Prevention of serious respiratory syncytial virus-related illness. I: Disease pathogenesis and early attempts at prevention

Jessie R Groothuis, J Michael Hoopes, Val G Hemming Jessie, Jessie R Groothuis, J Michael Hoopes, Val G Hemming Jessie

Abstract

Respiratory syncytial virus (RSV) was first described 160 years ago but was not officially recognized as a cause of serious illness in children until the late 1950s. It has been estimated that virtually all children have had at least one RSV infection by their second birthday. RSV is responsible for annual disease outbreaks, usually during a defined winter seasonal period that can vary by community and year. RSV is recognized as the leading cause of hospitalization among young children worldwide. Infants of young chronologic age and children with predisposing factors, such as premature birth, pulmonary disease, or congenital heart disease, are most susceptible to serious illness. Unlike other viruses, immunity to RSV infection is incomplete and short lived, and reinfection is common throughout life. Initial attempts to develop a vaccine in the 1960s met with unexpected and tragic results; many children vaccinated with a formalin-inactivated wild-type virus developed serious pulmonary disease upon subsequent natural infection. Numerous other vaccine technologies have since been studied, including vectored approaches, virus-like particles, DNA vaccines, and live attenuated virus vaccine. As of early 2010, only two companies or institutions had RSV vaccine candidates in early clinical trials, and no vaccine is likely to be licensed for marketing in the immediate future.

References

    1. Hall C.B. Respiratory syncytial virus. In: Feigen R.D., Cherry J.D., editors. Textbook of Pediatric Infectious Diseases. Philadelphia, PA: WB Saunders; 1987. pp. 1653–1675.
    1. Hall C.B. Respiratory syncytial virus and parainfluenza virus. N Engl J Med. 2001;344:1917–1928. doi: 10.1056/NEJM200106213442507.
    1. Hall C.B., Weinberg G.A., Iwane M.K., et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2009;360:588–598. doi: 10.1056/NEJMoa0804877.
    1. Leader S., Kohlhase K. Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999. Pediatr Infect Dis J. 2002;21:629–632. doi: 10.1097/00006454-200207000-00005.
    1. Ruuskanen O., Ogra P.L. Respiratory syncytial virus. Curr Probl Pediatr. 1993;23:50–79. doi: 10.1016/0045-9380(93)90003-U.
    1. Shay D.K., Holman R.C., Newman R.D., Liu L.L., Stout J.W., Anderson L.J. Bronchiolitis-associated hospitalizations among US children, 1980–1996. JAMA. 1999;282:1440–1446. doi: 10.1001/jama.282.15.1440.
    1. Leader S., Kohlhase K. Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000. J Pediatr. 2003;143:S127–132.
    1. McLaurin K, Leader S. Growing impact of RSV hospitalizations among infants in the US, 1997–2002. Paper presented at: Pediatric Academic Societies’ Meeting; May 14–17, 2005; Washington, DC, USA.
    1. Nair H., Nokes D.J., Gessner B.D., et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375:1545–1555. doi: 10.1016/S0140-6736(10)60206-1.
    1. Carroll K.N., Gebretsadik T., Griffin M.R., et al. Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan. Pediatrics. 2008;122:58–64. doi: 10.1542/peds.2007-2087.
    1. Forbes M.L., Hall C.B., Jackson A., Masaquel A.S., Mahadevia P.J. Comparative costs of hospitalisation among infants at high risk for respiratory syncytial virus lower respiratory tract infection during the first year of life. J Med Econ. 2010;13:136–141. doi: 10.3111/13696990903583404.
    1. Ruotsalainen M., Piippo-Savolainen E., Hyvarinen M.K., Korppi M. Respiratory morbidity in adulthood after respiratory syncytial virus hospitalization in infancy. Pediatr Infect Dis J. 2010;29:872–874. doi: 10.1097/INF.0b013e3181dea5de.
    1. Stein R.T., Sherrill D., Morgan W.J., et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354:541–545. doi: 10.1016/S0140-6736(98)10321-5.
