Group treatment for complex dissociative disorders: a randomized clinical trial

Harald Bækkelund, Pål Ulvenes, Suzette Boon-Langelaan, Espen Ajo Arnevik, Harald Bækkelund, Pål Ulvenes, Suzette Boon-Langelaan, Espen Ajo Arnevik

Abstract

Background: Patients with complex dissociative disorders (CDD) report high levels of childhood- abuse experiences, clinical comorbidity, functional impairment, and treatment utilization. Although a few naturalistic studies indicate that these patients can benefit from psychotherapy, no randomized controlled trials have been reported with this patient-group. The current study evaluates a structured protocolled group treatment delivered in a naturalistic clinical setting to patients with CDD, as an add-on to individual treatment.

Methods: Fifty nine patients with CDD were randomized to 20 sessions of stabilizing group-treatment, conjoint with individual therapy, or individual therapy alone, in a delayed-treatment design. The treatment was based on the manual Coping with Trauma-Related Dissociation. The primary outcome was Global Assessment of Functioning (GAF), while secondary outcomes were PTSD and dissociative symptoms, general psychopathology, and interpersonal difficulties.

Results: Mixed effect models showed no condition x time interaction during the delayed treatment period, indicating no immediate differences between conditions in the primary outcome. Similar results were observed for secondary outcomes. Within-group effects were non-significant in both conditions from baseline to end of treatment, but significant improvements in psychosocial function, PTSD symptoms, and general psychopathology were observed over a 6-months follow-up period.

Conclusion: In the first randomized controlled trial for the treatment of complex dissociative disorders, stabilizing group treatment did not produce immediate superior outcomes. Treatment was shown to be associated with improvements in psychological functioning.

Trial registration: Clinical Trials ( NCT02450617 ).

Keywords: Dissociative disorders; Group psychotherapy; Psychological trauma; Psychotherapy outcome research; Randomized clinical trial.

Conflict of interest statement

SB is the first author of the treatment manual of the study and receives royalty from W. W. Norton & Company. She also received consultation fees for trainings in the use of the manual and treatment of dissociative disorders.

The other authors have no conflicts of interest to declare.

© 2022. The Author(s).

Figures

Fig. 1
Fig. 1
Flow-diagram of a randomized controlled trial of group treatment for complex dissociative disorders
Fig. 2
Fig. 2
Illustration of study design combining a randomized trial with a delayed treatment control group and multiple time series with switching replication
Fig. 3
Fig. 3
Global Assessment of Functioning across a randomized trial with delayed treatment control

