A double-blind, placebo-controlled, phase II, randomized study of lovastatin therapy in the treatment of mildly active rheumatoid arthritis
Cynthia Aranow, John Cush, Marcy B Bolster, Christopher C Striebich, Maria Dall'era, Meggan Mackay, Ewa Olech, Tracy Frech, Jane Box, Richard Keating, Mary Chester Wasko, William St Clair, Alan Kivitz, Weiquang Huang, PetaGay Ricketts, Beverly Welch, Sherrie Callahan, Meagan Spychala, Karen Boyle, Kate York, Lynette Keyes-Elstein, Ellen Goldmuntz, Betty Diamond, Anne Davidson, Cynthia Aranow, John Cush, Marcy B Bolster, Christopher C Striebich, Maria Dall'era, Meggan Mackay, Ewa Olech, Tracy Frech, Jane Box, Richard Keating, Mary Chester Wasko, William St Clair, Alan Kivitz, Weiquang Huang, PetaGay Ricketts, Beverly Welch, Sherrie Callahan, Meagan Spychala, Karen Boyle, Kate York, Lynette Keyes-Elstein, Ellen Goldmuntz, Betty Diamond, Anne Davidson
Abstract
Objectives: 3-hydroxy-3-methylglutaryl coenzyme-A (HMG Co-A) reductase inhibitors (statins) are standard treatment for hyperlipidaemia. In addition to lipid-lowering abilities, statins exhibit multiple anti-inflammatory effects. The objectives of this study were to determine whether treatment of patients with RA with lovastatin decreased CRP or reduced disease activity.
Methods: We conducted a randomized double-blind placebo-controlled 12 week trial of lovastatin vs placebo in 64 RA patients with mild clinical disease activity but an elevated CRP. The primary efficacy end point was the reduction in mean log CRP. Secondary end points included disease activity, RF and anti-CCP antibody titres. Mechanistic end points included levels of serum cytokines. Safety was assessed; hepatic and muscle toxicities were of particular interest.
Results: Baseline features were similar between groups. No significant difference in mean log CRP reduction between the two groups was observed, and disease activity did not change from baseline in either treatment group. Mechanistic analyses did not reveal significant changes in any biomarkers. A post hoc analysis of subjects not using biologic therapy demonstrated a significantly greater proportion achieving ⩾20% reduction in CRP from baseline in the lovastatin group compared with placebo (P-value = 0.007). No difference was observed in subjects receiving biologics. Lovastatin was well tolerated with no serious safety concerns.
Conclusion: This study showed no anti-inflammatory or clinical effects on RA disease activity after 12 weeks of treatment with lovastatin. Lovastatin had a modest effect on CRP in subjects not using biologics, suggesting statins may be anti-inflammatory in selected patients.
Trial registration: ClinicalTrials.gov, https://ichgcp.net/clinical-trials-registry/NCT00302952" title="See in ClinicalTrials.gov">NCT00302952.
Keywords: C-reactive protein; disease activity; inflammation; rheumatoid arthritis.
© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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Source: PubMed