    1. Sigurs N., Aljassim F., Kjellman B., et al. Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax. 2010;65:1045–1052. doi: 10.1136/thx.2009.121582.
    1. Eberle J. A Treatise on the Diseases and Physical Education of Children. Philadelphia, PA: Lippincott, Grambo and Co.; 1850.
    1. Adams J.M. Primary virus pneumonitis with cytoplasmic inclusion bodies: study of an epidemic involving thirty-two infants, with nine deaths. JAMA. 1941;116:925–933.
    1. Adams J.M., Green R.G., Evans C.A., Northrop B. Primary virus pneumonitis: a comparative study of two epidemics. J Pediatr. 1942;20:405–420. doi: 10.1016/S0022-3476(42)80256-5.
    1. Blount R.E., Jr, Morris J.A., Savage R.E. Recovery of cytopathogenic agent from chimpanzees with coryza. Proc Soc Exp Biol Med. 1956;92:544–549.
    1. Chanock R., Finberg L. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). II. Epidemiologic aspects of infection in infants and young children. Am J Hyg. 1957;66:291–300.
    1. Chanock R., Roizman B., Myers R. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). I. Isolation, properties and characterization. Am J Hyg. 1957;66:281–290.
    1. Chin J., Magoffin R.L., Shearer L.A., Schieble J.H., Lennette E.H. Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol. 1969;89:449–463.
    1. Fulginiti V.A., Eller J.J., Sieber O.F., Joyner J.W., Minamitani M., Meiklejohn G. Respiratory virus immunization. I. A field trial of two inactivated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccine. Am J Epidemiol. 1969;89:435–448.
    1. Kapikian A.Z., Mitchell R.H., Chanock R.M., Shvedoff R.A., Stewart C.E. An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am J Epidemiol. 1969;89:405–421.
    1. Kim H.W., Canchola J.G., Brandt C.D., et al. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 1969;89:422–434.
    1. Dreizin R.S., Vyshnevetskaia L.O., Bagdamian E.E., Iankevich O.D., Tarasova L.B. Experimental RS virus infection of cotton rats. A viral and immunofluorescent study [in Russian] Vopr Virusol. 1971;16:670–676.
    1. Prince G.A., Jenson A.B., Horswood R.L., Camargo E., Chanock R.M. The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol. 1978;93:771–791.
    1. Prince G.A., Horswood R.L., Camargo E., Koenig D., Chanock R.M. Mechanisms of immunity to respiratory syncytial virus in cotton rats. Infect Immun. 1983;42:81–87.
    1. Belshe R.B., Van Voris L.P., Mufson M.A. Parenteral administration of live respiratory syncytial virus vaccine: results of a field trial. J Infect Dis. 1982;145:311–319. doi: 10.1093/infdis/145.3.311.
    1. Hemming V.G., Rodriguez W., Kim H.W., et al. Intravenous immunoglobulin treatment of respiratory syncytial virus infections in infants and young children. Antimicrob Agents Chemother. 1987;31:1882–1886.
    1. Groothuis J.R., Levin M.J., Rodriguez W., et al. Use of intravenous gamma globulin to passively immunize high-risk children against respiratory syncytial virus: safety and pharmacokinetics. The RSVIG Study Group. Antimicrob Agents Chemother. 1991;35:1469–1473.
    1. Meissner H.C., Fulton D.R., Groothuis J.R., et al. Controlled trial to evaluate protection of high-risk infants against respiratory syncytial virus disease by using standard intravenous immune globulin. Antimicrob Agents Chemother. 1993;37:1655–1658.
    1. Belshe R.B., Anderson E.L., Walsh E.E. Immunogenicity of purified F glycoprotein of respiratory syncytial virus: clinical and immune responses to subsequent natural infection in children. J Infect Dis. 1993;168:1024–1029. doi: 10.1093/infdis/168.4.1024.
    1. Tristram D.A., Welliver R.C., Mohar C.K., Hogerman D.A., Hildreth S.W., Paradiso P. Immunogenicity and safety of respiratory syncytial virus subunit vaccine in seropositive children 18–36 months old. J Infect Dis. 1993;167:191–195. doi: 10.1093/infdis/167.1.191.