References

    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders: DSM-5. American Psychiatric Association; 2013. p. 991.
    1. Dell PF. Understanding dissociation. Dissociation and the dissociative disorders: DSM-V and beyond. New York: Routledge; 2009. pp. 709–825.
    1. Spiegel D, Lewis-Fernández R, Lanius R, Vermetten E, Simeon D, Friedman M. Dissociative disorders in DSM-5. Annu Rev Clin Psychol. 2013;9:299–326. doi: 10.1146/annurev-clinpsy-050212-185531.
    1. Bækkelund H, Frewen P, Lanius R, Ottesen Berg A, Arnevik EA. Trauma-related altered states of consciousness in post-traumatic stress disorder patients with or without comorbid dissociative disorders. Eur J Psychotraumatol. 2018;9(1):1544025. doi: 10.1080/20008198.2018.1544025.
    1. Boon S, Draijer N. Multiple personality disorder in The Netherlands: a clinical investigation of 71 patients. Am J Psychiatry. 1993;150(3):489–494. doi: 10.1176/ajp.150.3.489.
    1. Foote B, Smolin Y, Neft DI, Lipschitz D. Dissociative disorders and suicidality in psychiatric outpatients. J Nerv Ment Dis. 2008;196(1):29–36. doi: 10.1097/NMD.0b013e31815fa4e7.
    1. Mueller-Pfeiffer C, Rufibach K, Perron N, Wyss D, Kuenzler C, Prezewowsky C, et al. Global functioning and disability in dissociative disorders. Psychiatry Res. 2012;200(2–3):475–481. doi: 10.1016/j.psychres.2012.04.028.
    1. Rodewald F, Wilhelm-Göling C, Emrich HM, Reddemann L, Gast U. Axis-I comorbidity in female patients with dissociative identity disorder and dissociative identity disorder not otherwise specified. J Nerv Ment Dis. 2011;199(2):122–131. doi: 10.1097/NMD.0b013e318208314e.
    1. Sar V. Epidemiology of Dissociative Disorders: An Overview. Epidemiol Res Int. 2011;2011:1–8. doi: 10.1155/2011/404538.
    1. Dalenberg CJ, Brand BL, Gleaves DH, Dorahy MJ, Loewenstein RJ, Cardeña E, et al. Evaluation of the evidence for the trauma and fantasy models of dissociation. Psychol Bull. 2012;138(3):550–588. doi: 10.1037/a0027447.
    1. Brown RJ. Different types of “dissociation” have different psychological mechanisms. J Trauma Dissoc. 2006;7(4):7–28. doi: 10.1300/J229v07n04_02.
    1. International Society for the Study Guidelines for Treating Dissociative Identity Disorder in Adults, Third Revision. J Trauma Dissoc. 2011;12(2):115–187. doi: 10.1080/15299732.2011.537247.
    1. Lilienfeld SO. Psychological treatments that cause harm. Perspect Psychol Sci. 2007;2(1):53–70. doi: 10.1111/j.1745-6916.2007.00029.x.
    1. Lynn SJ, Lilienfeld SO, Merckelbach H, Giesbrecht T, van der Kloet D. Dissociation and Dissociative Disorders: Challenging Conventional Wisdom. Curr Dir Psychol Sci. 2012;21(1):48–53. doi: 10.1177/0963721411429457.
    1. Paris J. The rise and fall of dissociative identity disorder. J Nerv Ment Dis. 2012;200(12):1076–1079. doi: 10.1097/NMD.0b013e318275d285.
    1. Loewenstein RJ. Dissociation debates: everything you know is wrong. Dialogues Clin Neurosci. 2018;20(3):229–242. doi: 10.31887/DCNS.2018.20.3/rloewenstein.
    1. Brand BL, Classen CC, McNary SW, Zaveri P. A review of dissociative disorders treatment studies. J Nerv Ment Dis. 2009;197(9):646–654. doi: 10.1097/NMD.0b013e3181b3afaa.
    1. Jepsen EKK, Langeland W, Sexton H, Heir T. Inpatient Treatment for Early Sexually Abused Adults: A Naturalistic 12-Month Follow-Up Study. Psychol Trauma Theory Res Pract Policy. 2014. 10.1037/a0031646.
    1. Brand B, Classen C, Lanins R, Loewenstein R, McNary S, Pain C, et al. A naturalistic study of dissociative identity disorder and dissociative disorder not otherwise specified patients treated by community clinicians. Psychol Trauma Theory Res Pract Policy. 2009;1(2):153–171. doi: 10.1037/a0016210.
