Effects of diacerein at the molecular level in the osteoarthritis disease process
Johanne Martel-Pelletier, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Jean-Pierre Pelletier
Abstract
In osteoarthritis (OA), the alterations in joint tissues are numerous and involve morphological, biochemical and metabolic changes and an upregulation of the inflammatory pathways. The focus of this article is a brief narrative review of the effects of diacerein, an antirheumatic drug from the anthraquinone chemical class, and its active metabolite, rhein, on the factors that participate in the complex interaction between OA tissues and cells leading to the progression of joint structural changes.
Keywords: cartilage; diacerein; osteoarthritis; rhein; subchondral bone; synovial membrane.
Conflict of interest statement
JMP and JPP have received grants from Laboratoires Negma-Lerads, Toussus-le-Noble, France and from TRB Chemedica International S.A., Geneva, Switzerland, as well as being speakers for these two companies at international and local congresses and meetings.
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Source: PubMed