    1. Falsey A.R., Walsh E.E. Safety and immunogenicity of a respiratory syncytial virus subunit vaccine (PFP-2) in ambulatory adults over age 60. Vaccine. 1996;14:1214–1218. doi: 10.1016/S0264-410X(96)00030-8.
    1. Groothuis J.R., King S.J., Hogerman D.A., Paradiso P.R., Simoes E.A. Safety and immunogenicity of a purified F protein respiratory syncytial virus (PFP-2) vaccine in seropositive children with bronchopulmonary dysplasia. J Infect Dis. 1998;177:467–469. doi: 10.1086/517377.
    1. Piedra P.A., Grace S., Jewell A., et al. Sequential annual administration of purified fusion protein vaccine against respiratory syncytial virus in children with cystic fibrosis. Pediatr Infect Dis J. 1998;17:217–224. doi: 10.1097/00006454-199803000-00009.
    1. Power U.F., Nguyen T.N., Rietveld E., et al. Safety and immunogenicity of a novel recombinant subunit respiratory syncytial virus vaccine (BBG2Na) in healthy young adults. J Infect Dis. 2001;184:1456–1460. doi: 10.1086/324426.
    1. Munoz F.M., Piedra P.A., Glezen W.P. Safety and immunogenicity of respiratory syncytial virus purified fusion protein-2 vaccine in pregnant women. Vaccine. 2003;21:3465–3467. doi: 10.1016/S0264-410X(03)00352-9.
    1. Groothuis J.R., Simoes E.A., Levin M.J., et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. The Respiratory Syncytial Virus Immune Globulin Study Group. N Engl J Med. 1993;329:1524–1530. doi: 10.1056/NEJM199311183292102.
    1. The PREVENT Study Group. Reduction of respiratory syncytial virus hospitalization among premature infants and infants with bronchopulmonary dysplasia using respiratory syncytial virus immune globulin prophylaxis. Pediatrics. 1997;99:93–99. doi: 10.1542/peds.99.1.93.
    1. Simoes E.A., Sondheimer H.M., Top F.H., Jr, et al. Respiratory syncytial virus immune globulin for prophylaxis against respiratory syncytial virus disease in infants and children with congenital heart disease. The Cardiac Study Group. J Pediatr. 1998;133:492–499.
    1. The IMpact-RSV Study Group. Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics. 1998;102:531–537. doi: 10.1542/peds.102.3.531.
    1. OraVax Reports Results from Phase III Trial of HNK20. Nosedrop for Respiratory Syncytial Virus in Infants [press release] Cambridge (MA): OraVax; 1997.
    1. Meissner H.C., Groothuis J.R., Rodriguez W.J., et al. Safety and pharmacokinetics of an intramuscular monoclonal antibody (SB 209763) against respiratory syncytial virus (RSV) in infants and young children at risk for severe RSV disease. Antimicrob Agents Chemother. 1999;43:1183–1188.
    1. Rodriguez W.J., Gruber W.C., Welliver R.C., et al. Respiratory syncytial virus (RSV) immune globulin intravenous therapy for RSV lower respiratory tract infection in infants and young children at high risk for severe RSV infections: Respiratory Syncytial Virus Immune Globulin Study Group. Pediatrics. 1997;99:454–461. doi: 10.1542/peds.99.3.454.
    1. Feltes T.F., Cabalka A.K., Meissner H.C., et al. Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease. J Pediatr. 2003;143:532–540. doi: 10.1067/S0022-3476(03)00454-2.
    1. Carbonell-Estrany X., Simoes E.A., Dagan R., et al. Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority trial. Pediatrics. 2010;125:e35–51. doi: 10.1542/peds.2008-1036.
    1. Feltes TF, Sondheimer HM, Harris BS, et al. A randomized controlled trial of RSV prophylaxis with motavizumab vs palivizumab in young children with hemodynamically significant congenital heart disease (CHD). Paper presented at: Pediatric Academic Societies Annual Meeting; May 1–4, 2010; Vancouver, BC, Canada.