    1. Brand BL, McNary SW, Myrick AC, Classen CC, Lanius R, Loewenstein RJ, et al. A longitudinal naturalistic study of patients with dissociative disorders treated by community clinicians. Psychol Trauma Theory Res Pract Policy. 2013;5(4):301–308. doi: 10.1037/a0027654.
    1. Myrick AC, Webermann AR, Loewenstein RJ, Lanius R, Putnam FW, Brand BL. Six-year follow-up of the treatment of patients with dissociative disorders study*. Eur J Psychotraumatol. 2017;8(1):1344080. doi: 10.1080/20008198.2017.1344080.
    1. Myrick AC, Webermann AR, Langeland W, Putnam FW, Brand BL. Treatment of dissociative disorders and reported changes in inpatient and outpatient cost estimates. Eur J Psychotraumatol. 2017;8(1):1375829. doi: 10.1080/20008198.2017.1375829.
    1. Myrick AC, Chasson GS, Lanius RA, Leventhal B, Brand BL. Treatment of Complex Dissociative Disorders: A Comparison of Interventions Reported by Community Therapists versus Those Recommended by Experts. J Trauma Dissoc. 2015;16(1):51–67. doi: 10.1080/15299732.2014.949020.
    1. Brand BL, Schielke HJ, Putnam KT, Putnam FW, Loewenstein RJ, Myrick A, et al. An Online Educational Program for Individuals With Dissociative Disorders and Their Clinicians: 1-Year and 2-Year Follow-Up: Online Intervention for Dissociative Disorders. J Trauma Stress. 2019;32(1):156–166. doi: 10.1002/jts.22370.
    1. Boon S, Steele K, van der Hart O. Coping with Trauma-Related Dissociation: Skills Training for Patients and Therapists. W. W. Norton & Company; 2011.
    1. van der Hart O, Nijenhuis ERS, Steele K. The Haunted Self: Structural Dissociation and the Treatment of Chronic Traumatization (Norton Series on Interpersonal Neurobiology) W W Norton & Company; 2006.
    1. Nijenhuis ERS, van der Hart O. Dissociation in trauma: a new definition and comparison with previous formulations. J Trauma Dissoc. 2011;12(4):416–445. doi: 10.1080/15299732.2011.570592.
    1. Steinberg M, Cicchetti D, Buchanan J, Hall P. Clinical assessment of dissociative symptoms and disorders: The Structured Clinical Interview for DSM-IV Dissociative Disorders (SCID-D) Dissoc Progress Dissoci Disord. 1993;6(1):3–15.
    1. Dell PF. The multidimensional inventory of dissociation (MID): A comprehensive measure of pathological dissociation. J Trauma Dissoc. 2006;7(2):77–106. doi: 10.1300/J229v07n02_06.
    1. Foa EB, Riggs DS, Dancu CV, Rothbaum BO. Reliability and validity of a brief instrument for assessing post-traumatic stress disorder. J Trauma Stress. 1993;6(4):459–473. doi: 10.1002/jts.2490060405.
    1. Foa EB, Tolin DF. Comparison of the PTSD Symptom Scale-Interview Version and the Clinician-Administered PTSD scale. J Trauma Stress. 2000;13(2):181–191. doi: 10.1023/A:1007781909213.
    1. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59 Suppl 2:22–33.
    1. Mordal J, Gundersen Ø, Bramness JG. Norwegian version of the Mini-International Neuropsychiatric Interview: Feasibility, acceptability and test-retest reliability in an acute psychiatric ward. Eur Psychiatry. 2010;25(3):172–177. doi: 10.1016/j.eurpsy.2009.02.004.
    1. Bernstein DP, Fink L, Handelsman L, Foote J, Lovejoy M, Wenzel K, et al. Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am J Psychiatry. 1994;151(8):1132–1136. doi: 10.1176/ajp.151.8.1132.
    1. Dovran A, Winje D, Overland SN, Breivik K, Arefjord K, Dalsbø AS, et al. Psychometric properties of the Norwegian version of the Childhood Trauma Questionnaire in high-risk groups. Scand J Psychol. 2013;54(4):286–291. doi: 10.1111/sjop.12052.
