Relating Experienced To Recalled breathlessness Observational (RETRO) study: a prospective study using a mobile phone application

Jacob Sandberg, Robert Lansing, Peter Anderberg, David Currow, Josefin Sundh, Zainab Ahmadi, Sebastian Palmqvist, Magnus Ekström, Jacob Sandberg, Robert Lansing, Peter Anderberg, David Currow, Josefin Sundh, Zainab Ahmadi, Sebastian Palmqvist, Magnus Ekström

Abstract

Background: Breathlessness, the subjective sensation of breathing discomfort, is common and appears in the daily life of people with cardiorespiratory diseases. Physicians often rely on patient's history based on symptom recall. The relation between recalled and experienced breathlessness is still poorly understood. This paper presents the protocol for a study primarily aimed at evaluating the relationship between experienced breathlessness and (1) recalled breathlessness and (2) predicted future breathlessness.

Methods: A mobile phone application will be used to collect data during daily life. Medically stable participants, ≥18 years of age with mean daily breathlessness of Numerical Rating Scale (NRS) 3/10 and able to use a mobile phone with internet will rate their breathlessness intensity on a 0-10 NRS prompted the user several times daily for 1 week. Participants will recall their breathlessness each day and week. Multivariable random effects regression models will be used for statistical analyses.

Results: Results of the study will be submitted for publication in peer-reviewed journals and presented at relevant conferences.

Discussion: This protocol describes a study aimed at investigating previously unknown areas of the experience and recall of breathlessness using a new method of data collection.

Registration details: Prospectively registered with ClinicalTrials.gov (Nr: NCT03468205).

Ethics and dissemination: The study has received ethical approval from the Regional Ethical Review Board Lund (DNr 2017/149). After a general study information including that participation is entirely voluntary, participants will answer the eligibility criteria and be asked to consent to participate before entering the study questions. Written informed consent to participate will be obtained for participants in the clinical sub-cohort. Participation can be discontinued at the discretion of the participant in which case no further data will be collected.

Keywords: app; breathlessness; cohort study; dyspnoea; mobile phone application; recall.

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Overview of the timing of planned assessments, starting with eligibility, consent and baseline assessments then continuing with several daily prompts asking on intensity of breathlessness as well as morning, evening and weekly assessments including daily recall and daily predictions as well as a weekly recall.

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