    1. Chandran A, Millar EV, Weatherholtz R, et al. Safety and efficacy of motavizumab in the prevention of RSV disease in healthy infants. Paper presented at: American Pediatric Society/77th Annual Meeting for the Society for Pediatric Research; May 4, 2008; Honolulu, HI, USA.
    1. Beem M., Wright F.H., Hamre D., Egerer R., Oehme M. Association of the chimpanzee coryza agent with acute respiratory disease in children. N Engl J Med. 1960;263:523–530. doi: 10.1056/NEJM196009152631101.
    1. Chanock R.M., Kim H.W., Vargosko A.J., et al. Respiratory syncytial virus. I. Virus recovery and other observations during 1960 outbreak of bronchiolitis, pneumonia, and minor respiratory diseases in children. JAMA. 1961;176:647–653.
    1. Parrott R.H., Vargosko A.J., Kim H.W., et al. Respiratory syncytial virus. II. Serologic studies over a 34-month period of children with bronchiolitis, pneumonia, and minor respiratory diseases. JAMA. 1961;176:653–657.
    1. Adams J.M., Imagawa D.T., Zike K. Epidemic bronchiolitis and pneumonitis related to respiratory syncytial virus. JAMA. 1961;176:1037–1039.
    1. Hamparian V.V., Ketler A., Hilleman M.R., et al. Studies of acute respiratory illnesses caused by respiratory syncytial virus. 1. Laboratory findings in 109 cases. Proc Soc Exp Biol Med. 1961;106:717–722.
    1. Kapikian A.Z., Bell J.A., Mastrota F.M., Johnson K.M., Huebner R.J., Chanock R.M. An outbreak of febrile illness and pneumonia associated with respiratory syncytial virus infection. Am J Hyg. 1961;74:234–248.
    1. Peacock D.B., Clarke S.K. Respiratory syncytial virus in Britain. Lancet. 1961;ii:466. doi: 10.1016/S0140-6736(61)92435-7.
    1. Rowe D.S., Michaels R.H. Isolation of the respiratory syncytial virus from a patient with pneumonia. Pediatrics. 1960;26:623–629.
    1. Chanock R.M., Parrott R.H., Vargosko A.J., Kapikian A.Z., Knight V., Johnson K.M. Acute respiratory diseases of viral etiology. IV. Respiratory syncytial virus. Am J Public Health Nations Health. 1962;52:918–925. doi: 10.2105/AJPH.52.6.918.
    1. Beem M. Repeated infections with respiratory syncytial virus. J Immunol. 1967;98:1115–1122.
    1. Glezen W.P., Taber L.H., Frank A.L., Kasel J.A. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child. 1986;140:543–546.
    1. Hall C.B., Walsh E.E., Long C.E., Schnabel K.C. Immunity to and frequency of reinfection with respiratory syncytial virus. J Infect Dis. 1991;163:693–698. doi: 10.1093/infdis/163.4.693.
    1. Henderson F.W., Collier A.M., Clyde W.A., Jr, Denny F.W. Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young children. N Engl J Med. 1979;300:530–534. doi: 10.1056/NEJM197903083001004.
    1. Bruhn F.W., Yeager A.S. Respiratory syncytial virus in early infancy. Circulating antibody and the severity of infection. Am J Dis Child. 1977;131:145–148.
    1. Kasel J.A., Walsh E.E., Frank A.L., Baxter B.D., Taber L.H., Glezen W.P. Relation of serum antibody to glycoproteins of respiratory syncytial virus with immunity to infection in children. Viral Immunol. 1987;1:199–205. doi: 10.1089/vim.1987.1.199.
    1. Lamprecht C.L., Krause H.E., Mufson M.A. Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus. J Infect Dis. 1976;134:211–217. doi: 10.1093/infdis/134.3.211.
    1. Ogilvie M.M., Vathenen A.S., Radford M., Codd J., Key S. Maternal antibody and respiratory syncytial virus infection in infancy. J Med Virol. 1981;7:263–271. doi: 10.1002/jmv.1890070403.
