smoking.

Figures

Figure 1.
Figure 1.
Flow diagram of studies included in the review n, number of records included in each step of review
Figure 1.
Figure 1.
Flow diagram of studies included in the review n, number of records included in each step of review
Figure 2.
Figure 2.
The most frequent underlying medical conditions in hospitalized pertussis patients by different age groups (Mbayei, Clin Infect Dis 2018) IC, immunocompromising condition; N, number of hospitalized pertussis patients; O RT/PC, other respiratory tract/pulmonary condition; COPD, chronic obstructive pulmonary disease
Figure 2.
Figure 2.
The most frequent underlying medical conditions in hospitalized pertussis patients by different age groups (Mbayei, Clin Infect Dis 2018) IC, immunocompromising condition; N, number of hospitalized pertussis patients; O RT/PC, other respiratory tract/pulmonary condition; COPD, chronic obstructive pulmonary disease
Figure 3.
Figure 3.
Increased risk of pertussis in patients with asthma PCR, polymerase chain reaction; CI, confidence interval
Figure 3.
Figure 3.
Increased risk of pertussis in patients with asthma PCR, polymerase chain reaction; CI, confidence interval
Figure 4.
Figure 4.
Plain language summary
Figure 4.
Figure 4.
Plain language summary

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