The efficacy of transcranial magnetic stimulation on migraine: a meta-analysis of randomized controlled trails

Lihuan Lan, Xiaoni Zhang, Xiangpen Li, Xiaoming Rong, Ying Peng, Lihuan Lan, Xiaoni Zhang, Xiangpen Li, Xiaoming Rong, Ying Peng

Abstract

Objectives: As a non-invasive therapy, whether transcranial magnetic stimulation (TMS) is effective on migraine. This article was aimed to assess the efficacy of TMS on migraine based on randomized controlled trails (RCTs).

Methods: We searched PubMed, Embase and Cochrane Library electronic databases for published studies which compared TMS group with sham group, conducted a meta-analysis of all RCTs.

Results: Five studies, consisting of 313 migraine patients, were identified. Single-pulse transcranial magnetic stimulation is effective for the acute treatment of migraine with aura after the first attack (p = 0.02). And, the efficacy of TMS on chronic migraine was not significant (OR 2.93; 95% CI 0.71-12.15; p = 0.14).

Conclusions: TMS is effective for migraine based on the studies included in the article.

Keywords: Migraine; Randomized control trail; Transcranial magnetic stimulation.

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flow diagram of search strategy
Fig. 2
Fig. 2
Heterogeneity among studies and the effect of TMS on migraine
Fig. 3
Fig. 3
Risk of bias summary of researches included in this meta-analysis
Fig. 4
Fig. 4
a The effect of TMS on migraine with aura. b The effect of TMS on chronic migraine

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