    1. Parrott R.H., Kim H.W., Arrobio J.O., et al. Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. Am J Epidemiol. 1973;98:289–300.
    1. Welliver R.C. Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection. J Pediatr. 2003;143:S112–117. doi: 10.1067/S0022-3476(03)00508-0.
    1. Committee on Infectious Diseases. Modified 69. recommendations for use of palivizumab for prevention of respiratory syncytial virus infections. Pediatrics. 2009;124:1694–1701. doi: 10.1542/peds.2009-2345.
    1. Makari D., Groothuis J. Health risks of the late-preterm infant. Neonatol Today. 2009;4:1–8. doi: 10.1016/j.nantod.2008.10.016.
    1. Engle W.A., Tomashek K.M., Wallman C. “Late-71. preterm” infants: a population at risk. Pediatrics. 2007;120:1390–1401. doi: 10.1542/peds.2007-2952.
    1. Boyce T.G., Mellen B.G., Mitchel E.F., Jr, Wright P.F., Griffin M.R. Rates of hospitalization for respiratory syncytial virus infection among children in Medicaid. J Pediatr. 2000;137:865–870. doi: 10.1067/mpd.2000.110531.
    1. Colin A.A., McEvoy C., Castile R. Respiratory morbidity and lung function in preterm infants of 32 to 36 weeks’ gestational age. Pediatrics. 2010;126:115–128. doi: 10.1542/peds.2009-1381.
    1. Law B.J., MacDonald N., Langley J., et al. Severe respiratory syncytial virus infection among otherwise healthy prematurely born infants: What are we trying to prevent? Paediatr Child Health. 1998;3:402–404.
    1. Willson D.F., Landrigan C.P., Horn S.D., Smout R.J. Complications in infants hospitalized for bronchiolitis or respiratory syncytial virus pneumonia. J Pediatr. 2003;143:S142–149. doi: 10.1067/S0022-3476(03)00514-6.
    1. Groothuis J.R., Gutierrez K.M., Lauer B.A. Respiratory syncytial virus infection in children with bronchopulmonary dysplasia. Pediatrics. 1988;82:199–203.
    1. MacDonald N.E., Hall C.B., Suffin S.C., Alexson C., Harris P.J., Manning J.A. Respiratory syncytial viral infection in infants with congenital heart disease. N Engl J Med. 1982;307:397–400. doi: 10.1056/NEJM198208123070702.
    1. Navas L., Wang E., de Carvalho V., Robinson J. Improved outcome of respiratory syncytial virus infection in a high-risk hospitalized population of Canadian children. Pediatric Investigators Collaborative Network on Infections in Canada. J Pediatr. 1992;121:348–354. doi: 10.1016/S0022-3476(05)90000-0.
    1. Panitch H.B. Viral respiratory infections in children with technology dependence and neuromuscular disorders. Pediatr Infect Dis J. 2004;23:S222–227. doi: 10.1097/01.inf.0000144670.78558.c7.
    1. Wilkesmann A., Ammann R.A., Schildgen O., et al. Hospitalized children with respiratory syncytial virus infection and neuromuscular impairment face an increased risk of a complicated course. Pediatr Infect Dis J. 2007;26:485–491. doi: 10.1097/INF.0b013e31805d01e3.
    1. Carbonell-Estrany X., Quero J. Hospitalization rates for respiratory syncytial virus infection in premature infants born during two consecutive seasons. Pediatr Infect Dis J. 2001;20:874–879. doi: 10.1097/00006454-200109000-00010.
    1. Figueras-Aloy J., Carbonell-Estrany X., Quero J. Case-control study of the risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born at a gestational age of 33–35 weeks in Spain. Pediatr Infect Dis J. 2004;23:815–820. doi: 10.1097/01.inf.0000136869.21397.6b.
    1. Simoes E.A. Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease. J Pediatr. 2003;143:S118–126. doi: 10.1067/S0022-3476(03)00511-0.
