Intermittent Theta Burst Stimulation Increases Reward Responsiveness in Individuals with Higher Hedonic Capacity

Romain Duprat, Rudi De Raedt, Guo-Rong Wu, Chris Baeken, Romain Duprat, Rudi De Raedt, Guo-Rong Wu, Chris Baeken

Abstract

Background: Repetitive transcranial magnetic stimulation over the left dorsolateral prefrontal cortex (DLPFC) has been documented to influence striatal and orbitofrontal dopaminergic activity implicated in reward processing. However, the exact neuropsychological mechanisms of how DLPFC stimulation may affect the reward system and how trait hedonic capacity may interact with the effects remains to be elucidated.

Objective: In this sham-controlled study in healthy individuals, we investigated the effects of a single session of neuronavigated intermittent theta burst stimulation (iTBS) on reward responsiveness, as well as the influence of trait hedonic capacity.

Methods: We used a randomized crossover single session iTBS design with an interval of 1 week. We assessed reward responsiveness using a rewarded probabilistic learning task and measured individual trait hedonic capacity (the ability to experience pleasure) with the temporal experience of pleasure scale questionnaire.

Results: As expected, the participants developed a response bias toward the most rewarded stimulus (rich stimulus). Reaction time and accuracy for the rich stimulus were respectively shorter and higher as compared to the less rewarded stimulus (lean stimulus). Active or sham stimulation did not seem to influence the outcome. However, when taking into account individual trait hedonic capacity, we found an early significant increase in the response bias only after active iTBS. The higher the individual's trait hedonic capacity, the more the response bias toward the rich stimulus increased after the active stimulation.

Conclusion: When taking into account trait hedonic capacity, one active iTBS session over the left DLPFC improved reward responsiveness in healthy male participants with higher hedonic capacity. This suggests that individual differences in hedonic capacity may influence the effects of iTBS on the reward system.

Keywords: anhedonia; dorsolateral prefrontal cortex; iTBS; probabilistic learning; reward processing; reward sensitivity; theta burst stimulation.

Figures

Figure 1
Figure 1
Probabilistic reward task schematic design (Pizzagalli et al., 2005).
Figure 2
Figure 2
Representation of the RB across blocks (B1, B2, and B3), before and after (pre, post) active or sham stimulation. Significant effects are marked by *p < 0.05.
Figure 3
Figure 3
Correlations between TEPS CON and ΔRB B2B1 pre/post active, r(19) = 0.41, p = 0.064 (A) and ΔRB B2B1 pre/post active minus the 2 influential cases, r(17) = 0.59, p < 0.01 (B) and between TEPS CON and ΔRB B3B2 pre/post active r(19) = −0.54, p = 0.01 (C) and ΔRB B3B2 pre/post active minus 1 influential case, r(18) = −0.46, p = 0.04 (D). The influential cases are colored in red.

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