    1. Karterud S, Pedersen G, Loevdahl H, Friis S. Global Assessment of Functioning–Split version (S-GAF): background and scoring manual. Psychiatry Clinic, Ullevål Hospital. Oslo; 1998. .
    1. Støre-Valen J, Ryum T, Pedersen GAF, Pripp AH, Jose PE, Karterud S. Does a Web-Based Feedback Training Program Result in Improved Reliability in Clinicians’ Ratings of the Global Assessment of Functioning (GAF) Scale? Psychol Assess. 2015;27(3):No Pagination Specified. doi: 10.1037/pas0000086.
    1. Pedersen G, Hagtvet KA, Karterud S. Generalizability studies of the Global Assessment of Functioning-Split version. Compr Psychiatry. 2007;48(1):88–94. doi: 10.1016/j.comppsych.2006.03.008.
    1. Coffey SF, Gudmundsdottir B, Beck JG, Palyo SA, Miller L. Screening for PTSD in motor vehicle accident survivors using the PSS-SR and IES. J Trauma Stress. 2006;19(1):119–128. doi: 10.1002/jts.20106.
    1. Derogatis LR, Unger R. Symptom Checklist-90-Revised. In: The Corsini Encyclopedia of Psychology. Wiley, Ltd; 2010. p. 1–2. Available at:.
    1. Siqveland J, Moum T, Leiknes K. Måleegenskaper ved den norske versjonen av Symptom Checklist 90 Revidert (SCL-90-R) Oslo: Folkehelseinstituttet; 2016.
    1. Horowitz L, Alden L, Wiggins J, Pincus A. Inventory of Interpersonal Problems Manual. San Antonio: The Psychological Corporation; 2000.
    1. Monsen JT, Hagtvet KA, Havik OE, Eilertsen DE. Circumplex structure and personality disorder correlates of the Interpersonal Problems model (IIP-C): construct validity and clinical implications. Psychol Assess. 2006;18(2):165–173. doi: 10.1037/1040-3590.18.2.165.
    1. Bernstein EM, Putnam FW. Development, reliability, and validity of a dissociation scale. J Nerv Ment Dis. 1986;174(12):727–735. doi: 10.1097/00005053-198612000-00004.
    1. Carlson E, Putnam F. An update on the dissociative experiences scale. Dissoc Progress Dissoci Disord. 1993;6(1):16–27.
    1. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Elsevier; 1977.
    1. Fitzmaurice GM, Laird NM, Ware JH. Applied Longitudinal Analysis. 2. Wiley; 2012.
    1. Brand BL, Loewenstein RJ, Spiegel D. Dispelling myths about dissociative identity disorder treatment: an empirically based approach. Psychiatry. 2014;77(2):169–189. doi: 10.1521/psyc.2014.77.2.169.
    1. De Jongh A, Resick PA, Zoellner LA, van Minnen A, Lee CW, Monson CM, et al. Critical Analysis of the Current Treatment Guidelines for Complex Ptsd in Adults. Depress Anxiety. 2016;11(April 2015):359–369. doi: 10.1002/da.22469.
    1. Huntjens RJC, Rijkeboer MM, Arntz A. Schema therapy for Dissociative Identity Disorder (DID): further explanation about the rationale and study protocol. Eur J Psychotraumatol. 2019;10(1). 10.1080/20008198.2019.1684629.
    1. Huntjens RJC, Rijkeboer MM, Arntz A. Schema therapy for Dissociative Identity Disorder (DID): rationale and study protocol. Eur J Psychotraumatol. 2019;10(1). 10.1080/20008198.2019.1571377.
    1. Mohajerin B, Lynn SJ, Bakhtiyari M, Dolatshah B. Evaluating the Unified Protocol in the Treatment of Dissociative Identify Disorder. Cogn Behav Pract. 2020;27(3):270–289. doi: 10.1016/j.cbpra.2019.07.012.
    1. Stadtmann MP, Maercker A, Binder J, Schnepp W. Why do I have to suffer? Symptom management, views and experiences of persons with a CPTSD: a grounded theory approach. BMC Psychiatry. 2018;18(1):392. doi: 10.1186/s12888-018-1971-9.
    1. Schielke H, Brand B, Marsic A. Assessing therapeutic change in patients with severe dissociative disorders: the progress in treatment questionnaire, therapist and patient measures. Eur J Psychotraumatol. 2017;8(1). 10.1080/20008198.2017.1380471.

Source: PubMed

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