    1. McConnochie K.M., Roghmann K.J. Parental smoking, presence of older siblings, and family history of asthma increase risk of bronchiolitis. Am J Dis Child. 1986;140:806–812.
    1. von Linstow M.L., Hogh M., Nordbo S.A., Eugen-Olsen J., Koch A., Hogh B. A community study of clinical traits and risk factors for human metapneumovirus and respiratory syncytial virus infection during the first year of life. Eur J Pediatr. 2008;167:1125–1133. doi: 10.1007/s00431-007-0643-4.
    1. Lanari M., Giovannini M., Giuffre L., et al. Prevalence of respiratory syncytial virus infection in Italian infants hospitalized for acute lower respiratory tract infections, and association between respiratory syncytial virus infection risk factors and disease severity. Pediatr Pulmonol. 2002;33:458–465. doi: 10.1002/ppul.10047.
    1. Resch B., Manzoni P., Lanari M. Severe respiratory syncytial virus (RSV) infection in infants with neuromuscular diseases and immune deficiency syndromes. Paediatr Respir Rev. 2009;10:148–153. doi: 10.1016/j.prrv.2009.06.003.
    1. Resch B., Pasnocht A., Gusenleitner W., Muller W. Rehospitalisations for respiratory disease and respiratory syncytial virus infection in preterm infants of 29–36 weeks gestational age. J Infect. 2005;50:397–403. doi: 10.1016/j.jinf.2004.06.015.
    1. Simoes E.A., King S.J., Lehr M.V., Groothuis J.R. Preterm twins and triplets. A high-risk group for severe respiratory syncytial virus infection. Am J Dis Child. 1993;147:303–306.
    1. Collins P.L., Graham B.S. Viral and host factors in human respiratory syncytial virus pathogenesis. J Virol. 2008;82:2040–2055. doi: 10.1128/JVI.01625-07.
    1. Yeung C.Y., Hobbs J.R. Serum-gamma-G-globulin levels in normal premature, post-mature, and “small-for-dates” newborn babies. Lancet. 1968;i:1167–1170. doi: 10.1016/S0140-6736(68)91865-5.
    1. Ballow M., Cates K.L., Rowe J.C., Goetz C., Desbonnet C. Development of the immune system in very low birth weight (less than 1500 g) premature infants: concentrations of plasma immunoglobulins and patterns of infections. Pediatr Res. 1986;20:899–904. doi: 10.1203/00006450-198609000-00019.
    1. Brandenburg A.H., Groen J., van Steensel-Moll H.A., et al. Respiratory syncytial virus specific serum antibodies in infants under six months of age: limited serological response upon infection. J Med Virol. 1997;52:97–104. doi: 10.1002/(SICI)1096-9071(199705)52:1<97::AID-JMV16>;2-Y.
    1. Hacimustafaoglu M., Celebi S., Aynaci E., et al. The progression of maternal RSV antibodies in the offspring. Arch Dis Child. 2004;89:52–53. doi: 10.1136/adc.2002.017780.
    1. Ochola R., Sande C., Fegan G., et al. The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya. PLoS ONE. 2009;4:e8088. doi: 10.1371/journal.pone.0008088.
    1. Murphy B.R., Alling D.W., Snyder M.H., et al. Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection. J Clin Microbiol. 1986;24:894–898.
    1. Murphy B.R., Prince G.A., Walsh E.E., et al. Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine. J Clin Microbiol. 1986;24:197–202.
    1. Murphy B.R., Walsh E.E. Formalin-inactivated respiratory syncytial virus vaccine induces antibodies to the fusion glycoprotein that are deficient in fusion-inhibiting activity. J Clin Microbiol. 1988;26:1595–1597.
    1. Blanco JC, Boukhvalova MS, Shirey KA, Prince GA, Vogel SN. New insights for development of a safe and protective RSV vaccine. Hum Vaccin. 2010;6.
    1. Castilow E.M., Varga S.M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination. Future Virol. 2008;3:445–454. doi: 10.2217/17460794.3.5.445.
    1. Delgado M.F., Coviello S., Monsalvo A.C., et al. Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease. Nat Med. 2009;15:34–41. doi: 10.1038/nm.1894.
    1. Haynes L.M., Jones L.P., Barskey A., Anderson L.J., Tripp R.A. Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P. J Virol. 2003;77:9831–9844. doi: 10.1128/JVI.77.18.9831-9844.2003.
    1. Johnson T.R., Teng M.N., Collins P.L., Graham B.S. Respiratory syncytial virus (RSV) G glycoprotein is not necessary for vaccine-enhanced disease induced by immunization with formalin-inactivated RSV. J Virol. 2004;78:6024–6032. doi: 10.1128/JVI.78.11.6024-6032.2004.
    1. Ponnuraj E.M., Hayward A.R., Raj A., Wilson H., Simoes E.A. Increased replication of respiratory syncytial virus (RSV) in pulmonary infiltrates is associated with enhanced histopathological disease in bonnet monkeys (Macaca radiata) pre-immunized with a formalin-inactivated RSV vaccine. J Gen Virol. 2001;82:2663–2674.
    1. Prince G.A., Curtis S.J., Yim K.C., Porter D.D. Vaccine-enhanced respiratory syncytial virus disease in cotton rats following immunization with Lot 100 or a newly prepared reference vaccine. J Gen Virol. 2001;82:2881–2888.
    1. Prince G.A., Jenson A.B., Hemming V.G., et al. Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactivated virus. J Virol. 1986;57:721–728.
    1. Sparer T.E., Matthews S., Hussell T., et al. Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia. J Exp Med. 1998;187:1921–1926. doi: 10.1084/jem.187.11.1921.
    1. Stevens W.W., Sun J., Castillo J.P., Braciale T.J. Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease. Viral Immunol. 2009;22:243–251. doi: 10.1089/vim.2009.0016.
    1. Englund J. In search of a vaccine for respiratory syncytial virus: the saga continues. J Infect Dis. 2005;191:1036–1039. doi: 10.1086/427998.
    1. Dudas R.A., Karron R.A. Respiratory syncytial virus vaccines. Clin Microbiol Rev. 1998;11:430–439.
    1. Durbin A.P., Karron R.A. Progress in the development of respiratory syncytial virus and parainfluenza virus vaccines. Clin Infect Dis. 2003;37:1668–1677. doi: 10.1086/379775.
    1. Kneyber M.C., Kimpen J.L. Advances in respiratory syncytial virus vaccine development. Curr Opin Investig Drugs. 2004;5:163–170.
    1. van Drunen Littel-van den Hurk S., Mapletoft J.W., Arsic N., Kovacs-Nolan J. Immunopathology of RSV infection: prospects for developing vaccines without this complication. Rev Med Virol. 2007;17:5–34. doi: 10.1002/rmv.518.
    1. Schickli J.H., Dubovsky F., Tang R.S. Challenges in developing a pediatric RSV vaccine. Hum Vaccin. 2009;5:582–591.
    1. Power U.F. Respiratory syncytial virus (RSV) vaccines—two steps back for one leap forward. J Clin Virol. 2008;41:38–44. doi: 10.1016/j.jcv.2007.10.024.
    1. Clyde W.A., Jr Experimental models for study of common respiratory viruses. Environ Health Perspect. 1980;35:107–112. doi: 10.1289/ehp.8035107.
    1. Coates H.V., Chanock R.M. Experimental infection with respiratory syncytial virus in several species of animals. Am J Hyg. 1962;76:302–312.
    1. Prince G.A., Porter D.D. The pathogenesis of respiratory syncytial virus infection in infant ferrets. Am J Pathol. 1976;82:339–352.
    1. Prince G.A., Horswood R.L., Chanock R.M. Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats. J Virol. 1985;55:517–520.
    1. Siber G.R., Leombruno D., Leszczynski J., et al. Comparison of antibody concentrations and protective activity of respiratory syncytial virus immune globulin and conventional immune globulin. J Infect Dis. 1994;169:1368–1373. doi: 10.1093/infdis/169.6.1368.

Source: PubMed

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